Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | IV | Classification (family/domain) | cptAB/Cpta(toxin) |
Location | 955478..956132 | Replicon | chromosome |
Accession | NZ_CP051219 | ||
Organism | Escherichia coli strain SFE8 |
Toxin (Protein)
Gene name | cptA | Uniprot ID | F4NJ21 |
Locus tag | HF527_RS04665 | Protein ID | WP_000244772.1 |
Coordinates | 955725..956132 (+) | Length | 136 a.a. |
Antitoxin (Protein)
Gene name | cptB | Uniprot ID | S1PPB1 |
Locus tag | HF527_RS04660 | Protein ID | WP_000354046.1 |
Coordinates | 955478..955744 (+) | Length | 89 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
HF527_RS04635 | 950647..951390 | + | 744 | WP_000951964.1 | SDR family oxidoreductase | - |
HF527_RS04640 | 951447..952880 | - | 1434 | WP_001363803.1 | 6-phospho-beta-glucosidase BglA | - |
HF527_RS04645 | 952925..953236 | + | 312 | WP_001182954.1 | N(4)-acetylcytidine aminohydrolase | - |
HF527_RS04650 | 953400..954059 | + | 660 | WP_000250274.1 | hemolysin III family protein | - |
HF527_RS04655 | 954255..955235 | - | 981 | WP_000886095.1 | tRNA-modifying protein YgfZ | - |
HF527_RS04660 | 955478..955744 | + | 267 | WP_000354046.1 | FAD assembly factor SdhE | Antitoxin |
HF527_RS04665 | 955725..956132 | + | 408 | WP_000244772.1 | protein YgfX | Toxin |
HF527_RS04670 | 956172..956693 | - | 522 | WP_001055874.1 | flavodoxin FldB | - |
HF527_RS04675 | 956805..957701 | + | 897 | WP_000806638.1 | site-specific tyrosine recombinase XerD | - |
HF527_RS04680 | 957726..958436 | + | 711 | WP_000715214.1 | bifunctional protein-disulfide isomerase/oxidoreductase DsbC | - |
HF527_RS04685 | 958442..960175 | + | 1734 | WP_000813215.1 | single-stranded-DNA-specific exonuclease RecJ | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 136 a.a. Molecular weight: 16048.02 Da Isoelectric Point: 11.2511
>T153850 WP_000244772.1 NZ_CP051219:955725-956132 [Escherichia coli]
VVLWQSDLRVSWRAQWLSLLIHGLVAAVILLMPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQ
EWCIVKAPWMIKSGMMLRLRSDGGKRQHLWLAADSMDEAEWRDLRRILLQQETQR
VVLWQSDLRVSWRAQWLSLLIHGLVAAVILLMPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQ
EWCIVKAPWMIKSGMMLRLRSDGGKRQHLWLAADSMDEAEWRDLRRILLQQETQR
Download Length: 408 bp
>T153850 NZ_CP067232:4257350-4257457 [Escherichia coli]
ATGACGCTCGCGAAGTTTGCCATGATTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGGATTATTACCGCAGCGAT
TGTCGGCTGGTGGCGTAACCGGAAGTAA
ATGACGCTCGCGAAGTTTGCCATGATTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGGATTATTACCGCAGCGAT
TGTCGGCTGGTGGCGTAACCGGAAGTAA
Antitoxin
Download Length: 89 a.a. Molecular weight: 10547.12 Da Isoelectric Point: 5.1599
>AT153850 WP_000354046.1 NZ_CP051219:955478-955744 [Escherichia coli]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRIFIRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
RERGPVAI
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRIFIRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
RERGPVAI
Download Length: 267 bp
>AT153850 NZ_CP067232:c4257297-4257236 [Escherichia coli]
TGGTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT
TGGTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A0E0XYB4 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A7U9QD57 |