Detailed information of TA system TA153825

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): yeeUV (cbtA-cbeA)/CbtA-CbeA
• Location: 754172..755007
• Replicon: chromosome
• Accession: NZ_CP051218
• Organism: Salmonella sp. SCFS4

Toxin (Protein)

• Gene name: yeeV
• Uniprot ID: A0A1V3VXN0
• Locus tag: HF553_RS03655
• Protein ID: WP_000854801.1
• Coordinates: 754630..755007 (+)
• Length: 126 a.a.

Antitoxin (Protein)

• Gene name: yeeU
• Uniprot ID: A0A1V3VXQ4
• Locus tag: HF553_RS03650
• Protein ID: WP_001360188.1
• Coordinates: 754172..754540 (+)
• Length: 123 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HF553_RS03620	750963..751196	+	234	WP_001117566.1	DUF905 family protein	-
HF553_RS03625	751286..752104	+	819	WP_001234397.1	DUF945 domain-containing protein	-
HF553_RS03630	752196..752681	+	486	WP_024214936.1	antirestriction protein	-
HF553_RS03635	752697..753173	+	477	WP_001384029.1	RadC family protein	-
HF553_RS03640	753242..753463	+	222	WP_000692334.1	DUF987 domain-containing protein	-
HF553_RS03645	753478..754122	+	645	WP_000086744.1	hypothetical protein	-
HF553_RS03650	754172..754540	+	369	WP_001360188.1	type IV toxin-antitoxin system YeeU family antitoxin	Antitoxin
HF553_RS03655	754630..755007	+	378	WP_000854801.1	type IV toxin-antitoxin system toxin CbtA	Toxin
HF553_RS03660	755004..755492	+	489	WP_000761658.1	hypothetical protein	-
HF553_RS03665	755504..755701	+	198	WP_000839269.1	DUF957 domain-containing protein	-
HF553_RS03670	755786..756631	+	846	Protein_720	DUF4942 domain-containing protein	-
HF553_RS03675	756890..757903	-	1014	WP_015386347.1	tyrosine-type recombinase/integrase	-
HF553_RS03680	758130..758744	-	615	WP_015386349.1	phage repressor protein CI	-
HF553_RS03685	758846..759082	+	237	WP_015386350.1	hypothetical protein	-
HF553_RS03690	759117..759626	+	510	WP_015386351.1	phage regulatory CII family protein	-
HF553_RS03695	759634..759834	+	201	WP_015386352.1	DUF2724 domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	rfaE	752196..803551	51355

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• CbtA toxin of type IV toxin-antitoxin system (1-112)

Antitoxin

• Antitoxin CbeA (18-117)

Sequences

Toxin

Protein

• Length: 126 a.a.
• Molecular weight: 13881.87 Da
• Isoelectric Point: 7.3219

>T153825 WP_000854801.1 NZ_CP051218:754630-755007 [Salmonella sp. SCFS4]
MKTLPVLPGQAASSRPSPVEIWQILLSQLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTHSQLINSIDILRARRATGLMTRDNYRTVNNITLGKHPGAKQ

Nucleotide

• Length: 378 bp

>T153825 NZ_CP067174:c4527-4279 [Paracoccus aestuarii]
ATGCTGATGATCACTTGGGACGCGCCGAAGCGGCAGAGTAACCTTGCCAAGCACGGCTTAGACTTTGCCGATCTAGACGA
AGCCTTCTTTCTGGCCTCCGTCGTGGTTCCAGCGAAAGCAGGCCGGCACATGGCAATCGGTCGCCTCGCAGATGGGACTG
TGGCTGTGGTCTTTGCAGCCTTGGGCACCGAGGGGGTTTCGGTGATCTCGATGCGCCCTGCCAGCGCCAAGGAGAGGAGC
CTGCTATGA

Antitoxin

Protein

• Length: 123 a.a.
• Molecular weight: 13563.27 Da
• Isoelectric Point: 6.2044

>AT153825 WP_001360188.1 NZ_CP051218:754172-754540 [Salmonella sp. SCFS4]
VSDTLSGTTHPDDNHDRPWWGLPCTVTPCFGARLVQEGNQLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGVTCEADTLGSCGYVYLAVYPTPETKK

Nucleotide

• Length: 369 bp

>AT153825 NZ_CP067174:c4282-3992 [Paracoccus aestuarii]
ATGAGCCGACAGCACCTGACCGAAGAACAGATCCAGCGCATGATTGCCAGCGATCCCGAGGCACCGGAAGCGACGGCGGA
CCAGCTCGCCCAGGCTCGGCCCTTCACCGAGGCCTTCCCAGCCCTGTCCGACGCTATGCGCCGCAACATGGGCGGGCGCC
CCAAGGCCGAGAACCCAAAGGTAGCTGTCTCGCTTCGCCTGGATCAGGACGTGGTGGCCCGGTTCAAGGAAAGCGGTCCA
GGCTGGCAGACCCGGATGAACCGCGCCTTGCGCGAAGCAGCTGGGCTCTGA

Structures

Toxin

• AlphaFold DB: A0A1V3VXN0

Antitoxin

• AlphaFold DB: A0A1V3VXQ4