Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 2264869..2265701 Replicon chromosome
Accession NZ_CP051219
Organism Escherichia coli strain SFE8

Toxin (Protein)


Gene name yeeV Uniprot ID A0A0D8W767
Locus tag HF527_RS11050 Protein ID WP_000854697.1
Coordinates 2264869..2265243 (-) Length 125 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A0D8WAR2
Locus tag HF527_RS11055 Protein ID WP_001354195.1
Coordinates 2265333..2265701 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HF527_RS11020 2260019..2260672 - 654 WP_001355839.1 ATP-binding cassette domain-containing protein -
HF527_RS11025 2260672..2262207 - 1536 WP_000258506.1 ABC transporter permease -
HF527_RS11030 2262180..2263346 - 1167 WP_001215353.1 ABC transporter substrate-binding protein -
HF527_RS11035 2263566..2264362 - 797 Protein_2157 DUF4942 domain-containing protein -
HF527_RS11040 2264447..2264644 - 198 WP_085975623.1 DUF957 domain-containing protein -
HF527_RS11045 2264720..2264872 - 153 Protein_2159 hypothetical protein -
HF527_RS11050 2264869..2265243 - 375 WP_000854697.1 TA system toxin CbtA family protein Toxin
HF527_RS11055 2265333..2265701 - 369 WP_001354195.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
HF527_RS11060 2265751..2266395 - 645 WP_045146861.1 hypothetical protein -
HF527_RS11065 2266414..2266635 - 222 WP_000692303.1 DUF987 domain-containing protein -
HF527_RS11070 2266698..2267174 - 477 WP_001354455.1 RadC family protein -
HF527_RS11075 2267190..2267669 - 480 WP_000860074.1 antirestriction protein -
HF527_RS11080 2267751..2268569 - 819 WP_168725331.1 DUF945 domain-containing protein -
HF527_RS11085 2268670..2268822 - 153 WP_001696589.1 DUF905 family protein -
HF527_RS11090 2268828..2269505 - 678 WP_001097365.1 hypothetical protein -
HF527_RS11095 2269624..2270508 - 885 WP_001696588.1 50S ribosome-binding GTPase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(19-117)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 14023.07 Da        Isoelectric Point: 7.1881

>T153862 WP_000854697.1 NZ_CP051219:c2265243-2264869 [Escherichia coli]
MKTLPDTHVREASCCPSPVTIWQTLLTRLLDQHYSLTLNDTPFADERVIELHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKYPEAK

Download         Length: 375 bp

>T153862 NZ_CP067235:c2874190-2874083 [Escherichia coli]
ATGACGCTCGCAGAACTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTCTGAT
CGTGAACTCGCTGAATAAGCGGAAGTAA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13708.48 Da        Isoelectric Point: 6.8270

>AT153862 WP_001354195.1 NZ_CP051219:c2265701-2265333 [Escherichia coli]
VSDTLPGTTHHDDNHDRLWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFRDADAYHPDQAFPLPMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCEADTLGSCGYVYLAVYPTPETKK

Download         Length: 369 bp

>AT153862 NZ_CP067235:2874247-2874302 [Escherichia coli]
TCAAGATTAGCCCCCGTGATGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0D8W767

Antitoxin

Source ID Structure
AlphaFold DB A0A0D8WAR2

References