Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4278554..4279070 Replicon chromosome
Accession NZ_CP051213
Organism Salmonella enterica strain SCSW714

Toxin (Protein)


Gene name relE Uniprot ID C0Q7A9
Locus tag HGB43_RS20730 Protein ID WP_000220578.1
Coordinates 4278554..4278838 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID V7ISI8
Locus tag HGB43_RS20735 Protein ID WP_000212724.1
Coordinates 4278828..4279070 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HGB43_RS20715 (4273670) 4273670..4275322 + 1653 WP_023138463.1 alpha,alpha-phosphotrehalase -
HGB43_RS20720 (4275731) 4275731..4277869 + 2139 WP_000187818.1 anaerobic ribonucleoside-triphosphate reductase -
HGB43_RS20725 (4278086) 4278086..4278550 + 465 WP_017441190.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
HGB43_RS20730 (4278554) 4278554..4278838 - 285 WP_000220578.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HGB43_RS20735 (4278828) 4278828..4279070 - 243 WP_000212724.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
HGB43_RS20740 (4279148) 4279148..4281061 - 1914 WP_023203318.1 BglG family transcription antiterminator -
HGB43_RS20745 (4281078) 4281078..4281818 - 741 WP_023138827.1 KDGP aldolase family protein -
HGB43_RS20750 (4281815) 4281815..4282933 - 1119 WP_023138828.1 DgaE family pyridoxal phosphate-dependent ammonia lyase -
HGB43_RS20755 (4282917) 4282917..4284050 - 1134 WP_023138829.1 amidohydrolase/deacetylase family metallohydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 10854.67 Da        Isoelectric Point: 10.0482

>T153820 WP_000220578.1 NZ_CP051213:c4278838-4278554 [Salmonella enterica]
MTYELEFDPRALKEWHKLGDTVKAQLKKKLADVLLNPRIDSARLNGLPDCYKIKLKSSGYRLVYQVRDDVVIVFVVAVGK
REHSAVYHDANKRL

Download         Length: 285 bp

>T153820 NZ_CP067141:c81032-80757 [Paracoccus saliphilus]
GTGCCTGAAGTCGAATGGAAGGCCCCGGCGGTCGCGGACCTGGTGGCGATTGTCGAGTACATCTCGGACGACAACCCGGA
TGCCGCGCTTGCCCTGCTTGAGGAAATACAGGGCAAGGTGGCGCAGCTCCCGGCGCATCCGAAACGCTGCCGTCCCGACA
GGGTGGAGGGTACACGGGAACTGATGGTCCGGCCCAACTACATCGCGGTCTATGCCGAAACCGCGGCGACGGTCACGGTG
CTGCGCGTACTTCACGCCGCGCAAATGTGGCCCTGA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8961.34 Da        Isoelectric Point: 5.0651

>AT153820 WP_000212724.1 NZ_CP051213:c4279070-4278828 [Salmonella enterica]
MATLNVRLDDKLKNEAYAVLEKLNITPTEAVRLLFQYVAETGRMPVKTVTLSDSEDALIQTVRERLSSPQKGIKVSLDDL

Download         Length: 243 bp

>AT153820 NZ_CP067141:c81318-81025 [Paracoccus saliphilus]
ATGCCCGCCCAAACCTCGATGCTCCATGTTCGCGTGGACGACCAGCTCAAGGCACAGGCAGCCGATGCCCTGTCCGGGGT
CGGCCTGACGCTTTCGGATGCCGTGCGTATCCTGCTGACCCGCGTTGCCGCCGAAGGGGGCTTGCCCGCCGGTCTGACTG
CGGACCCGGATGCCTATGACGCCTGGTTCCGTGCCAAGGTGCAGGAGGCACTTGCCGATCTCCGCCCGGCGACACCGCAT
GACCAGGTGATGCAGGGCGCCGGCGCCCTGATCGACGGGAAGCGCCGTGCCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3Z1E876

Antitoxin

Source ID Structure
AlphaFold DB A0A5H5JRI5

References