153864

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/UPF0150(antitoxin)
Location 2678280..2678918 Replicon chromosome
Accession NZ_CP051219
Organism Escherichia coli strain SFE8

Toxin (Protein)


Gene name hicA Uniprot ID S1F9G9
Locus tag HF527_RS13035 Protein ID WP_000813794.1
Coordinates 2678742..2678918 (-) Length 59 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag HF527_RS13030 Protein ID WP_001270286.1
Coordinates 2678280..2678696 (-) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HF527_RS13010 2673432..2674373 - 942 WP_001251313.1 ABC transporter permease -
HF527_RS13015 2674374..2675387 - 1014 WP_001542893.1 ABC transporter ATP-binding protein -
HF527_RS13020 2675405..2676550 - 1146 WP_000047424.1 ABC transporter substrate-binding protein -
HF527_RS13025 2676795..2678201 - 1407 WP_000760663.1 PLP-dependent aminotransferase family protein -
HF527_RS13030 2678280..2678696 - 417 WP_001270286.1 type II toxin-antitoxin system antitoxin HicB Antitoxin
HF527_RS13035 2678742..2678918 - 177 WP_000813794.1 type II toxin-antitoxin system mRNA interferase toxin HicA Toxin
HF527_RS13040 2679140..2679370 + 231 WP_000494244.1 YncJ family protein -
HF527_RS13045 2679462..2681423 - 1962 WP_001442195.1 23S rRNA 5-hydroxycytidine C2501 synthase -
HF527_RS13050 2681496..2682032 - 537 WP_000429155.1 DNA-binding transcriptional regulator SutR -
HF527_RS13055 2682085..2683299 + 1215 WP_071609973.1 BenE family transporter YdcO -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 2683339..2684487 1148


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-57)

Antitoxin

Cro/C1-type helix-turn-helix domain

(91-134)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6749.83 Da        Isoelectric Point: 11.2298

>T153864 WP_000813794.1 NZ_CP051219:c2678918-2678742 [Escherichia coli]
VKQSEFRRWLESQGVDVANGSNHLKLRFHGRRSVMPRHPCDEIKEPLRKAILKQLGLS

Download         Length: 177 bp

>T153864 NZ_CP067235:c2875158-2875051 [Escherichia coli]
ATGACGCTCGCAGAGCTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTCTGAT
CGTGAACTGGCTGAACAAGCGGAAGTAA

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15246.63 Da        Isoelectric Point: 4.7386

>AT153864 WP_001270286.1 NZ_CP051219:c2678696-2678280 [Escherichia coli]
MRYPVTLTPAPEGGYMVSFVDIPEALTQGETVAEAMEAAKDALLTAFDFYFEDNELIPLPSPLNSHDHFIEVPLSVASKV
LLLNAFLQSEITQQELARRIGKPKQEITRLFNLHHATKIDAVQLAAKALGKELSLVMV

Download         Length: 417 bp

>AT153864 NZ_CP067235:2875206-2875272 [Escherichia coli]
GGTCTAGAGTCAAGATTAGCCCCCGTGGTGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6HPB

Antitoxin

Source ID Structure

References