Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 4549815..4550650 Replicon chromosome
Accession NZ_CP051219
Organism Escherichia coli strain SFE8

Toxin (Protein)


Gene name yeeV Uniprot ID A0A2Y8M938
Locus tag HF527_RS22145 Protein ID WP_047661875.1
Coordinates 4550273..4550650 (+) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A2Y0C7M1
Locus tag HF527_RS22140 Protein ID WP_047661876.1
Coordinates 4549815..4550183 (+) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HF527_RS22100 4544921..4545805 + 885 WP_032216515.1 50S ribosome-binding GTPase -
HF527_RS22105 4545924..4546601 + 678 WP_021546486.1 hypothetical protein -
HF527_RS22110 4546607..4546840 + 234 WP_001278287.1 DUF905 family protein -
HF527_RS22115 4546930..4547748 + 819 WP_094284462.1 DUF945 domain-containing protein -
HF527_RS22120 4547839..4548324 + 486 WP_073527669.1 antirestriction protein -
HF527_RS22125 4548340..4548816 + 477 WP_041124171.1 RadC family protein -
HF527_RS22130 4548885..4549106 + 222 WP_047661878.1 DUF987 domain-containing protein -
HF527_RS22135 4549121..4549765 + 645 WP_047661877.1 hypothetical protein -
HF527_RS22140 4549815..4550183 + 369 WP_047661876.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
HF527_RS22145 4550273..4550650 + 378 WP_047661875.1 TA system toxin CbtA family protein Toxin
HF527_RS22150 4550647..4550844 + 198 Protein_4335 hypothetical protein -
HF527_RS22155 4550872..4551069 + 198 WP_087891818.1 DUF957 domain-containing protein -
HF527_RS22160 4551154..4552020 + 867 WP_047661874.1 DUF4942 domain-containing protein -
HF527_RS22165 4552092..4552355 + 264 WP_001143297.1 type II toxin-antitoxin system ParD family antitoxin -
HF527_RS22170 4552352..4552678 + 327 WP_000779483.1 type II toxin-antitoxin system RelE/ParE family toxin -
HF527_RS22175 4553561..4555099 + 1539 WP_001187170.1 lysine decarboxylation/transport transcriptional activator CadC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 14195.18 Da        Isoelectric Point: 8.8867

>T153869 WP_047661875.1 NZ_CP051219:4550273-4550650 [Escherichia coli]
MKTSPDTHVREASCCPSPVTIWQTLLSRLLDQHYGLTLNNTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
STCPRSQFINSIDILRARRATGLMTRSHYRTVNNITRGKHPEAKR

Download         Length: 378 bp

>T153869 NZ_CP067235:c4475001-4474459 [Escherichia coli]
ATGGTCGACAAGCATGAAGAGATTACTCTGCCCATAGTCCTCTCCTGTAATTATCAGTCTGATATTACTTATCCTGGGCA
AAAACAGTTTGATTGCGGTAACCCTGTTATCGATAAATTTGTACGCGCATCGCTAAAGAAAAGTGTGCGTAATAGCGACT
GTGCTGCTAAAGCTCTTATTGACAGACAAAGTGGTGAACTGATTGGCATCTGTACTTTTACGGCATATTCGCTGGAAAAA
CAACGCGTTTCTGGCGTCCTTCAGGGTTCACAACCTTCAGAGATTGGTGTTGTCAGATTAGTCATGTTAGGGGTAGCGCG
GAAATATCAAAAGCGGGGCTTTGGTCAGGACCTACTATGTGATTTTTTTGAACATGTAAAAATAATTCACCGGGCATTAC
CAATTAAAGGGGTTTATCTTGATGCTGACCCTGCCGCCATTAACTTTTATACTCGCCTCGGCTTTGTTCAGCTTTCAGCG
AGGCCCAATGTTTTCGGTGCTGTACCGATGTTTTTAGCGATTCAGCATATTCTCGCGGCTTAG

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13660.30 Da        Isoelectric Point: 5.4561

>AT153869 WP_047661876.1 NZ_CP051219:4549815-4550183 [Escherichia coli]
VSDSLHETNYPDDHNDRPWWGLPCTVTPCFGARLVQEGNQLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELSPRHQHTVTLYAKGLTCEADTLGSCGYVYLAVYPTSETKT

Download         Length: 369 bp

>AT153869 NZ_CP067235:c4475296-4474985 [Escherichia coli]
ATGCCTGGAAAAACAGTCGCTCTACCCGATATCGATAAAACGCTGAAAAATGCGCGGGTTGAACTCAAAACCAGCCCCGA
CGCCAAAAACAAACTTCGTGAAGCTGCGCAAGCCGTTGGGGTAGATTTAAGCGCTTTTATTTTGAGCGCAGCTATGGAAC
GCGCCGAAAGTGTGCTTGATAACCAACGTCGCCGTGAGCTTTCGAATCAAAGCTGGGAACTGATGAACCAACTCATCGCT
GAACCTGCTCAACCGACGCTCGCCCTCAAGGCGTTAATGAAAAGGAAAAACAGCGATGGTCGACAAGCATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2Y8M938

Antitoxin

Source ID Structure
AlphaFold DB A0A2Y0C7M1

References