Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3700015..3700633 Replicon chromosome
Accession NZ_CP051219
Organism Escherichia coli strain SFE8

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag HF527_RS18030 Protein ID WP_001291435.1
Coordinates 3700415..3700633 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag HF527_RS18025 Protein ID WP_000344800.1
Coordinates 3700015..3700389 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HF527_RS18015 3695104..3696297 + 1194 WP_001295324.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
HF527_RS18020 3696320..3699469 + 3150 WP_001132469.1 multidrug efflux RND transporter permease subunit -
HF527_RS18025 3700015..3700389 + 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
HF527_RS18030 3700415..3700633 + 219 WP_001291435.1 hemolysin expression modulator Hha Toxin
HF527_RS18035 3700804..3701355 + 552 WP_000102556.1 maltose O-acetyltransferase -
HF527_RS18040 3701471..3701941 + 471 WP_000136192.1 YlaC family protein -
HF527_RS18045 3702105..3703655 + 1551 WP_001299455.1 cyclic-guanylate-specific phosphodiesterase PdeB -
HF527_RS18050 3703697..3704050 - 354 WP_000878140.1 DUF1428 domain-containing protein -
HF527_RS18060 3704429..3704740 + 312 WP_000409911.1 MGMT family protein -
HF527_RS18065 3704771..3705343 - 573 WP_000779831.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T153865 WP_001291435.1 NZ_CP051219:3700415-3700633 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

>T153865 NZ_CP067235:c2875642-2875535 [Escherichia coli]
ATGACGCTCGCAGAGCTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGCATGAT
CGTGAACTGGCTGAACAAGCGGAAGTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT153865 WP_000344800.1 NZ_CP051219:3700015-3700389 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp

>AT153865 NZ_CP067235:2875690-2875756 [Escherichia coli]
GGTCTAGAGTCAAGATTAGCCCCCGTGGTGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References