Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | IV | Classification (family/domain) | yeeUV (cbtA-cbeA)/CbtA-CbeA |
Location | 4549815..4550650 | Replicon | chromosome |
Accession | NZ_CP051219 | ||
Organism | Escherichia coli strain SFE8 |
Toxin (Protein)
Gene name | yeeV | Uniprot ID | A0A2Y8M938 |
Locus tag | HF527_RS22145 | Protein ID | WP_047661875.1 |
Coordinates | 4550273..4550650 (+) | Length | 126 a.a. |
Antitoxin (Protein)
Gene name | yeeU | Uniprot ID | A0A2Y0C7M1 |
Locus tag | HF527_RS22140 | Protein ID | WP_047661876.1 |
Coordinates | 4549815..4550183 (+) | Length | 123 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
HF527_RS22100 | 4544921..4545805 | + | 885 | WP_032216515.1 | 50S ribosome-binding GTPase | - |
HF527_RS22105 | 4545924..4546601 | + | 678 | WP_021546486.1 | hypothetical protein | - |
HF527_RS22110 | 4546607..4546840 | + | 234 | WP_001278287.1 | DUF905 family protein | - |
HF527_RS22115 | 4546930..4547748 | + | 819 | WP_094284462.1 | DUF945 domain-containing protein | - |
HF527_RS22120 | 4547839..4548324 | + | 486 | WP_073527669.1 | antirestriction protein | - |
HF527_RS22125 | 4548340..4548816 | + | 477 | WP_041124171.1 | RadC family protein | - |
HF527_RS22130 | 4548885..4549106 | + | 222 | WP_047661878.1 | DUF987 domain-containing protein | - |
HF527_RS22135 | 4549121..4549765 | + | 645 | WP_047661877.1 | hypothetical protein | - |
HF527_RS22140 | 4549815..4550183 | + | 369 | WP_047661876.1 | type IV toxin-antitoxin system YeeU family antitoxin | Antitoxin |
HF527_RS22145 | 4550273..4550650 | + | 378 | WP_047661875.1 | TA system toxin CbtA family protein | Toxin |
HF527_RS22150 | 4550647..4550844 | + | 198 | Protein_4335 | hypothetical protein | - |
HF527_RS22155 | 4550872..4551069 | + | 198 | WP_087891818.1 | DUF957 domain-containing protein | - |
HF527_RS22160 | 4551154..4552020 | + | 867 | WP_047661874.1 | DUF4942 domain-containing protein | - |
HF527_RS22165 | 4552092..4552355 | + | 264 | WP_001143297.1 | type II toxin-antitoxin system ParD family antitoxin | - |
HF527_RS22170 | 4552352..4552678 | + | 327 | WP_000779483.1 | type II toxin-antitoxin system RelE/ParE family toxin | - |
HF527_RS22175 | 4553561..4555099 | + | 1539 | WP_001187170.1 | lysine decarboxylation/transport transcriptional activator CadC | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 126 a.a. Molecular weight: 14195.18 Da Isoelectric Point: 8.8867
>T153869 WP_047661875.1 NZ_CP051219:4550273-4550650 [Escherichia coli]
MKTSPDTHVREASCCPSPVTIWQTLLSRLLDQHYGLTLNNTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
STCPRSQFINSIDILRARRATGLMTRSHYRTVNNITRGKHPEAKR
