Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | Hha-TomB/- |
Location | 3577381..3578001 | Replicon | chromosome |
Accession | NZ_CP051218 | ||
Organism | Salmonella sp. SCFS4 |
Toxin (Protein)
Gene name | Hha | Uniprot ID | V1H8E6 |
Locus tag | HF553_RS17560 | Protein ID | WP_001280991.1 |
Coordinates | 3577783..3578001 (+) | Length | 73 a.a. |
Antitoxin (Protein)
Gene name | TomB | Uniprot ID | V1H4V6 |
Locus tag | HF553_RS17555 | Protein ID | WP_000344807.1 |
Coordinates | 3577381..3577755 (+) | Length | 125 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
HF553_RS17545 | 3572520..3573713 | + | 1194 | WP_001039202.1 | multidrug efflux RND transporter periplasmic adaptor subunit AcrA | - |
HF553_RS17550 | 3573736..3576885 | + | 3150 | WP_051129102.1 | efflux RND transporter permease AcrB | - |
HF553_RS17555 | 3577381..3577755 | + | 375 | WP_000344807.1 | Hha toxicity modulator TomB | Antitoxin |
HF553_RS17560 | 3577783..3578001 | + | 219 | WP_001280991.1 | hemolysin expression modulator Hha | Toxin |
HF553_RS17565 | 3578180..3578731 | + | 552 | WP_001278793.1 | maltose O-acetyltransferase | - |
HF553_RS17570 | 3578849..3579319 | + | 471 | WP_000136181.1 | membrane protein | - |
HF553_RS17575 | 3579375..3579515 | - | 141 | WP_001197749.1 | type B 50S ribosomal protein L36 | - |
HF553_RS17580 | 3579521..3579781 | - | 261 | WP_000801415.1 | type B 50S ribosomal protein L31 | - |
HF553_RS17585 | 3580006..3581556 | + | 1551 | WP_023210786.1 | EAL domain-containing protein | - |
HF553_RS17595 | 3581787..3582176 | + | 390 | WP_000961285.1 | MGMT family protein | - |
HF553_RS17600 | 3582209..3582778 | - | 570 | WP_000779802.1 | YbaY family lipoprotein | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
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Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 73 a.a. Molecular weight: 8613.97 Da Isoelectric Point: 8.9008
>T153838 WP_001280991.1 NZ_CP051218:3577783-3578001 [Salmonella sp. SCFS4]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR
Download Length: 219 bp
>T153838 NZ_CP067232:1880597-1880704 [Escherichia coli]
ATGACGCTCGCAGAGCTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CGTGAACTGGCTGAACAAACGGAAGTAA
ATGACGCTCGCAGAGCTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CGTGAACTGGCTGAACAAACGGAAGTAA
Antitoxin
Download Length: 125 a.a. Molecular weight: 14453.27 Da Isoelectric Point: 5.1444
>AT153838 WP_000344807.1 NZ_CP051218:3577381-3577755 [Salmonella sp. SCFS4]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYNEDNKLIAQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYNEDNKLIAQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC
Download Length: 375 bp
>AT153838 NZ_CP067232:c1880548-1880485 [Escherichia coli]
GTCTAGATGCAAGATTAGCCCCCGTGGTGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTT
GTCTAGATGCAAGATTAGCCCCCGTGGTGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTT
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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