Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 752169..753004 Replicon chromosome
Accession NZ_CP051219
Organism Escherichia coli strain SFE8

Toxin (Protein)


Gene name yeeV Uniprot ID A0A1V3VXN0
Locus tag HF527_RS03655 Protein ID WP_000854801.1
Coordinates 752627..753004 (+) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A1V3VXQ4
Locus tag HF527_RS03650 Protein ID WP_001360188.1
Coordinates 752169..752537 (+) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HF527_RS03625 749290..750108 + 819 WP_001234702.1 DUF945 domain-containing protein -
HF527_RS03630 750199..750684 + 486 WP_000214418.1 antirestriction protein -
HF527_RS03635 750700..751176 + 477 WP_001186773.1 RadC family protein -
HF527_RS03640 751239..751460 + 222 WP_000692323.1 DUF987 domain-containing protein -
HF527_RS03645 751475..752119 + 645 WP_000086744.1 hypothetical protein -
HF527_RS03650 752169..752537 + 369 WP_001360188.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
HF527_RS03655 752627..753004 + 378 WP_000854801.1 type IV toxin-antitoxin system toxin CbtA Toxin
HF527_RS03660 753001..753489 + 489 WP_000761658.1 hypothetical protein -
HF527_RS03665 753501..753698 + 198 WP_000839269.1 DUF957 domain-containing protein -
HF527_RS03670 753783..754628 + 846 Protein_718 DUF4942 domain-containing protein -
HF527_RS03680 754928..755434 + 507 WP_000228937.1 G/U mismatch-specific DNA glycosylase -
HF527_RS03685 755513..757354 - 1842 WP_000437371.1 RNA polymerase sigma factor RpoD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 13881.87 Da        Isoelectric Point: 7.3219

>T153849 WP_000854801.1 NZ_CP051219:752627-753004 [Escherichia coli]
MKTLPVLPGQAASSRPSPVEIWQILLSQLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTHSQLINSIDILRARRATGLMTRDNYRTVNNITLGKHPGAKQ

Download         Length: 378 bp

>T153849 NZ_CP067232:4256814-4256921 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGACTTTCTGGCACGACCTGGCGGCACCGATCCTGGCGGGGATTATTACCGCAGCGAT
TGTCAGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13563.27 Da        Isoelectric Point: 6.2044

>AT153849 WP_001360188.1 NZ_CP051219:752169-752537 [Escherichia coli]
VSDTLSGTTHPDDNHDRPWWGLPCTVTPCFGARLVQEGNQLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGVTCEADTLGSCGYVYLAVYPTPETKK

Download         Length: 369 bp

>AT153849 NZ_CP067232:c4256767-4256701 [Escherichia coli]
TGTCTGGTTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1V3VXN0

Antitoxin

Source ID Structure
AlphaFold DB A0A1V3VXQ4

References