Detailed information of TA system TA153803

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): phd-doc/Doc-RelB
• Location: 387550..388136
• Replicon: chromosome
• Accession: NZ_CP051213
• Organism: Salmonella enterica strain SCSW714

Toxin (Protein)

• Gene name: doc
• Uniprot ID: A0A5T2TYR8
• Locus tag: HGB43_RS01770
• Protein ID: WP_023138592.1
• Coordinates: 387768..388136 (+)
• Length: 123 a.a.

Antitoxin (Protein)

• Gene name: phd
• Uniprot ID: M7SDJ3
• Locus tag: HGB43_RS01765
• Protein ID: WP_001520924.1
• Coordinates: 387550..387771 (+)
• Length: 74 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HGB43_RS01740 (382570)	382570..383679	+	1110	WP_000822977.1	high-affinity branched-chain amino acid ABC transporter substrate-binding protein LivK	-
HGB43_RS01745 (383739)	383739..384665	+	927	WP_000003007.1	high-affinity branched-chain amino acid ABC transporter permease LivH	-
HGB43_RS01750 (384662)	384662..385939	+	1278	WP_000803764.1	branched chain amino acid ABC transporter permease LivM	-
HGB43_RS01755 (385936)	385936..386703	+	768	WP_000082083.1	high-affinity branched-chain amino acid ABC transporter ATP-binding protein LivG	-
HGB43_RS01760 (386705)	386705..387418	+	714	WP_000416114.1	high-affinity branched-chain amino acid ABC transporter ATP-binding protein LivF	-
HGB43_RS01765 (387550)	387550..387771	+	222	WP_001520924.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
HGB43_RS01770 (387768)	387768..388136	+	369	WP_023138592.1	type II toxin-antitoxin system death-on-curing family toxin	Toxin
HGB43_RS01775 (388395)	388395..389711	+	1317	WP_000624747.1	sn-glycerol-3-phosphate ABC transporter substrate-binding protein UgpB	-
HGB43_RS01780 (389816)	389816..390703	+	888	WP_023138593.1	sn-glycerol-3-phosphate ABC transporter permease UgpA	-
HGB43_RS01785 (390700)	390700..391545	+	846	WP_000572196.1	sn-glycerol-3-phosphate ABC transporter permease UgpE	-
HGB43_RS01790 (391547)	391547..392617	+	1071	WP_001646570.1	sn-glycerol-3-phosphate import ATP-binding protein UgpC	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	382570..393354	10784

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Fido domain (25-86)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-49)

Sequences

Toxin

Protein

• Length: 123 a.a.
• Molecular weight: 13563.81 Da
• Isoelectric Point: 6.7252

>T153803 WP_023138592.1 NZ_CP051213:387768-388136 [Salmonella enterica]
MTLQLISAEEIIQFHDRLLRVTPGVTGMSDPGRAEALMYRVLNQIEYEGVTDVWLLAAMHLLAISRGHIFNDGNKRTALF
ITLLFLKRNGISLAANPDFVDMTVDAAAGRLTLEQIAVRLRA

Nucleotide

• Length: 369 bp

>T153803 NZ_CP067101:3746158-3746511 [Bradyrhizobium diazoefficiens]
TTGGCAACGAAGTCTGGTGACCATTGCCCGGAGGCCGGCGATTTCATCTGGATCGATCTGGATCCCACGGTCGGCCACGA
ACAAAGCGGCCGGCGACCTGCCATCGTGGTATCGCCGCGCAGCTACAATGCGGCAGCGGGCCTTTGCGTGATCTGCCCGA
TCACCAGCCGCGTGCGCGGCTATCCATTCGAAGCCGTGTTGCCCGAAGGTGCAGGCCTACGCGGCGCCGTTCTCGCAGAC
CAACCCCGGAGCATCTCCTGGGAGAAACGACCGATCGCGCATGCCGGACGGGCACCTGACATCCTGCTCACCGAAGTCCG
CGAACGGTTGGCTGCGCTGCTGGGAATCGATTGA

Antitoxin

Protein

• Length: 74 a.a.
• Molecular weight: 8152.14 Da
• Isoelectric Point: 5.0775

>AT153803 WP_001520924.1 NZ_CP051213:387550-387771 [Salmonella enterica]
MRTVNYSEARQNLAEVLESAVTGGPVTITRRGHKSAVIISAEEFERYQTARMDDEFAAIMAVHGNELRELADK

Nucleotide

• Length: 222 bp

>AT153803 NZ_CP067101:3745923-3746177 [Bradyrhizobium diazoefficiens]
ATGAAGGTGGCATTTCAGAAGTGGGGCAACAGCCTTGCGCTGCGCGTGCCGAAGGCATTCGCCGACGAAATCGGGGCGCG
CGACGGCCGGGCTGCGGAGATGACCGTGAACAACGGAAAGCTGGTGATCGAGATCGCGCTGCCCAAGCGGCGCAAACGCC
GCTATGCGCTCGACGAACTGGTTGCCGGGATCACGCCGGACAATCGTCATGACGAGATCGATTGGGGGCCGGCCGTTGGC
AACGAAGTCTGGTGA

Structures

Toxin

• AlphaFold DB: A0A5T2TYR8

Antitoxin

• AlphaFold DB: A0A6C6Z871