Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 2913666..2914510 Replicon chromosome
Accession NZ_CP051222
Organism Escherichia coli strain SCZE5

Toxin (Protein)


Gene name yeeV Uniprot ID B1LJY4
Locus tag HF562_RS14325 Protein ID WP_000854686.1
Coordinates 2913666..2914049 (-) Length 128 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A8E0J1S3
Locus tag HF562_RS14330 Protein ID WP_001285602.1
Coordinates 2914130..2914510 (-) Length 127 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HF562_RS14285 2908669..2909160 - 492 WP_001300785.1 DUF1097 domain-containing protein -
HF562_RS14290 2909262..2909816 - 555 WP_001001902.1 molecular chaperone YcdY -
HF562_RS14295 2909840..2910576 - 737 Protein_2803 zinc-binding phosphatase -
HF562_RS14300 2910631..2911569 - 939 WP_000351315.1 glyoxylate/hydroxypyruvate reductase GhrA -
HF562_RS14310 2912041..2912882 - 842 Protein_2805 DUF4942 domain-containing protein -
HF562_RS14315 2912967..2913164 - 198 WP_000839253.1 DUF957 domain-containing protein -
HF562_RS14320 2913181..2913669 - 489 WP_032180032.1 hypothetical protein -
HF562_RS14325 2913666..2914049 - 384 WP_000854686.1 TA system toxin CbtA family protein Toxin
HF562_RS14330 2914130..2914510 - 381 WP_001285602.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
HF562_RS14335 2914521..2915204 - 684 WP_000086768.1 hypothetical protein -
HF562_RS14340 2915223..2915444 - 222 WP_000692298.1 DUF987 domain-containing protein -
HF562_RS14345 2915507..2915983 - 477 WP_001186726.1 RadC family protein -
HF562_RS14350 2915999..2916484 - 486 WP_000214307.1 antirestriction protein -
HF562_RS14355 2916576..2916911 - 336 Protein_2814 DUF932 domain-containing protein -
HF562_RS14360 2916907..2918031 - 1125 Protein_2815 AIDA repeat-containing protein -
HF562_RS14365 2918403..2919275 - 873 WP_001069760.1 GTPase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - csgB / csgD / csgE / csgF / csgG 2905050..2951641 46591


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-113)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 128 a.a.        Molecular weight: 14272.28 Da        Isoelectric Point: 6.8614

>T153897 WP_000854686.1 NZ_CP051222:c2914049-2913666 [Escherichia coli]
MKTLPDTHVRAASRCPSPVEIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYVLVRTDQPGF
SAGAPSSQLINSIDILRARRATGLMTRDNYRMVNNITLGKHPEEAKQ

Download         Length: 384 bp

>T153897 NZ_CP067241:3740815-3741357 [Escherichia coli]
ATGGTCGACAAGCATGAAGAGATTACTCTGCCCATAGTCCTCTCCTGTAATTATCAGTCTGATATTATTTATCCTGGGCA
AAAACAGTTTGATTGCGGTAACCCTGTTATCGATAAATTTGTACGCGCATCGCTAAAGAAAAGTGTGCGTAATAGCGACT
GTGCTGCTAAAGCTCTTATTGACAGACAAAGTGGTGAACTGATTGGCATCTGTACTTTTACGGCATATTCGCTGGAAAAA
CAACGCGTTTCTGGCGTCCTTCAGGGTTCACAACCTTCAGAGATTGGTGTTGTCAGATTAGTCATGTTAGGGGTAGCGCG
GAAATATCAAAAGCGGGGCTTTGGTCAGGACCTACTATGTAATTTTTTTGAACATGTAAAAATAATTCACCGGGCATTAC
CAATTAAAGGGGTTTATCTTGATGCTGACCCTGCCGCCATTAACTTTTATACTCGCCTCGGCTTTGTTCAGCTTTCAGCG
AGGCCCAATGTTTTCGGTGCTGTACCGATGTTTTTAGCGATTCAGCATATTCTCGCGGCTTAG

Antitoxin


Download         Length: 127 a.a.        Molecular weight: 13938.69 Da        Isoelectric Point: 5.0823

>AT153897 WP_001285602.1 NZ_CP051222:c2914510-2914130 [Escherichia coli]
VSDTLPGTTLPDDNKDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFSNADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCDADTLGSCGYVYLAVYPATETESNPPE

Download         Length: 381 bp

>AT153897 NZ_CP067241:3740520-3740831 [Escherichia coli]
ATGCCTGGAAAAACAGTCGCTCTACCCGATATCGATAAAACGCTGAAAAATGCGCGGGTTGAACTCAAAACCAGTCCCGA
CGCCAAAAACAAACTTCGTGAAGCTGCGCAAGCCGTTGGGGTAGATTTAAGCGCTTTTATTTTGAGCGCAGCTATGGAAC
GCGCCGAAAGTGTGCTTGATAACCAACGTCGCCGTGAGCTTTCGAATCAAAGCTGGGAACTGATGAACCAACTCATCGCT
GAACCTGCTCAACCGACGCTCGCCCTCAAGGCGTTAATGAAAAGGAAAAACAGCGATGGTCGACAAGCATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References