Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 913227..913887 Replicon chromosome
Accession NZ_CP051213
Organism Salmonella enterica strain SCSW714

Toxin (Protein)


Gene name cptA Uniprot ID Q57K70
Locus tag HGB43_RS04410 Protein ID WP_000244756.1
Coordinates 913474..913887 (+) Length 138 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S5MU13
Locus tag HGB43_RS04405 Protein ID WP_000351186.1
Coordinates 913227..913493 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HGB43_RS04385 (909155) 909155..910588 - 1434 WP_001230140.1 6-phospho-beta-glucosidase BglA -
HGB43_RS04390 (910747) 910747..911058 + 312 WP_001182970.1 N(4)-acetylcytidine aminohydrolase -
HGB43_RS04395 (911222) 911222..911881 + 660 WP_000250289.1 hemolysin III family protein -
HGB43_RS04400 (911997) 911997..912977 - 981 WP_000874176.1 tRNA-modifying protein YgfZ -
HGB43_RS04405 (913227) 913227..913493 + 267 WP_000351186.1 FAD assembly factor SdhE Antitoxin
HGB43_RS04410 (913474) 913474..913887 + 414 WP_000244756.1 protein YgfX Toxin
HGB43_RS04415 (913940) 913940..914461 - 522 WP_001055885.1 flavodoxin FldB -
HGB43_RS04420 (914574) 914574..915470 + 897 WP_000434303.1 site-specific tyrosine recombinase XerD -
HGB43_RS04425 (915494) 915494..916207 + 714 WP_000745614.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
HGB43_RS04430 (916213) 916213..917946 + 1734 WP_000813387.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 138 a.a.        Molecular weight: 16183.15 Da        Isoelectric Point: 10.7537

>T153804 WP_000244756.1 NZ_CP051213:913474-913887 [Salmonella enterica]
VVLWQSDLRVSWRAQWISLLIHGLVAAVILLMPWPLSYTPLWMILLSLVVFDCVRSQRRINTCQGEIKLLMDGRLRWQGQ
DWTLLRPPWLLKSGMVLRLRAESGRHQHLWLAADSMEEAEWRELRRILLQQPISGQH

Download         Length: 414 bp

>T153804 NZ_CP067101:c4110124-4109726 [Bradyrhizobium diazoefficiens]
CTGATGGTGCTCGATACCTCTGCAATTATCGCGACCGTAACCAACGAGCCAGATGGGCAACGCTATCGGACAGCCATGTT
GGATGCTGATAGCTTGTCGATGTCGGCAATAGCCGTATTGGAAACCAAGATCGTTCTCTCCGCTCGTTTCGGATCGGCGG
CCGTCACGTTCTTTGACGAGTTGCTGGCGACTGCCGGGATTATCGTCGTGCCGTTCGACGACGATATGGCGAAAAGCGCT
TTCGAGGCGTTTCAGCGTTTCGGTAAGGGTGGAGGACATCCTGCGCAGCTCAACATCGTTGATTGCGCGGTCTACGCTCT
GGCGAAAGCGCGTTCGCAGCCACTCCTCTTTAAAGGAGCCGACTTTGCCAGGACAGATGTTGTTGTGGCGTTGACCTGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10550.05 Da        Isoelectric Point: 6.0783

>AT153804 WP_000351186.1 NZ_CP051213:913227-913493 [Salmonella enterica]
MDIHNKARIHWACRRGMRELDISIMPFFEHEYDSLSDEEKRIFVRLLQSDDPDLFNWLMNHGKPADAELEQMVRLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT153804 NZ_CP067101:c4110363-4110121 [Bradyrhizobium diazoefficiens]
ATGAACATCCGTTCCGCGAAAGTTGACGAGCTTGTCCAGCGTCTCGCCCGCCTGACGGGGGAAGATATCGAGACTGCGCT
GGAACGCGCCATTGAGGAGCGCTTGTCTCGTATCGGCTCGCCGGTCGCCGATAGAAGGGCCGCCCTGACGTCGTTCTTCG
AACGGACCGCTAGCTTGCCCGTTGTGGATTCCCGGTCTGCTGACGAAATCCTTGGTTATGACCGCTTCGGGCTGCCGTCC
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3Z1E9V5

Antitoxin

Source ID Structure
AlphaFold DB A0A5I0YWH4

References