Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | IV | Classification (family/domain) | yeeUV (cbtA-cbeA)/CbtA-CbeA |
Location | 752169..753004 | Replicon | chromosome |
Accession | NZ_CP051219 | ||
Organism | Escherichia coli strain SFE8 |
Toxin (Protein)
Gene name | yeeV | Uniprot ID | A0A1V3VXN0 |
Locus tag | HF527_RS03655 | Protein ID | WP_000854801.1 |
Coordinates | 752627..753004 (+) | Length | 126 a.a. |
Antitoxin (Protein)
Gene name | yeeU | Uniprot ID | A0A1V3VXQ4 |
Locus tag | HF527_RS03650 | Protein ID | WP_001360188.1 |
Coordinates | 752169..752537 (+) | Length | 123 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
HF527_RS03625 | 749290..750108 | + | 819 | WP_001234702.1 | DUF945 domain-containing protein | - |
HF527_RS03630 | 750199..750684 | + | 486 | WP_000214418.1 | antirestriction protein | - |
HF527_RS03635 | 750700..751176 | + | 477 | WP_001186773.1 | RadC family protein | - |
HF527_RS03640 | 751239..751460 | + | 222 | WP_000692323.1 | DUF987 domain-containing protein | - |
HF527_RS03645 | 751475..752119 | + | 645 | WP_000086744.1 | hypothetical protein | - |
HF527_RS03650 | 752169..752537 | + | 369 | WP_001360188.1 | type IV toxin-antitoxin system YeeU family antitoxin | Antitoxin |
HF527_RS03655 | 752627..753004 | + | 378 | WP_000854801.1 | type IV toxin-antitoxin system toxin CbtA | Toxin |
HF527_RS03660 | 753001..753489 | + | 489 | WP_000761658.1 | hypothetical protein | - |
HF527_RS03665 | 753501..753698 | + | 198 | WP_000839269.1 | DUF957 domain-containing protein | - |
HF527_RS03670 | 753783..754628 | + | 846 | Protein_718 | DUF4942 domain-containing protein | - |
HF527_RS03680 | 754928..755434 | + | 507 | WP_000228937.1 | G/U mismatch-specific DNA glycosylase | - |
HF527_RS03685 | 755513..757354 | - | 1842 | WP_000437371.1 | RNA polymerase sigma factor RpoD | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 126 a.a. Molecular weight: 13881.87 Da Isoelectric Point: 7.3219
>T153849 WP_000854801.1 NZ_CP051219:752627-753004 [Escherichia coli]
MKTLPVLPGQAASSRPSPVEIWQILLSQLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTHSQLINSIDILRARRATGLMTRDNYRTVNNITLGKHPGAKQ
MKTLPVLPGQAASSRPSPVEIWQILLSQLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTHSQLINSIDILRARRATGLMTRDNYRTVNNITLGKHPGAKQ
Download Length: 378 bp
>T153849 NZ_CP067232:4256814-4256921 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGACTTTCTGGCACGACCTGGCGGCACCGATCCTGGCGGGGATTATTACCGCAGCGAT
TGTCAGCTGGTGGCGTAACCGGAAGTAA
ATGACGCTCGCGCAGTTTGCCATGACTTTCTGGCACGACCTGGCGGCACCGATCCTGGCGGGGATTATTACCGCAGCGAT
TGTCAGCTGGTGGCGTAACCGGAAGTAA
Antitoxin
Download Length: 123 a.a. Molecular weight: 13563.27 Da Isoelectric Point: 6.2044
>AT153849 WP_001360188.1 NZ_CP051219:752169-752537 [Escherichia coli]
VSDTLSGTTHPDDNHDRPWWGLPCTVTPCFGARLVQEGNQLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGVTCEADTLGSCGYVYLAVYPTPETKK
VSDTLSGTTHPDDNHDRPWWGLPCTVTPCFGARLVQEGNQLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGVTCEADTLGSCGYVYLAVYPTPETKK
Download Length: 369 bp
>AT153849 NZ_CP067232:c4256767-4256701 [Escherichia coli]
TGTCTGGTTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT
TGTCTGGTTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A1V3VXN0 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A1V3VXQ4 |