Detailed information of TA system TA153827

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-VagC
• Location: 1034909..1035534
• Replicon: chromosome
• Accession: NZ_CP051218
• Organism: Salmonella sp. SCFS4

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: HF553_RS05145
• Protein ID: WP_000911337.1
• Coordinates: 1035136..1035534 (+)
• Length: 133 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: C0PXM4
• Locus tag: HF553_RS05140
• Protein ID: WP_000557545.1
• Coordinates: 1034909..1035136 (+)
• Length: 76 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HF553_RS05110	1029954..1031471	+	1518	WP_000003339.1	lysine--tRNA ligase	-
HF553_RS05115	1031547..1032092	-	546	WP_000133994.1	isopentenyl-diphosphate Delta-isomerase	-
HF553_RS05120	1032357..1033115	+	759	WP_000244318.1	peptidoglycan DD-metalloendopeptidase family protein	-
HF553_RS05130	1033400..1034206	-	807	WP_010989071.1	DUF1460 domain-containing protein	-
HF553_RS05135	1034481..1034741	-	261	WP_023227725.1	hypothetical protein	-
HF553_RS05140	1034909..1035136	+	228	WP_000557545.1	toxin-antitoxin system antitoxin VapB	Antitoxin
HF553_RS05145	1035136..1035534	+	399	WP_000911337.1	tRNA(fMet)-specific endonuclease VapC	Toxin
HF553_RS05150	1036338..1036874	+	537	WP_023227726.1	STM3031 family outer membrane protein	-
HF553_RS05155	1036921..1037553	+	633	WP_023227727.1	YfdX family protein	-
HF553_RS05160	1038272..1038859	+	588	WP_023227728.1	fimbrial protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	1033400..1044727	11327

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (5-123)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 133 a.a.
• Molecular weight: 15037.43 Da
• Isoelectric Point: 7.7785

>T153827 WP_000911337.1 NZ_CP051218:1035136-1035534 [Salmonella sp. SCFS4]
MLKFMLDTNTCIFTIKNKPEHIRERFNLNTSRMCISSITLMELIYGAEKSLAPERNLAVVEGFISRLEVLDYDTQAAIHT
GQIRAELARKGTPVGPYDQMIAGHARSRGLVVVTNNLREFERIPGIRIEDWC

Nucleotide

• Length: 399 bp

>T153827 NZ_CP067226:c66427-66020 [Paracoccus sp. MC1862]
ATGATCCGACGCCTTCTCGACACCAACGTTGTGATTGCACTTGTCGGGCGACGCTCCGCCGAACTGTTCAGGCGGGTTGA
AGCCTCCGAGCCGGGCTCGCTCGCCATTTCCTCCATCGTGGCGCATGAACTCTGGTACGGCGCCTATCGCAGTCAGAAGG
TCGCGTTCAACCTGGAAACCCTGCGGCTTCTCTTCGCCGACCTGGCTATCGTCGATCTCGACCCTGAGGACGCGCGAGCC
GCAGGGGAGATCCGGGCAGAGCTTGCGCGGCAGGGCACGCCCATCGGGCCCTATGATGTGCTGATCGCCGGACAGGCCAA
GGCGCGAAGCCTGACTCTGGTGACGAACAACACCGGCGAATTCTCTCGCGTCGCCGGGCTGAGCCTCGAAGACTGGACCG
CTGCATGA

Antitoxin

Protein

• Length: 76 a.a.
• Molecular weight: 8500.48 Da
• Isoelectric Point: 5.0053

>AT153827 WP_000557545.1 NZ_CP051218:1034909-1035136 [Salmonella sp. SCFS4]
MHTTLFFSNRTQAVRLPKSISFPDDVKHVEIIAVGRSRIITPVGESWDSWFDGEGASTDFMSTREQPAVQEREGF

Nucleotide

• Length: 228 bp

>AT153827 NZ_CP067226:c66684-66424 [Paracoccus sp. MC1862]
ATGCCCCATATTGCCAAGGTGTTCCGCTCGGGCAACTCCCAGGCTGTCCGGCTGCCGAAGGACTTCCGCCTTGAGGCCAG
CGAGGTCGAGATCTCGCGGGAGGGCGATGCCCTGATCCTGCGCCCGAAACTGGCGACAGACAGGCCTTGGGCGTCGCTGC
ACGCAGCAGTCGAGCGAGGCTTCAGCGAGGATTTCCTGACCAGCGGCCGGGAACAGCCCGCCGAACAGCAGCGTCCCGAC
CTTGACCAGCTCTTTTCATGA

Structures

Antitoxin

• AlphaFold DB: A0A0R9MGW6