Detailed information of TA system TA153883

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): yeeUV (cbtA-cbeA)/CbtA-CbeA
• Location: 898024..898859
• Replicon: chromosome
• Accession: NZ_CP051222
• Organism: Escherichia coli strain SCZE5

Toxin (Protein)

• Gene name: yeeV
• Uniprot ID: -
• Locus tag: HF562_RS04300
• Protein ID: WP_057109034.1
• Coordinates: 898024..898401 (-)
• Length: 126 a.a.

Antitoxin (Protein)

• Gene name: yeeU
• Uniprot ID: B7MK11
• Locus tag: HF562_RS04305
• Protein ID: WP_001285610.1
• Coordinates: 898491..898859 (-)
• Length: 123 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HF562_RS04270	894029..894525	+	497	Protein_840	type VI secretion system contractile sheath small subunit	-
HF562_RS04275	895059..895352	+	294	WP_001110459.1	DUF1778 domain-containing protein	-
HF562_RS04280	895349..895837	+	489	WP_000622309.1	GNAT family N-acetyltransferase	-
HF562_RS04285	896678..897520	-	843	WP_039004748.1	DUF4942 domain-containing protein	-
HF562_RS04290	897605..897802	-	198	WP_023563519.1	DUF957 domain-containing protein	-
HF562_RS04295	897878..898027	-	150	Protein_845	hypothetical protein	-
HF562_RS04300	898024..898401	-	378	WP_057109034.1	TA system toxin CbtA family protein	Toxin
HF562_RS04305	898491..898859	-	369	WP_001285610.1	type IV toxin-antitoxin system YeeU family antitoxin	Antitoxin
HF562_RS24860	898933..899154	-	222	Protein_848	DUF987 domain-containing protein	-
HF562_RS04320	899241..899717	-	477	WP_057109035.1	RadC family protein	-
HF562_RS04325	899733..900212	-	480	WP_057109036.1	antirestriction protein	-
HF562_RS04330	900312..900452	+	141	WP_000997937.1	hypothetical protein	-
HF562_RS04335	900478..901296	-	819	WP_001175153.1	DUF945 domain-containing protein	-
HF562_RS04340	901386..901619	-	234	WP_001278287.1	DUF905 family protein	-
HF562_RS04345	901625..902302	-	678	WP_001097368.1	hypothetical protein	-
HF562_RS04350	902421..903305	-	885	WP_000010392.1	50S ribosome-binding GTPase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• CbtA toxin of type IV toxin-antitoxin system (1-112)

Antitoxin

• Antitoxin CbeA (19-117)

Sequences

Toxin

Protein

• Length: 126 a.a.
• Molecular weight: 13934.86 Da
• Isoelectric Point: 6.8517

>T153883 WP_057109034.1 NZ_CP051222:c898401-898024 [Escherichia coli]
MKTLPDTHVREASCCPSPVTIWQTLLTRLLDQHYGLALNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SAGASSQLINSIDILRARRATGLMTRDNYRTVNNITLGKHPEAKQ

Nucleotide

• Length: 378 bp

>T153883 NZ_CP067241:790375-790671 [Escherichia coli]
ATGGAAAAACGCACACCACATACACGTTTGAGTCAGGTTAAAAAACTTGTCAATGCCGGGCAAGTTCGTACAACACGTAG
TGCCCTGTTAAATGCAGATGAGTTAGGTTTGGATTTTGATGGTATGTGTAATGTTATCATTGGATTATCAGAGAGCGACT
TTTATAAAAGCATGACCACCTACTCTGATCATACTATCTGGCAGGATGTTTACAGACCCAGGCTTGTTACAGGCCAGGTT
TATCTTAAAATTACGGTAATTCATGACGTACTGATCGTCTCGTTTAAGGAGAAGTAA

Antitoxin

Protein

• Length: 123 a.a.
• Molecular weight: 13606.39 Da
• Isoelectric Point: 6.0618

>AT153883 WP_001285610.1 NZ_CP051222:c898859-898491 [Escherichia coli]
VSDTLPGTTLPDDNNDRTWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFSDADSYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCEADTLGSCGYVYMAVYPTPETKK

Nucleotide

• Length: 369 bp

>AT153883 NZ_CP067241:790673-791068 [Escherichia coli]
ATGAAATGTCCGGTTTGCCACCAGGGAGAAATGGTTTCTGGCATTAAAGATATTCCATACACCTTCCGTGGACGAAAAAC
AGTATTGAAAGGTATCCACGGTTTATATTGTGTCCATTGCGAAGAGAGCATCATGAATAAAGAAGAGTCAGATGCTTTCA
TGGCGCAAGTAAAGGCATTTCGGGCTTCGGTGAATGCCGAAACAGTGGCACCTGAATTTATAGTGAAGGTTCGAAAAAAG
CTCTCTCTTACCCAAAAAGAGGCAAGCGAAATTTTTGGGGGAGGTGTAAATGCGTTTTCGCGTTACGAAAAAGGCAATGC
CCAACCTCATCCTTCCACAATCAAACTTTTACGTGTTCTGGATAAGCATCCAGAACTATTGAATGAAATCCGTTAA