Detailed information of TA system TA153819

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): ykfI-yfjZ/CbtA-CbeA
• Location: 4217348..4218074
• Replicon: chromosome
• Accession: NZ_CP051213
• Organism: Salmonella enterica strain SCSW714

Toxin (Protein)

• Gene name: ykfI
• Uniprot ID: -
• Locus tag: HGB43_RS20415
• Protein ID: WP_112324576.1
• Coordinates: 4217348..4217689 (-)
• Length: 114 a.a.

Antitoxin (Protein)

• Gene name: yfjZ
• Uniprot ID: A0A5T2TUW7
• Locus tag: HGB43_RS20420
• Protein ID: WP_023138494.1
• Coordinates: 4217733..4218074 (-)
• Length: 114 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HGB43_RS20380 (4212883)	4212883..4212999	+	117	Protein_4015	transposase	-
HGB43_RS20385 (4213225)	4213225..4214242	-	1018	Protein_4016	IS110 family transposase	-
HGB43_RS20390 (4214309)	4214309..4215291	+	983	Protein_4017	IS3 family transposase	-
HGB43_RS20395 (4215415)	4215415..4215723	-	309	WP_001199743.1	CcdB family protein	-
HGB43_RS20400 (4215726)	4215726..4215965	-	240	WP_001118105.1	type II toxin-antitoxin system CcdA family antitoxin	-
HGB43_RS20405 (4216074)	4216074..4216322	-	249	WP_000168385.1	ribbon-helix-helix domain-containing protein	-
HGB43_RS20410 (4216399)	4216399..4217232	-	834	WP_023138496.1	DUF4942 domain-containing protein	-
HGB43_RS20415 (4217348)	4217348..4217689	-	342	WP_112324576.1	TA system toxin CbtA family protein	Toxin
HGB43_RS20420 (4217733)	4217733..4218074	-	342	WP_023138494.1	type IV toxin-antitoxin system YeeU family antitoxin	Antitoxin
HGB43_RS20425 (4218097)	4218097..4218318	-	222	WP_023138493.1	DUF987 family protein	-
HGB43_RS20430 (4218315)	4218315..4218815	-	501	WP_023138492.1	DNA repair protein RadC	-
HGB43_RS20435 (4218828)	4218828..4219649	-	822	WP_023138491.1	DUF932 domain-containing protein	-
HGB43_RS20440 (4219734)	4219734..4220648	-	915	WP_023138490.1	hypothetical protein	-
HGB43_RS20445 (4220713)	4220713..4220916	-	204	WP_023137300.1	hypothetical protein	-
HGB43_RS20450 (4220933)	4220933..4221079	-	147	WP_023892166.1	hypothetical protein	-
HGB43_RS20455 (4221152)	4221152..4221865	-	714	WP_023138489.1	WYL domain-containing protein	-
HGB43_RS20460 (4222220)	4222220..4222513	-	294	WP_023138487.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	4195643..4240821	45178

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• CbtA toxin of type IV toxin-antitoxin system (2-109)

Antitoxin

• Antitoxin CbeA (11-109)

Sequences

Toxin

Protein

• Length: 114 a.a.
• Molecular weight: 13106.02 Da
• Isoelectric Point: 9.8633

>T153819 WP_112324576.1 NZ_CP051213:c4217689-4217348 [Salmonella enterica]
MQTQYNHPHRATPSQLSPVEIWQKLLTHLLAKHYGLELSDTPFSVEKVIQEHIDAGITLANAVNFIVEKYELVRIDRKGF
SWQEQSPHLRAVDILRARQATGLLRRQRYLAAH

Nucleotide

• Length: 342 bp

>T153819 NZ_CP067137:10764-11390 [Paracoccus fistulariae]
ATGAGCCGATACACTGATCGGTTCACAGCTCTCCTCGATGCCTGCGTTCTTGGCGGCGCGCTTCGAAGAAACATGCTTCT
GAGCCTGGCCGAGGCCGGCTTGTTCCGGCCTCGGTGGAGCAGTCGCATTCTTGACGAGACCCAGAAAGCGATCGCCCAGA
TCATCAAGGGCGCAACCGATGGTTCCCGGCAAAGGGCGGCAATCGAAGCAGCATTCCCTGAAGCTATGGTGACTGGTTAT
GAGATATTCGAAGACAGGCTCGCGTTGCCCGATCCAGACGACAACCACGTGCTGGCAGCGGCAATAGCGACGTCTGCTTC
AGTCATCGTGACGGACAATCTTGCCGACTTTCCTTTTGCGGTTCTGGACGCGCACGCCATCCAGGCGATTTCCGCCGACG
ACTTCATCGCCGATACAATCGAGCTGGATCCCTCGGAGGCCATTCTGGCCCTGCGTCGGATGCGGGAGCGCTTCAAGAAC
CCGGCGCTCGATGTTGCGGCTTTGATTCACAAGTCAGAAGCGCAGGGCCTATTACAGGTTGGGTCCATGCTTCCTGAGAG
GAGCAAGGACCATGACGATTTCGAACGAACTGCTGGACGAGCTGCTGAAAGGCTGCAAACGGCCTGA

Antitoxin

Protein

• Length: 114 a.a.
• Molecular weight: 12690.40 Da
• Isoelectric Point: 6.2121

>AT153819 WP_023138494.1 NZ_CP051213:c4218074-4217733 [Salmonella enterica]
MDTNETQSTPVWGLRNDVFPSFGARLVQEGNHLHYLADRAGIYGEFTPAQLQTLDVVFPMFIKHMEAALRTGALNPREAR
RFTTELRGITCEADTCGSFGYVYLSLYPTIVKS

Nucleotide

• Length: 342 bp

>AT153819 NZ_CP067137:10303-10767 [Paracoccus fistulariae]
ATGAACGCCCTCAGAAAAGAGGCGTTCTTTGATCGTTTACCCGACGAGGTCGAGATCAAGAACGCCGAGCAACTCAGAAC
GATTGTCGCCTCCCAGATCAAGGAAGGCGAACCGACGAAGCTGTCACTTGCCCTAGAAGGCGGCGAAGTTCAAACTGTGA
CGCTTGCGCCTGCCTTGACGGCTTCGCTGCTCGAAGTGCTGCGGCTCGTGTCGAGCGGTCGCGGATTTCGGATGATCCCC
GTAGAGTCAGAGCTGACCACGCAGCAGGCAGCAGACCTTCTCAATGTGTCCCGCCCGTTCCTGGTGAAGCTTCTCGAGGA
AGGTAAGATTCCGTTTGCGAAGACCGGCCGCCATCGCCGGGTTCGTGCAGACGATCTTTTTGCCTACAAGAATGAGCGTG
ACGCGTCTCGCTCGGATACTTTGAGTGACCTTGCCGCAATGGACGCGGAAGAAGGTCTTGTATGA

Structures

Antitoxin

• AlphaFold DB: A0A5T2TUW7