Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) shpAB/BrnT-BrnA
Location 4167148..4167724 Replicon chromosome
Accession NZ_CP051213
Organism Salmonella enterica strain SCSW714

Toxin (Protein)


Gene name shpA Uniprot ID M7RG88
Locus tag HGB43_RS20210 Protein ID WP_001131963.1
Coordinates 4167437..4167724 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name shpB Uniprot ID A0A6C6ZAR7
Locus tag HGB43_RS20205 Protein ID WP_000063143.1
Coordinates 4167148..4167450 (-) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HGB43_RS20190 (4163658) 4163658..4165808 + 2151 WP_000379928.1 pyruvate/proton symporter BtsT -
HGB43_RS20195 (4165903) 4165903..4166106 + 204 WP_000460616.1 YbdD/YjiX family protein -
HGB43_RS20200 (4166117) 4166117..4167073 + 957 WP_000187840.1 GTPase -
HGB43_RS20205 (4167148) 4167148..4167450 - 303 WP_000063143.1 BrnA antitoxin family protein Antitoxin
HGB43_RS20210 (4167437) 4167437..4167724 - 288 WP_001131963.1 BrnT family toxin Toxin
HGB43_RS20215 (4167993) 4167993..4168907 - 915 WP_023138517.1 restriction endonuclease -
HGB43_RS20220 (4169105) 4169105..4172614 + 3510 WP_023138516.1 type I restriction-modification system endonuclease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Ribonuclease toxin, BrnT, of type II toxin-antitoxin system

(7-88)

Antitoxin

BrnA antitoxin of type II toxin-antitoxin system

(40-93)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11294.80 Da        Isoelectric Point: 9.5894

>T153817 WP_001131963.1 NZ_CP051213:c4167724-4167437 [Salmonella enterica]
MPMEFEWDANKAKSNLRKHGVRFEDAVLVFDDPRHLSRQERYENGEYRWQTLGLVHGIVVILVAHSVRFESGFEVIRIIS
ARKADRKERNRYEHG

Download         Length: 288 bp

>T153817 NZ_CP067124:c496626-496111 [Paracoccus alcaliphilus]
ATGACGCAGGGTATGCAGCCCTTACGCGCGCCCGTGCCGCTGAGTGACGATCATCTGATCGACGGCTTCGCATCCGGGGC
AACGACGCTTGATACTTGGCTGAAGCGCAAAGCCCGCGCCAATCAGGTGTCTGGCGCGTCGCGGGCCTATGTGCTGTGCC
GGGGCCAGCGGGCCGTCGGTTTCTATGCGCTGGCGGCCGGATCGGTCAGCCACGATCTGGCACCCCGCAGGCTGCGGCAG
AATATGCCCGACCCCATCCCGGTCATCGTTCTGGGGCGTTTGGCGGTGGATGTGTCTGAGCAGGGCAATGGTCTCGGCCG
GGCACTGCTGCGCGATGCCGTGCTGCGGATCACGGCGGCGGCGCATGAGGTCGGCATCGCGGCCATTTTGGTTCACGCCC
TGAACGAGCGTGCCAAGGCATTTTATGTCGGGGCCGGTTTTGCCGAGACGGTGCTGGAGCCGATGACGCTGTTTCTGCGC
ATCAAGGACGCGCGGGCGCTGATTGGCGAGGGCTGA

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11402.01 Da        Isoelectric Point: 10.1293

>AT153817 WP_000063143.1 NZ_CP051213:c4167450-4167148 [Salmonella enterica]
MSMVKHKRGNASALSAQHEAELKALVKKSDDEIDYSDIPASEDGQWSEAVRGKFFRPLKTQASVRIDADVMEWLKRPGKG
YQTRLNAILREAMLREQNKK

Download         Length: 303 bp

>AT153817 NZ_CP067124:c496916-496623 [Paracoccus alcaliphilus]
ATGGCCGCCGTAACATCCAAGGAGGACGCCCCGCGTCGTTCACTGATCAATCTTCGCGTCACCCCGCGTGACCGCGATCT
GATCGACCGTGCCGCAGCAGCCCTTGGCAAGAACCGCTCGGAGTTCATGATGGAGGCCAGCCGACAGGCGGCTGAGGATG
CGTTGCTCGACCGCACCGCATTCCGACTGGATGCCGAGCAGTTCAGCGCCTTCATGGCACAGCTCGATGCACCGCCTGCG
CCGAATGAACGGCTGGGCAAGCTGCTGGCCACGCCCGCGCCATGGGAGAGATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7VD7

Antitoxin

Source ID Structure
AlphaFold DB A0A6C6ZAR7

References