Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4315889..4316405 Replicon chromosome
Accession NZ_CP051218
Organism Salmonella sp. SCFS4

Toxin (Protein)


Gene name relE Uniprot ID A0A3V5VNJ7
Locus tag HF553_RS20890 Protein ID WP_000220577.1
Coordinates 4315889..4316173 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID V7ISI8
Locus tag HF553_RS20895 Protein ID WP_000212724.1
Coordinates 4316163..4316405 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HF553_RS20875 4311005..4312657 + 1653 WP_000155050.1 alpha,alpha-phosphotrehalase -
HF553_RS20880 4313066..4315204 + 2139 WP_023226981.1 anaerobic ribonucleoside-triphosphate reductase -
HF553_RS20885 4315421..4315885 + 465 WP_001009173.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
HF553_RS20890 4315889..4316173 - 285 WP_000220577.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HF553_RS20895 4316163..4316405 - 243 WP_000212724.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
HF553_RS20900 4316483..4318396 - 1914 WP_023226980.1 BglG family transcription antiterminator -
HF553_RS20905 4318413..4319153 - 741 WP_000779254.1 KDGP aldolase family protein -
HF553_RS20910 4319150..4320268 - 1119 WP_023137277.1 DgaE family pyridoxal phosphate-dependent ammonia lyase -
HF553_RS20915 4320252..4321385 - 1134 WP_023226979.1 amidohydrolase/deacetylase family metallohydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-82)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 10912.71 Da        Isoelectric Point: 9.8739

>T153843 WP_000220577.1 NZ_CP051218:c4316173-4315889 [Salmonella sp. SCFS4]
MTYELEFDPRALKEWHKLGDTVKAQLKKKLADVLLNPRIDSARLNDLPDCYKIKLKSSGYRLVYQVRDDVVIVFVVAVGK
REHSAVYHDANKRL

Download         Length: 285 bp

>T153843 NZ_CP067232:2986076-2986474 [Escherichia coli]
ATGCTGAAATTCATGCTGGATACCAATATCTGTATTTTCACTATTAAGAATAAACCAGTACATGTCAGAGAGCGGTTTAA
CCTGAATTCTGGCCGGATGTGTATAAGTTCTGTAACATTGATGGAGCTTATCTATGGGGCAGAAAAAAGTCAGATGCCAG
AACGCAATTTGGCGGTTATTGAAGGTTTCGTATCTCGTTTGGTAGTGCTTGATTATGATAGTGCTGCTGCGACGCATACC
GGGCAAATCAGGGCCGAGCTTGCCCGGCAGGGAAGGCCTGTTGGACCTTTTGACCAGATGATAGCGGGACATGCTCGCAG
TCGCGGTTTGATTGTGGTTACCAACAATACCCGAGAGTTTGAGCGAGTGGCGGGAATCAGACTAGAAGACTGGAGCTAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8961.34 Da        Isoelectric Point: 5.0651

>AT153843 WP_000212724.1 NZ_CP051218:c4316405-4316163 [Salmonella sp. SCFS4]
MATLNVRLDDKLKNEAYAVLEKLNITPTEAVRLLFQYVAETGRMPVKTVTLSDSEDALIQTVRERLSSPQKGIKVSLDDL

Download         Length: 243 bp

>AT153843 NZ_CP067232:2985849-2986076 [Escherichia coli]
ATGGAAACTACTGTATTTTTAAGTAATCGCAGTCAGGCCGTCAGATTACCGAAAGCGGTCGCTCTGCCAGAAGACGTTAA
GAAAGTAGAAATTATTGCGATTGGTCGTACAAGAATCATCACTCCCGCCGGTGAGTCCTGGGACAGTTGGTTTGATGGCG
AAAATGTGAGTGCGGATTTTATGGATATCCGTGATCAACCCGCAATGCAGGAAAGGGAATCATTTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3V5VNJ7

Antitoxin

Source ID Structure
AlphaFold DB A0A5H5JRI5

References