MKTSPDTHVREASCCPSPVTIWQTLLSRLLDQHYGLTLNNTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
STCPRSQFINSIDILRARRATGLMTRSHYRTVNNITRGKHPEAKR
Download Length: 378 bp
>T153869 NZ_CP067235:c4475001-4474459 [Escherichia coli]
ATGGTCGACAAGCATGAAGAGATTACTCTGCCCATAGTCCTCTCCTGTAATTATCAGTCTGATATTACTTATCCTGGGCA
AAAACAGTTTGATTGCGGTAACCCTGTTATCGATAAATTTGTACGCGCATCGCTAAAGAAAAGTGTGCGTAATAGCGACT
GTGCTGCTAAAGCTCTTATTGACAGACAAAGTGGTGAACTGATTGGCATCTGTACTTTTACGGCATATTCGCTGGAAAAA
CAACGCGTTTCTGGCGTCCTTCAGGGTTCACAACCTTCAGAGATTGGTGTTGTCAGATTAGTCATGTTAGGGGTAGCGCG
GAAATATCAAAAGCGGGGCTTTGGTCAGGACCTACTATGTGATTTTTTTGAACATGTAAAAATAATTCACCGGGCATTAC
CAATTAAAGGGGTTTATCTTGATGCTGACCCTGCCGCCATTAACTTTTATACTCGCCTCGGCTTTGTTCAGCTTTCAGCG
AGGCCCAATGTTTTCGGTGCTGTACCGATGTTTTTAGCGATTCAGCATATTCTCGCGGCTTAG
ATGGTCGACAAGCATGAAGAGATTACTCTGCCCATAGTCCTCTCCTGTAATTATCAGTCTGATATTACTTATCCTGGGCA
AAAACAGTTTGATTGCGGTAACCCTGTTATCGATAAATTTGTACGCGCATCGCTAAAGAAAAGTGTGCGTAATAGCGACT
GTGCTGCTAAAGCTCTTATTGACAGACAAAGTGGTGAACTGATTGGCATCTGTACTTTTACGGCATATTCGCTGGAAAAA
CAACGCGTTTCTGGCGTCCTTCAGGGTTCACAACCTTCAGAGATTGGTGTTGTCAGATTAGTCATGTTAGGGGTAGCGCG
GAAATATCAAAAGCGGGGCTTTGGTCAGGACCTACTATGTGATTTTTTTGAACATGTAAAAATAATTCACCGGGCATTAC
CAATTAAAGGGGTTTATCTTGATGCTGACCCTGCCGCCATTAACTTTTATACTCGCCTCGGCTTTGTTCAGCTTTCAGCG
AGGCCCAATGTTTTCGGTGCTGTACCGATGTTTTTAGCGATTCAGCATATTCTCGCGGCTTAG
Antitoxin
Download Length: 123 a.a. Molecular weight: 13660.30 Da Isoelectric Point: 5.4561
>AT153869 WP_047661876.1 NZ_CP051219:4549815-4550183 [Escherichia coli]
VSDSLHETNYPDDHNDRPWWGLPCTVTPCFGARLVQEGNQLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELSPRHQHTVTLYAKGLTCEADTLGSCGYVYLAVYPTSETKT
VSDSLHETNYPDDHNDRPWWGLPCTVTPCFGARLVQEGNQLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELSPRHQHTVTLYAKGLTCEADTLGSCGYVYLAVYPTSETKT
Download Length: 369 bp
>AT153869 NZ_CP067235:c4475296-4474985 [Escherichia coli]
ATGCCTGGAAAAACAGTCGCTCTACCCGATATCGATAAAACGCTGAAAAATGCGCGGGTTGAACTCAAAACCAGCCCCGA
CGCCAAAAACAAACTTCGTGAAGCTGCGCAAGCCGTTGGGGTAGATTTAAGCGCTTTTATTTTGAGCGCAGCTATGGAAC
GCGCCGAAAGTGTGCTTGATAACCAACGTCGCCGTGAGCTTTCGAATCAAAGCTGGGAACTGATGAACCAACTCATCGCT
GAACCTGCTCAACCGACGCTCGCCCTCAAGGCGTTAATGAAAAGGAAAAACAGCGATGGTCGACAAGCATGA
ATGCCTGGAAAAACAGTCGCTCTACCCGATATCGATAAAACGCTGAAAAATGCGCGGGTTGAACTCAAAACCAGCCCCGA
CGCCAAAAACAAACTTCGTGAAGCTGCGCAAGCCGTTGGGGTAGATTTAAGCGCTTTTATTTTGAGCGCAGCTATGGAAC
GCGCCGAAAGTGTGCTTGATAACCAACGTCGCCGTGAGCTTTCGAATCAAAGCTGGGAACTGATGAACCAACTCATCGCT
GAACCTGCTCAACCGACGCTCGCCCTCAAGGCGTTAATGAAAAGGAAAAACAGCGATGGTCGACAAGCATGA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A2Y8M938 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A2Y0C7M1 |