Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) stbDE/ParE-YafN
Location 2560763..2561285 Replicon chromosome
Accession NZ_CP051218
Organism Salmonella sp. SCFS4

Toxin (Protein)


Gene name stbE Uniprot ID B5F5Y5
Locus tag HF553_RS12465 Protein ID WP_000221343.1
Coordinates 2561001..2561285 (+) Length 95 a.a.

Antitoxin (Protein)


Gene name stbD Uniprot ID V1H457
Locus tag HF553_RS12460 Protein ID WP_000885424.1
Coordinates 2560763..2561011 (+) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HF553_RS12440 2556405..2557871 + 1467 WP_023893409.1 hypothetical protein -
HF553_RS12445 2558488..2558736 + 249 Protein_2438 helix-turn-helix domain-containing protein -
HF553_RS12450 2558847..2559755 - 909 WP_077910000.1 hypothetical protein -
HF553_RS12455 2559906..2560238 - 333 WP_023227504.1 DUF1493 family protein -
HF553_RS12460 2560763..2561011 + 249 WP_000885424.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
HF553_RS12465 2561001..2561285 + 285 WP_000221343.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HF553_RS12470 2561297..2561533 + 237 WP_024148213.1 mRNA endoribonuclease -
HF553_RS12475 2561585..2562664 - 1080 WP_023227502.1 S-adenosylmethionine:tRNA ribosyltransferase-isomerase -
HF553_RS12480 2562857..2563345 - 489 WP_023227501.1 MarR family winged helix-turn-helix transcriptional regulator -
HF553_RS12485 2563390..2564898 + 1509 WP_023227500.1 FAD-dependent oxidoreductase -
HF553_RS12490 2564888..2566129 + 1242 WP_023227499.1 MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 2557920..2567755 9835


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-84)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11075.85 Da        Isoelectric Point: 10.6500

>T153837 WP_000221343.1 NZ_CP051218:2561001-2561285 [Salmonella sp. SCFS4]
MTYKLAFNESALKEWKKLGHTIQEQFKKKLRERLENPRVPASQLHGRKDQYKIKLRGAGYRLVYSVEDEIITVTVIGVGK
RENDAVYKMTRHRS

Download         Length: 285 bp

>T153837 NZ_CP067232:1880114-1880221 [Escherichia coli]
ATGACGCTCGCAGAACTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CGTGAACTGGCTGAATAAGCGGAAATAA

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9090.32 Da        Isoelectric Point: 3.9820

>AT153837 WP_000885424.1 NZ_CP051218:2560763-2561011 [Salmonella sp. SCFS4]
MAFQILTTTAASITELKRDPMGTFNAGDGAPVAILNRNEPAFYCVPPALYAHLMDILEDEELGRIIDERANERVIEVNID
DL

Download         Length: 249 bp

>AT153837 NZ_CP067232:c1880057-1880002 [Escherichia coli]
TCAAGAATGGCCCCCGTGATGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5H5JSW4

Antitoxin

Source ID Structure
AlphaFold DB A0A5I0WPN5

References