Detailed information of TA system TA153818

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): ccdAB/CcdA(antitoxin)
• Location: 4215415..4215965
• Replicon: chromosome
• Accession: NZ_CP051213
• Organism: Salmonella enterica strain SCSW714

Toxin (Protein)

• Gene name: ccdB
• Uniprot ID: M7RJ32
• Locus tag: HGB43_RS20395
• Protein ID: WP_001199743.1
• Coordinates: 4215415..4215723 (-)
• Length: 103 a.a.

Antitoxin (Protein)

• Gene name: ccdA
• Uniprot ID: M7RP97
• Locus tag: HGB43_RS20400
• Protein ID: WP_001118105.1
• Coordinates: 4215726..4215965 (-)
• Length: 80 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HGB43_RS20380 (4212883)	4212883..4212999	+	117	Protein_4015	transposase	-
HGB43_RS20385 (4213225)	4213225..4214242	-	1018	Protein_4016	IS110 family transposase	-
HGB43_RS20390 (4214309)	4214309..4215291	+	983	Protein_4017	IS3 family transposase	-
HGB43_RS20395 (4215415)	4215415..4215723	-	309	WP_001199743.1	CcdB family protein	Toxin
HGB43_RS20400 (4215726)	4215726..4215965	-	240	WP_001118105.1	type II toxin-antitoxin system CcdA family antitoxin	Antitoxin
HGB43_RS20405 (4216074)	4216074..4216322	-	249	WP_000168385.1	ribbon-helix-helix domain-containing protein	-
HGB43_RS20410 (4216399)	4216399..4217232	-	834	WP_023138496.1	DUF4942 domain-containing protein	-
HGB43_RS20415 (4217348)	4217348..4217689	-	342	WP_112324576.1	TA system toxin CbtA family protein	-
HGB43_RS20420 (4217733)	4217733..4218074	-	342	WP_023138494.1	type IV toxin-antitoxin system YeeU family antitoxin	-
HGB43_RS20425 (4218097)	4218097..4218318	-	222	WP_023138493.1	DUF987 family protein	-
HGB43_RS20430 (4218315)	4218315..4218815	-	501	WP_023138492.1	DNA repair protein RadC	-
HGB43_RS20435 (4218828)	4218828..4219649	-	822	WP_023138491.1	DUF932 domain-containing protein	-
HGB43_RS20440 (4219734)	4219734..4220648	-	915	WP_023138490.1	hypothetical protein	-
HGB43_RS20445 (4220713)	4220713..4220916	-	204	WP_023137300.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	4195643..4240821	45178

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin CcdB (2-101)

Antitoxin

• Post-segregation antitoxin CcdA (9-79)

Sequences

Toxin

Protein

• Length: 103 a.a.
• Molecular weight: 11845.67 Da
• Isoelectric Point: 6.7228

>T153818 WP_001199743.1 NZ_CP051213:c4215723-4215415 [Salmonella enterica]
MQYMVYRNKGNSKAYPYLLDVQSDIIDELHTRMVIPLFPVSRLVNNPVKRLTPTLNVEGNDYLVMTHEMASIRLSQIGDE
VMDVRSHRQTIKNALDFIFDGF

Nucleotide

• Length: 309 bp

>T153818 NZ_CP067124:3302758-3303039 [Paracoccus alcaliphilus]
ATGTTACAAAGCACCAGAGGAAAGCTGGCCGCCGATGCGGTAAAGGATCGGTTCGGCAAGGGCTTCCCTTCTGATCTGGT
GAAGCGCACCCGTGCGATGCTGTCGGCGCTTCATGCGGCCACTGTGCTTGAAGACCTGCGGTTTCCTCCGGGAAACCATC
TTGAGGAACTGAAAGGCGACCGGGCGGGGCAACATTCCGTCCGCATCAACAAACAATGGCGCATCTGCTTTGTGTGGACG
GAAACCGGCCCCGCGGATGTCGAAATCGTGGACTACCATTGA

Antitoxin

Protein

• Length: 80 a.a.
• Molecular weight: 8719.90 Da
• Isoelectric Point: 6.4633

>AT153818 WP_001118105.1 NZ_CP051213:c4215965-4215726 [Salmonella enterica]
MPGMSVRHKKTVSVTLEPALLQQARDAGINLSAVLTAALKEEISATGVERWKAENRAGLQELNRITDEHGLLSDDYRTF

Nucleotide

• Length: 240 bp

>AT153818 NZ_CP067124:3303053-3303343 [Paracoccus alcaliphilus]
ATGATCGCTCTTACCAATCCGTCGCACCCCGGCGAAGTGCTTGCCGAACTGTTCCTGCAACCGCTCGACATGAGCGCGGG
CGCGTTGGCCAAGCGTCTGGACGTCCCGCGCACCCGGATAGAACGGCTTGTGAAGGGCGTGACGCCCGTCACCGCTGACA
CGGCGCTGCGGCTGTCGGCGTTCTTCGGGAATACCGCCGAATTCTGGATGAACCTTCAGCGTGCCTATGATCTCACCGAA
GCGCGCGGCCATGTGGACGTTTCCGGTATCAAGCCGCTGCAAGCGGCCTGA

Structures

Toxin

• AlphaFold DB: A0A6C6Z9V9

Antitoxin

• AlphaFold DB: A0A5H9SZK8