Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3577381..3578001 Replicon chromosome
Accession NZ_CP051218
Organism Salmonella sp. SCFS4

Toxin (Protein)


Gene name Hha Uniprot ID V1H8E6
Locus tag HF553_RS17560 Protein ID WP_001280991.1
Coordinates 3577783..3578001 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID V1H4V6
Locus tag HF553_RS17555 Protein ID WP_000344807.1
Coordinates 3577381..3577755 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HF553_RS17545 3572520..3573713 + 1194 WP_001039202.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
HF553_RS17550 3573736..3576885 + 3150 WP_051129102.1 efflux RND transporter permease AcrB -
HF553_RS17555 3577381..3577755 + 375 WP_000344807.1 Hha toxicity modulator TomB Antitoxin
HF553_RS17560 3577783..3578001 + 219 WP_001280991.1 hemolysin expression modulator Hha Toxin
HF553_RS17565 3578180..3578731 + 552 WP_001278793.1 maltose O-acetyltransferase -
HF553_RS17570 3578849..3579319 + 471 WP_000136181.1 membrane protein -
HF553_RS17575 3579375..3579515 - 141 WP_001197749.1 type B 50S ribosomal protein L36 -
HF553_RS17580 3579521..3579781 - 261 WP_000801415.1 type B 50S ribosomal protein L31 -
HF553_RS17585 3580006..3581556 + 1551 WP_023210786.1 EAL domain-containing protein -
HF553_RS17595 3581787..3582176 + 390 WP_000961285.1 MGMT family protein -
HF553_RS17600 3582209..3582778 - 570 WP_000779802.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8613.97 Da        Isoelectric Point: 8.9008

>T153838 WP_001280991.1 NZ_CP051218:3577783-3578001 [Salmonella sp. SCFS4]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

>T153838 NZ_CP067232:1880597-1880704 [Escherichia coli]
ATGACGCTCGCAGAGCTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CGTGAACTGGCTGAACAAACGGAAGTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14453.27 Da        Isoelectric Point: 5.1444

>AT153838 WP_000344807.1 NZ_CP051218:3577381-3577755 [Salmonella sp. SCFS4]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYNEDNKLIAQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC

Download         Length: 375 bp

>AT153838 NZ_CP067232:c1880548-1880485 [Escherichia coli]
GTCTAGATGCAAGATTAGCCCCCGTGGTGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4ICG

Antitoxin

Source ID Structure
AlphaFold DB A0A5I5FGI0

References