Detailed information of TA system TA153844

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): yeeUV (cbtA-cbeA)/CbtA-CbeA
• Location: 4481310..4482145
• Replicon: chromosome
• Accession: NZ_CP051218
• Organism: Salmonella sp. SCFS4

Toxin (Protein)

• Gene name: yeeV
• Uniprot ID: A0A1C0Y405
• Locus tag: HF553_RS21705
• Protein ID: WP_001774607.1
• Coordinates: 4481768..4482145 (+)
• Length: 126 a.a.

Antitoxin (Protein)

• Gene name: yeeU
• Uniprot ID: A0A1M2U6P5
• Locus tag: HF553_RS21700
• Protein ID: WP_001774606.1
• Coordinates: 4481310..4481678 (+)
• Length: 123 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HF553_RS21655	4476342..4477022	+	681	WP_032082725.1	WYL domain-containing protein	-
HF553_RS21660	4477170..4477847	+	678	WP_001097305.1	hypothetical protein	-
HF553_RS21665	4477853..4478086	+	234	WP_001278287.1	DUF905 family protein	-
HF553_RS21670	4478185..4479003	+	819	WP_016238867.1	DUF945 domain-containing protein	-
HF553_RS21675	4479003..4479248	+	246	WP_016238868.1	hypothetical protein	-
HF553_RS21680	4479342..4479821	+	480	WP_032152717.1	antirestriction protein	-
HF553_RS21685	4479837..4480313	+	477	WP_001297237.1	RadC family protein	-
HF553_RS21690	4480376..4480597	+	222	WP_000692312.1	DUF987 domain-containing protein	-
HF553_RS21695	4480616..4481260	+	645	WP_001774605.1	hypothetical protein	-
HF553_RS21700	4481310..4481678	+	369	WP_001774606.1	type IV toxin-antitoxin system toxin CbtA	Antitoxin
HF553_RS21705	4481768..4482145	+	378	WP_001774607.1	TA system toxin CbtA family protein	Toxin
HF553_RS21710	4482142..4482633	+	492	WP_171455532.1	hypothetical protein	-
HF553_RS21715	4482709..4483937	+	1229	WP_089541817.1	IS3 family transposase	-
HF553_RS21720	4483978..4484175	+	198	WP_032152719.1	DUF957 domain-containing protein	-
HF553_RS21725	4484260..4485102	+	843	WP_032152755.1	DUF4942 domain-containing protein	-
HF553_RS21730	4485314..4485388	-	75	Protein_4256	helix-turn-helix domain-containing protein	-
HF553_RS21735	4485944..4486696	+	753	WP_023227601.1	non-specific acid phosphatase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	-	-	4440448..4485235	44787

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• CbtA toxin of type IV toxin-antitoxin system (1-112)

Antitoxin

• Antitoxin CbeA (18-117)

Sequences

Toxin

Protein

• Length: 126 a.a.
• Molecular weight: 14218.20 Da
• Isoelectric Point: 7.8045

>T153844 WP_001774607.1 NZ_CP051218:4481768-4482145 [Salmonella sp. SCFS4]
MKTLPDTHVREASRCPPPVTIWQTLLSRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDTVNFLVEKYALIRTDQPGF
SACTRSQLINSIDILRARRATGLMTRDNYRTVNNITQGKHPEAKQ

Nucleotide

• Length: 378 bp

>T153844 NZ_CP067232:3500069-3500320 [Escherichia coli]
ATGCGTACAATTAGCTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTTATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATATAACTCCCTGGAAGAGACGGCTTATC
TACTGCGTTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACGGAAAAGGAC
ATCATTGAGTGA

Antitoxin

Protein

• Length: 123 a.a.
• Molecular weight: 13593.31 Da
• Isoelectric Point: 5.8746

>AT153844 WP_001774606.1 NZ_CP051218:4481310-4481678 [Salmonella sp. SCFS4]
VSDTLSGTTHPDDNHDRPWWGLPCTVTPCFGARLVQEGNQLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCEADTLGSCGYVYLAVYPTPEMKN

Nucleotide

• Length: 369 bp

>AT153844 NZ_CP067232:3500317-3500571 [Escherichia coli]
GTGAAACTAATCTGGTCTGAGGAATCATGGGATGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAACTTATCAAAGATACCCGCAGAACGCCATTTGAAGGTAAGGGGAAGCCAGAACCCCTGAAACATAATTTGTCAG
GTTTCTGGTCCCGACGCATTACAGAGGAGCACCGTCTGGTATACGCGGTTACCGACGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA

Structures

Toxin

• AlphaFold DB: A0A1C0Y405

Antitoxin

• AlphaFold DB: A0A1M2U6P5