Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | TsxAB/Xre(antitoxin) |
| Location | 7032..7533 | Replicon | plasmid pSCZE4 |
| Accession | NZ_CP051226 | ||
| Organism | Escherichia coli strain SCZE5 | ||
Toxin (Protein)
| Gene name | TsxA | Uniprot ID | H1ZXU8 |
| Locus tag | HF562_RS24530 | Protein ID | WP_000702247.1 |
| Coordinates | 7032..7292 (+) | Length | 87 a.a. |
Antitoxin (Protein)
| Gene name | TsxB | Uniprot ID | - |
| Locus tag | HF562_RS24535 | Protein ID | WP_001132407.1 |
| Coordinates | 7282..7533 (+) | Length | 84 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| HF562_RS24480 | 2083..2244 | + | 162 | WP_001128311.1 | hypothetical protein | - |
| HF562_RS24485 | 2628..2789 | + | 162 | WP_000775236.1 | type I toxin-antitoxin system Hok family toxin | - |
| HF562_RS24490 | 2939..3535 | + | 597 | WP_000125165.1 | hypothetical protein | - |
| HF562_RS24980 | 3553..3837 | - | 285 | WP_001162371.1 | hypothetical protein | - |
| HF562_RS24500 | 3911..4576 | - | 666 | WP_000532148.1 | P-loop NTPase | - |
| HF562_RS24505 | 5174..5503 | + | 330 | WP_000855120.1 | hypothetical protein | - |
| HF562_RS24510 | 5612..5758 | - | 147 | WP_001356709.1 | hypothetical protein | - |
| HF562_RS24515 | 6085..6408 | + | 324 | WP_000427403.1 | hypothetical protein | - |
| HF562_RS24520 | 6450..6659 | + | 210 | WP_000866036.1 | hypothetical protein | - |
| HF562_RS24525 | 6756..6980 | + | 225 | WP_000814381.1 | hypothetical protein | - |
| HF562_RS24530 | 7032..7292 | + | 261 | WP_000702247.1 | hypothetical protein | Toxin |
| HF562_RS24535 | 7282..7533 | + | 252 | WP_001132407.1 | transcriptional regulator | Antitoxin |
| HF562_RS24540 | 8083..8361 | + | 279 | WP_000545938.1 | hypothetical protein | - |
| HF562_RS24545 | 8781..9047 | + | 267 | WP_000681608.1 | type II toxin-antitoxin system HicB family antitoxin | - |
| HF562_RS24550 | 9154..9336 | - | 183 | WP_001481829.1 | hypothetical protein | - |
| HF562_RS24555 | 9894..10076 | + | 183 | WP_000833470.1 | type II toxin-antitoxin system HicA family toxin | - |
| HF562_RS24560 | 10101..10538 | + | 438 | WP_000466318.1 | type II toxin-antitoxin system HicB family antitoxin | - |
| HF562_RS24565 | 10669..10995 | - | 327 | WP_063078684.1 | hypothetical protein | - |
| HF562_RS24570 | 11015..11722 | - | 708 | WP_021503228.1 | hypothetical protein | - |
