Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 1079134..1079948 Replicon chromosome
Accession NZ_CP051213
Organism Salmonella enterica strain SCSW714

Toxin (Protein)


Gene name TacT3 Uniprot ID A0A3G3DUX8
Locus tag HGB43_RS05155 Protein ID WP_000971653.1
Coordinates 1079134..1079661 (-) Length 176 a.a.

Antitoxin (Protein)


Gene name TacA3 Uniprot ID M7S6I2
Locus tag HGB43_RS05160 Protein ID WP_000855694.1
Coordinates 1079658..1079948 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HGB43_RS05125 (1075435) 1075435..1075833 + 399 Protein_1010 cytoplasmic protein -
HGB43_RS05130 (1076044) 1076044..1076262 + 219 Protein_1011 hypothetical protein -
HGB43_RS05135 (1076419) 1076419..1077087 + 669 WP_023137848.1 hypothetical protein -
HGB43_RS05140 (1077114) 1077114..1077608 + 495 WP_000424947.1 hypothetical protein -
HGB43_RS05145 (1077853) 1077853..1078509 - 657 WP_000420449.1 protein-serine/threonine phosphatase -
HGB43_RS05150 (1078859) 1078859..1079061 + 203 Protein_1015 IS5/IS1182 family transposase -
HGB43_RS05155 (1079134) 1079134..1079661 - 528 WP_000971653.1 GNAT family N-acetyltransferase Toxin
HGB43_RS05160 (1079658) 1079658..1079948 - 291 WP_000855694.1 DUF1778 domain-containing protein Antitoxin
HGB43_RS05165 (1080218) 1080218..1080418 - 201 Protein_1018 IS3 family transposase -
HGB43_RS05170 (1080659) 1080659..1080985 + 327 WP_000393297.1 hypothetical protein -
HGB43_RS05175 (1081257) 1081257..1081604 - 348 WP_001555786.1 DUF1493 family protein -
HGB43_RS05180 (1081589) 1081589..1082038 - 450 WP_000381616.1 hypothetical protein -
HGB43_RS05185 (1082457) 1082457..1082900 - 444 WP_000715096.1 SPI-1 type III secretion system invasion lipoprotein InvH -
HGB43_RS05190 (1083357) 1083357..1084007 + 651 WP_023166786.1 type III secretion system transcriptional activator InvF -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - invH / invF / invG / invE / invA / invB 1078921..1089320 10399
- flank IS/Tn - - 1078921..1079061 140


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Vibrio phage ICP1, Orf50

(1-95)


Sequences

Toxin        


Download         Length: 176 a.a.        Molecular weight: 19043.87 Da        Isoelectric Point: 9.7032

>T153805 WP_000971653.1 NZ_CP051213:c1079661-1079134 [Salmonella enterica]
MMFTDWHEAAIGKTHNRMNFDCGDADLNQFLQRHARQNHEKGTTKTYVALDNSDVTRIHGFYSVSPASLIYAQVPGAISK
GLGRHDVPVFRLGRLAVDKSMQGQGLGAQLLLSAGKRCIQAALQVGGVALLIDAKNKQVCDWYKGFGAVPLNDQPLSLLL
SFKTLYAALSASGRL

Download         Length: 528 bp

>T153805 NZ_CP067101:c4350398-4350111 [Bradyrhizobium diazoefficiens]
ATGGGCGAGAAGCTGACGACTTATGATCCGGCCGAGGACCTTCAGTCCGACGAGGCCATTGCCGTCTTTATGGAAGAGGC
ATTCAAGACGGAAGATGCAGCCTATATCGCACATGCGCTTGGCGTCGTCGCCCGCGCCAAGGGCATGACGCAGATCGCCA
AGGAGACAGGCCTGTCTCGCGAGCAGCTCTATCGCTCGTTCAGTACTAACGGCAATCCGACACTGAAAACGACGATAGCG
GTGATGAAAGCGCTTGGAATCGAACTCACGGCCAAGCCGCACGTCTAG

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10664.50 Da        Isoelectric Point: 6.3133

>AT153805 WP_000855694.1 NZ_CP051213:c1079948-1079658 [Salmonella enterica]
MKTMPQIAIESNERLSLRVSTDAKKLIVRAAAIQQTNLTDFVVSNVLPVAQKIVDAAERVYLTERDTQMIMEILDNPPAP
NEKLLAAAFALPDMKK

Download         Length: 291 bp

>AT153805 NZ_CP067101:c4350696-4350400 [Bradyrhizobium diazoefficiens]
GTGGTTGAACTCAAGCAGACCGAAACGTTTCGGAAGTGGCGATCGCGACTCAAGGATGAGCGTGCCAAAGCACTGATCGC
GTCGCGATTGGACCGGTTGGCCCTAGGCCACGCAGGCGATGTCGAGCCGGTGGGCGGTGGAATAAGCGAACTGCGTATCC
ATCACGGCCCCGGCTATCGCATCTATTTTCAGAAGCAGGGCGGCTTGATCATCGTTTTGCTGTGCGGTGGCGACAAGAGC
ACGCAGGCGAAAGACATCAAGGCGGCCAAACGCCTTGCCGAGACGTGGAGCGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3G3DUX8

Antitoxin

Source ID Structure
AlphaFold DB A0A3V8SJE7

References