Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 763931..764766 Replicon chromosome
Accession NZ_CP051222
Organism Escherichia coli strain SCZE5

Toxin (Protein)


Gene name yeeV Uniprot ID A0A1V3VXN0
Locus tag HF562_RS03675 Protein ID WP_000854801.1
Coordinates 764389..764766 (+) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A1V3VXQ4
Locus tag HF562_RS03670 Protein ID WP_001360188.1
Coordinates 763931..764299 (+) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HF562_RS03645 761046..761864 + 819 WP_001234702.1 DUF945 domain-containing protein -
HF562_RS03650 761955..762440 + 486 WP_000214418.1 antirestriction protein -
HF562_RS03655 762456..762932 + 477 WP_001186725.1 RadC family protein -
HF562_RS03660 763001..763222 + 222 WP_000692334.1 DUF987 domain-containing protein -
HF562_RS03665 763237..763881 + 645 WP_000086744.1 hypothetical protein -
HF562_RS03670 763931..764299 + 369 WP_001360188.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
HF562_RS03675 764389..764766 + 378 WP_000854801.1 type IV toxin-antitoxin system toxin CbtA Toxin
HF562_RS03680 764763..765251 + 489 WP_000761658.1 hypothetical protein -
HF562_RS03685 765263..765460 + 198 WP_000839269.1 DUF957 domain-containing protein -
HF562_RS03690 765545..766390 + 846 Protein_725 DUF4942 domain-containing protein -
HF562_RS03700 766690..767196 + 507 WP_000228937.1 G/U mismatch-specific DNA glycosylase -
HF562_RS03705 767275..769116 - 1842 WP_000437375.1 RNA polymerase sigma factor RpoD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 13881.87 Da        Isoelectric Point: 7.3219

>T153881 WP_000854801.1 NZ_CP051222:764389-764766 [Escherichia coli]
MKTLPVLPGQAASSRPSPVEIWQILLSQLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTHSQLINSIDILRARRATGLMTRDNYRTVNNITLGKHPGAKQ

Download         Length: 378 bp

>T153881 NZ_CP067241:351105-351380 [Escherichia coli]
ATGAGAACCCAGGTACAGGCTTTACGGAAGAAACAAAAAAATACATTGGATCAAATATTTAAATCTCCTGTTCCTCAAGG
GATTAAGTGGTCTGATATAGAGTCACTGGTTAAAGCATTAGGCGGAGAAATTAAGGAAGGAAGAGGTTCGCGTTGTAAGT
TCATACTAAATATGAGCGTTGCGTGTTTCCATCGGCCTCATCCGTCGCCAGATACCGATAAAGGCGCTGTAGAAAGCGTG
CGTGACTGGTTACTAAGTATAGGGGTAAAACCATGA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13563.27 Da        Isoelectric Point: 6.2044

>AT153881 WP_001360188.1 NZ_CP051222:763931-764299 [Escherichia coli]
VSDTLSGTTHPDDNHDRPWWGLPCTVTPCFGARLVQEGNQLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGVTCEADTLGSCGYVYLAVYPTPETKK

Download         Length: 369 bp

>AT153881 NZ_CP067241:351377-351736 [Escherichia coli]
ATGATCAAACTGAAGACGCCAAACTCTATGGAGATTGCCGGGCAACCTGCTGTTATCACTTACGTGCCAGAACTGAATGC
ATTTCGTGGCAAATTCCTGGGCTTGTCAGGTTATTGTGATTTTGTCTCTGACAGCATTCAGGGGCTGCAAAAAGAAGGGG
AGCTTTCCCTGCGAGAGTATCTTGAGGATTGTAAAGCTGCGGGTATTGAGCCGTATGCGCGTACAGAAAAGATTAAGACC
TTTACATTACGCTATCCAGAATCGCTGAGTGAACGCCTTAATAATGCGGCTGCGCAGCAACAAGTCTCTGTAAATACTTA
TATTATTGAAACGCTAAATGAGCGTTTGAATCATTTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1V3VXN0

Antitoxin

Source ID Structure
AlphaFold DB A0A1V3VXQ4

References