| HF562_RS24575 | 11724..12476 | - | 753 | WP_063078685.1 | conjugal transfer protein TraL | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Mobilizable plasmid | mcr-1.1 | - | 1..60732 | 60732 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 87 a.a. Molecular weight: 9817.29 Da Isoelectric Point: 10.0665
>T153913 WP_000702247.1 NZ_CP051226:7032-7292 [Escherichia coli]
MKIRKGDRQYYLNKEGDTFHLVKRVKTFSKSATLGKTKATVKTVADLVFHEKAFDTIDFASDGLRENDKEIVSMMIQEMS
EGKNAK
MKIRKGDRQYYLNKEGDTFHLVKRVKTFSKSATLGKTKATVKTVADLVFHEKAFDTIDFASDGLRENDKEIVSMMIQEMS
EGKNAK
Download Length: 261 bp
>T153913 NZ_CP067245:c2016573-2016175 [Escherichia coli]
ATGCGGGTATTCAAAACAAAACTTATTCGCCTGCAACTTACAGCAGAGGAACTTGATGCGTTAACGGCGGATTTTATTTC
CTATAAGCGTGACGGTGTTTTGCCAGATATATTTGGTCGCGATGCACTCTACGACGACTCGTTTACCTGGCCATTAATCA
AATTTGAGCGAGTTGCTCATATTCATCTGGCAAATGTGAATAATCCATTTCCGCCACAGTTGCGCCAATTCAGCAGAACG
AATGACGAAGCGCATTTGGTATATTGTCAGGGTGCGTTTGATGAGCAAGCATGGTTGCTCATTGCCATTCTGAAACCTGA
ACCTCATAAACAGGCTCGAGATAACAACCAAATGCATAAAATTGGGAAAATGGCAGAAGCGTTTCGCATGCGTTTTTGA
ATGCGGGTATTCAAAACAAAACTTATTCGCCTGCAACTTACAGCAGAGGAACTTGATGCGTTAACGGCGGATTTTATTTC
CTATAAGCGTGACGGTGTTTTGCCAGATATATTTGGTCGCGATGCACTCTACGACGACTCGTTTACCTGGCCATTAATCA
AATTTGAGCGAGTTGCTCATATTCATCTGGCAAATGTGAATAATCCATTTCCGCCACAGTTGCGCCAATTCAGCAGAACG
AATGACGAAGCGCATTTGGTATATTGTCAGGGTGCGTTTGATGAGCAAGCATGGTTGCTCATTGCCATTCTGAAACCTGA
ACCTCATAAACAGGCTCGAGATAACAACCAAATGCATAAAATTGGGAAAATGGCAGAAGCGTTTCGCATGCGTTTTTGA
Antitoxin
Download Length: 84 a.a. Molecular weight: 9404.77 Da Isoelectric Point: 9.8120
>AT153913 WP_001132407.1 NZ_CP051226:7282-7533 [Escherichia coli]
MPNENTPENIKRLRQKIGLTQKECAEIFSMSPRTWRRKEEPVGTASGTALTPVEFKFLLLLAGEHPDYVLCKRNKKNSDS
GSN
MPNENTPENIKRLRQKIGLTQKECAEIFSMSPRTWRRKEEPVGTASGTALTPVEFKFLLLLAGEHPDYVLCKRNKKNSDS
GSN
Download Length: 252 bp
>AT153913 NZ_CP067245:c2016869-2016576 [Escherichia coli]
ATGCATCGAATTCTCGCTGAAAAATCGGTCAATATTACTGAGTTACGTAAAAACCCAGCTAAATACTTTATTGATCAACC
GGTTGCGGTTCTTTCTAATAATCGCCCCGCAGGATATCTCTTAAGTGCCAGCGCATTCGAAGCGTTAATGGACATGCTTG
CTGAACAAGAGGAGAAAAAGCCCATAAAGGCGCGCTTCCGTCCAAGTGCTGCAAGATTAGAGGAAATTACACGCCGAGCT
GAAAAATATCTTAATGATATGACGGATGATGATTTCAATGACTTTAAGGAATAA
ATGCATCGAATTCTCGCTGAAAAATCGGTCAATATTACTGAGTTACGTAAAAACCCAGCTAAATACTTTATTGATCAACC
GGTTGCGGTTCTTTCTAATAATCGCCCCGCAGGATATCTCTTAAGTGCCAGCGCATTCGAAGCGTTAATGGACATGCTTG
CTGAACAAGAGGAGAAAAAGCCCATAAAGGCGCGCTTCCGTCCAAGTGCTGCAAGATTAGAGGAAATTACACGCCGAGCT
GAAAAATATCTTAATGATATGACGGATGATGATTTCAATGACTTTAAGGAATAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|