Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 1190783..1191597 Replicon chromosome
Accession NZ_CP051218
Organism Salmonella sp. SCFS4

Toxin (Protein)


Gene name TacT3 Uniprot ID A0A4Y6MAM1
Locus tag HF553_RS05845 Protein ID WP_023227563.1
Coordinates 1190783..1191310 (-) Length 176 a.a.

Antitoxin (Protein)


Gene name TacA3 Uniprot ID A0A4Y6M833
Locus tag HF553_RS05850 Protein ID WP_072162154.1
Coordinates 1191307..1191597 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HF553_RS05815 1187084..1187494 + 411 WP_023227565.1 hypothetical protein -
HF553_RS05820 1187693..1187860 + 168 Protein_1144 transposase -
HF553_RS05825 1188068..1188736 + 669 WP_000445914.1 hypothetical protein -
HF553_RS05830 1188763..1189257 + 495 WP_023227564.1 hypothetical protein -
HF553_RS05835 1189502..1190158 - 657 WP_000420452.1 protein-serine/threonine phosphatase -
HF553_RS05840 1190487..1190710 + 224 Protein_1148 IS5/IS1182 family transposase -
HF553_RS05845 1190783..1191310 - 528 WP_023227563.1 GNAT family N-acetyltransferase Toxin
HF553_RS05850 1191307..1191597 - 291 WP_072162154.1 DUF1778 domain-containing protein Antitoxin
HF553_RS05855 1191867..1192045 - 179 Protein_1151 IS3 family transposase -
HF553_RS05860 1192286..1192612 + 327 WP_000393302.1 hypothetical protein -
HF553_RS05865 1192885..1193232 - 348 WP_001669174.1 DUF1493 family protein -
HF553_RS05870 1193217..1193666 - 450 WP_000381610.1 membrane protein -
HF553_RS05875 1194097..1194540 - 444 WP_000715096.1 SPI-1 type III secretion system invasion lipoprotein InvH -
HF553_RS05880 1194996..1195646 + 651 WP_001674874.1 type III secretion system transcriptional activator InvF -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - invH / invF / invG / invE / invA / invB 1189502..1200959 11457
- flank IS/Tn - - 1190570..1190710 140


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Vibrio phage ICP1, Orf50

(1-95)


Sequences

Toxin        


Download         Length: 176 a.a.        Molecular weight: 19099.93 Da        Isoelectric Point: 9.6420

>T153828 WP_023227563.1 NZ_CP051218:c1191310-1190783 [Salmonella sp. SCFS4]
MMFTDWHEAAIGKTHNRMNFDCGDADLNQFLQRHARQNHEKGTTKTYVALDNSDVTRIHGFYSVSPASLIYAQVPGAISK
GLGRYDVPVFRLGRLAVDKSMQGQGLGAQLLLSAGKRCIQAALQVGSVALLIDAKNKQVCDWYKGFGAVPLNDQPLSLLL
SFKTLYAALSASGRL

Download         Length: 528 bp

>T153828 NZ_CP067228:c4320-4072 [Paracoccus sp. MC1862]
ATGCTGATGATCGTCTGGGATGAGCCGAAGCGGCAAACGAACCTCGCCAAGCACGGCTTGGATTTTGCCGATCTGGATGA
GGGGTTCTTTCTGGCCTCGCTTGTCGTCCCGGCAAAGGACGGTCGGAACATGGCCATAGGCCGCCTGGCGGACGGTACGA
TCGCCGTGGTGTTCGCCACTCTGGGCACTGAAGGGGTTTCGGTGATCTCGATGCGGCCGGCCAGCGAAAGGGAAAGGAGC
CTGCTATGA

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10664.54 Da        Isoelectric Point: 8.5779

>AT153828 WP_072162154.1 NZ_CP051218:c1191597-1191307 [Salmonella sp. SCFS4]
MKTMPQIAIESNERLSLRVSTDAKKLIVRAAAIQQTNLTDFVVSNVLPVAQKIVDAAERVYLTERDTKMIMEILDNPPAP
NEKLLAAAFALPDMKK

Download         Length: 291 bp

>AT153828 NZ_CP067228:c4036-3785 [Paracoccus sp. MC1862]
ATGATCGCCAGCGATCCCGACGCCCCGGAAGCAAGCGATGACCAGCTCGCCCAGGCCAAGCCGTTCACCGAGGCCTTTCC
GGCCCTGGCTGAGGCTATGCGCAAGAATGTTGGGGGGCGGCCGAAAGCGGAAAACCCGAAGGTTGCCGTGTCCCTGCGCT
TGGACCAGGACGTTGTGGCCCGGTTCAAGGCCAGCGGGCCGGGCTGGCAGACCCGGATAAACAGCGCCTTGCGCGACGCT
GCCGGGTTGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A4Y6MAM1

Antitoxin

Source ID Structure
AlphaFold DB A0A4Y6M833

References