Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 212232..212992 Replicon chromosome
Accession NZ_CP051213
Organism Salmonella enterica strain SCSW714

Toxin (Protein)


Gene name tacT Uniprot ID A0A620G002
Locus tag HGB43_RS00975 Protein ID WP_023138210.1
Coordinates 212507..212992 (+) Length 162 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID Q8Z2B2
Locus tag HGB43_RS00970 Protein ID WP_000965889.1
Coordinates 212232..212519 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HGB43_RS00955 (210517) 210517..210854 - 338 Protein_191 tyrosine-type recombinase/integrase -
HGB43_RS00960 (211095) 211095..211718 - 624 WP_000082043.1 hypothetical protein -
HGB43_RS00965 (211775) 211775..212020 - 246 WP_023138211.1 hypothetical protein -
HGB43_RS00970 (212232) 212232..212519 + 288 WP_000965889.1 DUF1778 domain-containing protein Antitoxin
HGB43_RS00975 (212507) 212507..212992 + 486 WP_023138210.1 GNAT family N-acetyltransferase Toxin
HGB43_RS00980 (213363) 213363..213902 - 540 WP_000047148.1 copper-binding periplasmic metallochaperone CueP -
HGB43_RS00985 (214075) 214075..214287 - 213 WP_000014594.1 RNA chaperone/antiterminator CspA -
HGB43_RS00990 (214575) 214575..214865 - 291 WP_000455790.1 HTH-type transcriptional regulator -
HGB43_RS00995 (215304) 215304..216014 + 711 WP_023138209.1 DUF3053 domain-containing protein -
HGB43_RS01000 (216064) 216064..217038 - 975 WP_023138208.1 glyoxylate/hydroxypyruvate reductase GhrB -
HGB43_RS01005 (217268) 217268..217930 - 663 WP_000747548.1 OmpA family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(31-152)

Antitoxin

Vibrio phage ICP1, Orf50

(13-89)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17643.31 Da        Isoelectric Point: 9.8719

>T153802 WP_023138210.1 NZ_CP051213:212507-212992 [Salmonella enterica]
VGRVTAPEPLSAFHQVAEFVSGEAVLDDWLKQKGLKNQALGAARTFVVCKKDTKQVAGFYSLATGSVNHTEATGNLRRNM
PDPIPVIILARLAVDLSSHGKGLGADLLHDAVLRCYRVAENIGVRAIMVHALTEEAKNFYIHHGFKSSQTQQRTLFLRLP
Q

Download         Length: 486 bp

>T153802 NZ_CP067101:c3092642-3092361 [Bradyrhizobium diazoefficiens]
GTGCGGCAGACCAGACATTTTTCGGAGTGGCTGGACCGCCTCAAGGACGCCAATGCGGTCGCCCGGATCACGGCTCGCAT
TCGCCGCATGGAGTTGGACAATCCCGACGACAGCAAGAACGTGGGCCGCAACGTCCGAGAAATGCGCATCGACTACGGCG
CGGGCTACCGGATCTATTATGTGCAGCACGGAACGCAGATCATGATTCTGCTATGTGGCGGCGACAAGCGGACGCAACGA
CAAGACATCAAGCTAGCCCAGCAACTAGCGGAGACATTGTGA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10964.59 Da        Isoelectric Point: 4.6811

>AT153802 WP_000965889.1 NZ_CP051213:212232-212519 [Salmonella enterica]
MLYKGCLMKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILETACRAAENVILDRRVFNFNDEQYEEFINLLDAPVADD
PVIEKLLARKPQWDV

Download         Length: 288 bp

>AT153802 NZ_CP067101:c3092361-3092011 [Bradyrhizobium diazoefficiens]
ATGCCAAAGGTAGTAAAAACGACGGCCAAAACGGCATCCAAGACGACACGTTTCGACGCCGCCGACTATCTCGACACTGA
AGAGCGCCAGGCGGCCTATATCGCGGCCGCGCTGGAAACCGGCGACGCCGATTTCGTGCGCGACGCGCTCGGCCTCGTCG
CGCGAGCGCGCGGCATGAGCACGATAGCAAAGAAGGCCGGCTTAAACCGCGAAAGTTTGTACAAGGCGCTCGGAGAGACC
GGAAATCCCGAGTTCGGGACGGTCATGCGCATTGTCGGGGCGTTGGGCCTGACACTATCAGCCCAACCCGCGACAAGCGG
ACGAATGTCAAAGCGCCATCGCGCCGCCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A620G002

Antitoxin

Source ID Structure
AlphaFold DB A0A752RW74

References