Detailed information of TA system TA153839

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): yeeUV (cbtA-cbeA)/CbtA-CbeA
• Location: 3732769..3733604
• Replicon: chromosome
• Accession: NZ_CP051218
• Organism: Salmonella sp. SCFS4

Toxin (Protein)

• Gene name: yeeV
• Uniprot ID: A0A7W4PV54
• Locus tag: HF553_RS18295
• Protein ID: WP_000854821.1
• Coordinates: 3732769..3733146 (-)
• Length: 126 a.a.

Antitoxin (Protein)

• Gene name: yeeU
• Uniprot ID: B7MK11
• Locus tag: HF553_RS18300
• Protein ID: WP_001285610.1
• Coordinates: 3733236..3733604 (-)
• Length: 123 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HF553_RS18265	3728399..3729157	+	759	WP_023227313.1	fimbrial biogenesis chaperone StbE	-
HF553_RS18270	3729205..3729399	-	195	WP_023227314.1	hypothetical protein	-
HF553_RS18275	3730005..3731324	+	1320	WP_000144692.1	site-specific integrase	-
HF553_RS18280	3731417..3732265	-	849	WP_096195002.1	DUF4942 domain-containing protein	-
HF553_RS18285	3732350..3732547	-	198	WP_085949090.1	DUF957 domain-containing protein	-
HF553_RS18290	3732575..3732772	-	198	Protein_3584	hypothetical protein	-
HF553_RS18295	3732769..3733146	-	378	WP_000854821.1	type IV toxin-antitoxin system toxin CbtA	Toxin
HF553_RS18300	3733236..3733604	-	369	WP_001285610.1	type IV toxin-antitoxin system YeeU family antitoxin	Antitoxin
HF553_RS18305	3733684..3733905	-	222	WP_000692350.1	DUF987 domain-containing protein	-
HF553_RS18310	3733992..3734468	-	477	WP_001186711.1	RadC family protein	-
HF553_RS18315	3734484..3734969	-	486	WP_171455520.1	antirestriction protein	-
HF553_RS18320	3735061..3735879	-	819	WP_001610805.1	DUF945 domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	3717212..3745112	27900

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• CbtA toxin of type IV toxin-antitoxin system (1-112)

Antitoxin

• Antitoxin CbeA (19-117)

Sequences

Toxin

Protein

• Length: 126 a.a.
• Molecular weight: 13930.95 Da
• Isoelectric Point: 8.5163

>T153839 WP_000854821.1 NZ_CP051218:c3733146-3732769 [Salmonella sp. SCFS4]
MKTLPVLPGQAASSRPSPVEIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKHPGAKQ

Nucleotide

• Length: 378 bp

>T153839 NZ_CP067232:1955242-1955517 [Escherichia coli]
ATGAGAACCAAGGTACAGGCTTTACGGAAGAAACAAAAAAATACATTGGATCAAATAGTTAAAACTCCTGTTCCTCAAGG
GATCAAGTGGTCTGATATAGAGTCACTGGTTAAAGCATTAGGCGGAGAAATTAAGGAAGGAAGAGGTTCGCGTTGCAAGT
TCATACTAAATATGAGCGTTGCGTGTTTCCATCGGCCTCATCCGTCGCCAGATACCGATAAAGGCGCTGTAGAAAGCGTG
CGTGACTGGTTACTAAGTATAGGGGTAAAACCATGA

Antitoxin

Protein

• Length: 123 a.a.
• Molecular weight: 13606.39 Da
• Isoelectric Point: 6.0618

>AT153839 WP_001285610.1 NZ_CP051218:c3733604-3733236 [Salmonella sp. SCFS4]
VSDTLPGTTLPDDNNDRTWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFSDADSYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCEADTLGSCGYVYMAVYPTPETKK

Nucleotide

• Length: 369 bp

>AT153839 NZ_CP067232:1955514-1955873 [Escherichia coli]
ATGATCAAACTGAAGACGCCAAACTCTATGGAGATTGCCGGGCAACCTGCAGTTATCACTTACGTGCCAGAACTGAATGC
ATTTCGTGGCAAATTCCTGGGCTTGTCAGGTTATTGTGATTTTGTCTCTGACAGCATTCAGGGGCTGCAAAAAGAAGGGG
AACTTTCCCTGCGAGAGTATCTTGAGGATTGTAAAGCTGCGGGTATTGAGCCGTATGCGCGTACAGAAAAGATTAAGACC
TTTACGTTACGCTATCCAGAATCGCTGAGTGAACGCCTTAATAATGCGGCTGCGCAGCAACAAGTCTCTGTTAATACCTA
TATTATTGAAACACTGAATGAGCGTTTGAATCATTTATAA

Structures

Toxin

• AlphaFold DB: A0A7W4PV54