Detailed information of TA system TA153824

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): yeeUV (cbtA-cbeA)/CbtA-CbeA
• Location: 97188..98023
• Replicon: chromosome
• Accession: NZ_CP051218
• Organism: Salmonella sp. SCFS4

Toxin (Protein)

• Gene name: yeeV
• Uniprot ID: -
• Locus tag: HF553_RS00485
• Protein ID: WP_001565141.1
• Coordinates: 97188..97565 (-)
• Length: 126 a.a.

Antitoxin (Protein)

• Gene name: yeeU
• Uniprot ID: -
• Locus tag: HF553_RS00490
• Protein ID: WP_171455491.1
• Coordinates: 97655..98023 (-)
• Length: 123 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HF553_RS00445	92309..93340	-	1032	WP_023227688.1	virulence RhuM family protein	-
HF553_RS00450	93428..93550	-	123	WP_001583388.1	DUF4942 domain-containing protein	-
HF553_RS00455	93681..94070	-	390	WP_023227687.1	AAA family ATPase	-
HF553_RS00460	94205..94368	-	164	Protein_91	hypothetical protein	-
HF553_RS00465	94746..95090	+	345	WP_023227686.1	hypothetical protein	-
HF553_RS00470	95567..96409	-	843	WP_001565143.1	DUF4942 domain-containing protein	-
HF553_RS00475	96494..96691	-	198	WP_000839256.1	DUF957 domain-containing protein	-
HF553_RS00480	96703..97191	-	489	WP_171455490.1	hypothetical protein	-
HF553_RS00485	97188..97565	-	378	WP_001565141.1	TA system toxin CbtA family protein	Toxin
HF553_RS00490	97655..98023	-	369	WP_171455491.1	type IV toxin-antitoxin system YeeU family antitoxin	Antitoxin
HF553_RS00495	98098..98319	-	222	WP_000692303.1	DUF987 domain-containing protein	-
HF553_RS00500	98388..98864	-	477	WP_001186725.1	RadC family protein	-
HF553_RS00505	98880..99365	-	486	WP_032236571.1	antirestriction protein	-
HF553_RS00510	99457..100275	-	819	WP_032236570.1	DUF945 domain-containing protein	-
HF553_RS00515	100366..100599	-	234	WP_021543798.1	DUF905 family protein	-
HF553_RS00520	100678..101133	-	456	WP_021543797.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	flank	IS/Tn	-	-	92018..92191	173

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• CbtA toxin of type IV toxin-antitoxin system (1-112)

Antitoxin

• Antitoxin CbeA (19-117)

Sequences

Toxin

Protein

• Length: 126 a.a.
• Molecular weight: 14246.27 Da
• Isoelectric Point: 7.2920

>T153824 WP_001565141.1 NZ_CP051218:c97565-97188 [Salmonella sp. SCFS4]
MKTLPDTHVREASRCPSPVTIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SICPRSQLINSIDILRARRATGLMTRDNYRMVNNITQGKHPEAQQ

Nucleotide

• Length: 378 bp

>T153824 NZ_CP067170:124854-125249 [Paracoccus aestuarii]
ATGAGCGTTGAGTTCGTCGACACGAACGTCATTCTCTATCTGCTGGATGACGGCCCCAAGGCCGACCGCGCCGAAGCCAT
TCTGGCTCAGGGCCCCCGTATCAGTGTGCAGGTGCTGAATGAGGCGATGGTCAATTGTCGTCGCAAGGCGGGCATGGACT
GGAACGACACGGCCAGTTTTTTGGCAGGGGTGCGGGCGCTGTGCCCTGTCGAGGATCTCACTCTGCGCACCCATGACGTC
GGTCGCGCGCTTGCCGAGCGCTATGGGTTTTCGGTCTATGACGCGATGATCGTCGCGGCAGCCTTGATTGCCGGGTGCGA
GACCTTGTGGACGGAGGACATGCATGCAGGCCTCCTGGTCGAAGGCCAGCTGCGGTTGGTCAATCCCTTCGCCTGA

Antitoxin

Protein

• Length: 123 a.a.
• Molecular weight: 13600.42 Da
• Isoelectric Point: 6.7389

>AT153824 WP_171455491.1 NZ_CP051218:c98023-97655 [Salmonella sp. SCFS4]
VSDTLPGTTHPDDNHDRLWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFSNADAYHLDQAFALLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCEADPLGSCGYVYLAVYPTPETKK

Nucleotide

• Length: 369 bp

>AT153824 NZ_CP067170:124637-124864 [Paracoccus aestuarii]
ATGCAGGTCGCAAAATGGGGCAACTCACTGGCTGTTCGGCTCCCTGCGGAACTGGTGCGGGACATGGGCCTCAAAGAGGG
AGATCAGATCGATCTGCTGCCGGATGACGGCCCTCTGAGGATCCGGCGCCTGCCCCGTGCCGACGAGGTGCTGGACGGGT
TGCGTCGCTTTCGCGGCAGACTGCCCGCCTCCGAACGGCTGAGCCGCGACGCCGCGCATGAGCGTTGA