Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 1024022..1024682 Replicon chromosome
Accession NZ_CP051218
Organism Salmonella sp. SCFS4

Toxin (Protein)


Gene name cptA Uniprot ID A0A3V4SJP5
Locus tag HF553_RS05080 Protein ID WP_000244755.1
Coordinates 1024269..1024682 (+) Length 138 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S5MU13
Locus tag HF553_RS05075 Protein ID WP_000351186.1
Coordinates 1024022..1024288 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HF553_RS05055 1020331..1020642 + 312 WP_001182976.1 N(4)-acetylcytidine aminohydrolase -
HF553_RS05060 1020806..1021465 + 660 WP_000250289.1 hemolysin III family protein -
HF553_RS05065 1021723..1022709 + 987 WP_023226548.1 IS110 family transposase -
HF553_RS05070 1022792..1023772 - 981 WP_017441090.1 tRNA-modifying protein YgfZ -
HF553_RS05075 1024022..1024288 + 267 WP_000351186.1 FAD assembly factor SdhE Antitoxin
HF553_RS05080 1024269..1024682 + 414 WP_000244755.1 protein YgfX Toxin
HF553_RS05085 1024735..1025256 - 522 WP_001055885.1 flavodoxin FldB -
HF553_RS05090 1025369..1026265 + 897 WP_000434302.1 site-specific tyrosine recombinase XerD -
HF553_RS05095 1026289..1027002 + 714 WP_000745614.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
HF553_RS05100 1027008..1028741 + 1734 WP_023227724.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 138 a.a.        Molecular weight: 16164.10 Da        Isoelectric Point: 10.2118

>T153826 WP_000244755.1 NZ_CP051218:1024269-1024682 [Salmonella sp. SCFS4]
VVLWQSDLRVSWRAQWISLLIHGLVAAVILLMPWPLSYTPLWMILLSLVVFDCVRSQRRINTCQGEIKLLMDGRLRWQGQ
DWTLLHPPWLLKSGMVLRLRAESGRHQHLWLAADSMEEAEWRELRRILLQQPISGQH

Download         Length: 414 bp

>T153826 NZ_CP067225:c2577193-2576786 [Paracoccus sp. MC1862]
ATGATCCGACACCTTCTCGACACCAACGTTGTGATTGCACTTGTCGGGCGACGCTCCGCCGAACTGCTCAGGCGGGTTGA
AGCCTCCGAGCCGGGCTCGCTCGCCATTTCCTCCATCGTGGCGCATGAACTCTGGTACGGGGCCTATCGCAGTCAGAAAG
TTGCCTTCAACCTGGAGACCCTGCGGCTTCTCTTCGCCGACCTCGCCATCATTGACCTCGACCCTGAGGACGCGCGAGCC
GCAGGGGAGATCCGGGTAGAGCTTGCGCGGCAGGGCACGCCCATCGGGCCCTATGATGTGCTGATCGCCGGACAGGCCAA
AGCGCGAAACCTGACGCTGGTGACGAACAACATCGGCGAATTCTCTCGCGTCGCCGGGCTGAGCCTCGAAGACTGGACCG
CTGCATGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10550.05 Da        Isoelectric Point: 6.0783

>AT153826 WP_000351186.1 NZ_CP051218:1024022-1024288 [Salmonella sp. SCFS4]
MDIHNKARIHWACRRGMRELDISIMPFFEHEYDSLSDEEKRIFVRLLQSDDPDLFNWLMNHGKPADAELEQMVRLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT153826 NZ_CP067225:c2577450-2577190 [Paracoccus sp. MC1862]
ATGCCCCATATTGCCAAGGTGTTCCGCTCGGGCAACTCCCAGGCTGTCCGGCTGCCGAAGGACTTCCGCCTTGAGGCCAG
CGAGGTCGAGATCTCGCGGGAAGGCGATGCCCTGATCCTGCGCCCGAAACTGGCGACAGACAGGCCTTGGGCGTCGCTGC
ACGCAGCAGTCGAGCGAGGCTTCAGCGAGGATTTCCTGACCAGCGGCCGGGAACAGCCCGCCGAACAGCAGCGTCCCGAC
CTTGACCAGCTCTTTTCATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3V4SJP5

Antitoxin

Source ID Structure
AlphaFold DB A0A5I0YWH4

References