153815

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) stbDE/ParE-YafN
Location 2495782..2496304 Replicon chromosome
Accession NZ_CP051213
Organism Salmonella enterica strain SCSW714

Toxin (Protein)


Gene name stbE Uniprot ID V7IL40
Locus tag HGB43_RS12155 Protein ID WP_000221345.1
Coordinates 2496020..2496304 (+) Length 95 a.a.

Antitoxin (Protein)


Gene name stbD Uniprot ID V1H457
Locus tag HGB43_RS12150 Protein ID WP_000885424.1
Coordinates 2495782..2496030 (+) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HGB43_RS12130 (2491629) 2491629..2492537 - 909 WP_023138150.1 LysR family transcriptional regulator -
HGB43_RS12135 (2492950) 2492950..2493138 + 189 WP_001276021.1 DUF29 family protein -
HGB43_RS12140 (2493413) 2493413..2493745 - 333 WP_023138149.1 DUF1493 family protein -
HGB43_RS23920 (2494152) 2494152..2494259 - 108 Protein_2389 IS110 family transposase -
HGB43_RS12145 (2494624) 2494624..2495013 + 390 WP_001044696.1 hypothetical protein -
HGB43_RS23925 (2495016) 2495016..2495369 + 354 WP_000418733.1 hypothetical protein -
HGB43_RS12150 (2495782) 2495782..2496030 + 249 WP_000885424.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
HGB43_RS12155 (2496020) 2496020..2496304 + 285 WP_000221345.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HGB43_RS12160 (2496475) 2496475..2496864 + 390 WP_000194089.1 RidA family protein -
HGB43_RS12165 (2496922) 2496922..2497995 - 1074 WP_023138148.1 S-adenosylmethionine:tRNA ribosyltransferase-isomerase -
HGB43_RS12170 (2498188) 2498188..2498676 - 489 WP_023138147.1 MarR family winged helix-turn-helix transcriptional regulator -
HGB43_RS12175 (2498721) 2498721..2500229 + 1509 WP_023138146.1 FAD-dependent oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 2488757..2503086 14329


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-84)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11043.79 Da        Isoelectric Point: 10.6500

>T153815 WP_000221345.1 NZ_CP051213:2496020-2496304 [Salmonella enterica]
MTYKLAFNESALKEWKKLGHTIQEQFKKKLRERLENPRVPASQLHGRKDQYKIKLRGAGYRLVYSVEDEIITVTVIGVGK
RENDAVYKVTRHRS

Download         Length: 285 bp

>T153815 NZ_CP067124:380802-381200 [Paracoccus alcaliphilus]
ATGAGCGCTGACTTTTTCGATACCAACGTCATCCTGTATCTGCTCGATGATGGACCCAAGGCAGATCGGTCTGTCGAGTT
GCTGGCAAAGGGCGGACTGATCAGTGTTCAGGTGCTGAATGAGACCCTTGTGAACTGCATCAGGAAAGCCGGCATGTCAT
GGCGGGACGCGGGCGCTTTCCTCGCCGGGGTGCGAGATCTGTGCGACGTGACCGCCCTCTCGGCCGAGATACACGATGTT
GGCCTGGCTCTCGGCGAACGGTACGGTTTTTCGGTCTATGACGCGATGATCGTCGCGGCCGCGCTGACCAGCGGCTGCGA
ACGGCTTTACACAGAGGACCTTCAGCACGGTCAGTTGATCGAAGGTAGCCTGCGGATCGTCAGTCCATTCCGGGAATGA

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9090.32 Da        Isoelectric Point: 3.9820

>AT153815 WP_000885424.1 NZ_CP051213:2495782-2496030 [Salmonella enterica]
MAFQILTTTAASITELKRDPMGTFNAGDGAPVAILNRNEPAFYCVPPALYAHLMDILEDEELGRIIDERANERVIEVNID
DL

Download         Length: 249 bp

>AT153815 NZ_CP067124:380585-380812 [Paracoccus alcaliphilus]
ATGCATGTCGCCAAATGGGGAAATTCGCTGGCTGTCAGGCTGCCTGCTGACCTGGTGCGCGAGCTTGGTCTGAAGGCCGG
CGACGAGATCGAGCTGAAACGCGCTGATGATGGCCTGGCCATCCGCCGTCGCCCCTCGGCAGACGATGTGCTGGAAGATC
TGCGCCGTTTCCGGGGGCGACTCCCTGCATCTCAGCGACTGAGCCGCGACGCCGCAAATGAGCGCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5Y2FFA8

Antitoxin

Source ID Structure
AlphaFold DB A0A5I0WPN5

References