Detailed information of TA system TA153791

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): tad-ata/COG5606-COG4679
• Location: 965576..966281
• Replicon: chromosome
• Accession: NZ_CP051206
• Organism: Dolichospermum flos-aquae CCAP 1403/13F

Toxin (Protein)

• Gene name: tad
• Uniprot ID: -
• Locus tag: HGD76_RS04995
• Protein ID: WP_168695139.1
• Coordinates: 965576..965953 (+)
• Length: 126 a.a.

Antitoxin (Protein)

• Gene name: ata
• Uniprot ID: -
• Locus tag: HGD76_RS05000
• Protein ID: WP_168695140.1
• Coordinates: 965958..966281 (+)
• Length: 108 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HGD76_RS04965	960763..962610	-	1848	WP_168695135.1	CHASE2 domain-containing protein	-
HGD76_RS04970	962779..963681	-	903	WP_168697370.1	hypothetical protein	-
HGD76_RS04975	963665..964249	+	585	WP_168695136.1	hypothetical protein	-
HGD76_RS04980	964410..964619	-	210	WP_168695137.1	hypothetical protein	-
HGD76_RS04985	964606..965061	-	456	WP_168695138.1	type II toxin-antitoxin system VapC family toxin	-
HGD76_RS04990	965230..965442	-	213	WP_168694531.1	hypothetical protein	-
HGD76_RS04995	965576..965953	+	378	WP_168695139.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
HGD76_RS05000	965958..966281	+	324	WP_168695140.1	helix-turn-helix domain-containing protein	Antitoxin
HGD76_RS05005	966396..967058	+	663	WP_168634612.1	response regulator transcription factor	-
HGD76_RS05010	967145..970351	-	3207	WP_168695141.1	glycoside hydrolase family 15 protein	-
HGD76_RS05020	970761..971006	-	246	WP_168695142.1	type II toxin-antitoxin system HicA family toxin	-
HGD76_RS05025	970999..971223	-	225	WP_148763256.1	type II toxin-antitoxin system HicB family antitoxin	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-like (18-110)

Antitoxin

• Cro/C1-type helix-turn-helix domain (34-89)

Sequences

Toxin

Protein

• Length: 126 a.a.
• Molecular weight: 14420.49 Da
• Isoelectric Point: 7.4633

>T153791 WP_168695139.1 NZ_CP051206:965576-965953 [Dolichospermum flos-aquae CCAP 1403/13F]
MNEKQEKPFRWIASALHDLKKFPEDVQDVMGYALDLAQHGQKHPDTKPLRGFSGAGVLEIVDDFDGDTYRAIYTVKFEGV
IYLLHSFQKKSKHGIATPKQDIELVKKRLKIAQENYLQQTTEKME

Nucleotide

• Length: 378 bp

>T153791 NZ_CP067095:c7349-6933 [Klebsiella michiganensis]
GTGAACAAGACCTATATGCTCGACACCTGTATCTGCTCGTTCATCATGCGCGAGCAGCCGGAAGCCGTCCTGAAGCGCCT
GGAGCTGGCGGTGCTGCGCGGCCAGCGCATCGTTGTCTCGGCCATCACTTATTCTGAAATGCGCTTCGGGGCCACCGGCC
CGAAGGCCTCCCCGCGCCACGTCGAGCTGGTCGACGCGTTCTGCGCCCGCCTCGATGCCATCCTGCCCTGGGATCGCGCT
GCGGTGGACGCCACCACGGAGATTAAGGTGGCGCTGCGAATGGCCGGGACGCCGATCGGCCCGAACGACACGGCCATTGC
CGGGCACGCCATCGCCGCCGGTGCCGTGCTGGTGACGAATAATACGCGGGAATTTGAGCGGGTACCGGGTCTTGTGCTGG
AAGACTGGGTAAGATAA

Antitoxin

Protein

• Length: 108 a.a.
• Molecular weight: 11930.78 Da
• Isoelectric Point: 4.8660

>AT153791 WP_168695140.1 NZ_CP051206:965958-966281 [Dolichospermum flos-aquae CCAP 1403/13F]
MPEENQVEVSNGNVFADLGLSNPEERLLKAELVRKISEIITNLNLTQVQAAEILGIDQPKVSLLIRGRLSGFSTDRLMDY
LNKLGSDVEITVKPKPENRKFAQIIVV

Nucleotide

• Length: 324 bp

>AT153791 NZ_CP067095:c7576-7346 [Klebsiella michiganensis]
ATGAGAACTGTATCCATTTTTAAAAACGGCAATAACCGCGCCATTCGTCTGCCCCGCGATCTGGATTTTGAAGGAGTGAG
CGAGCTGGAGATCGTCCGGGAAGGGGACAGCATTATTTTGCGTCCCGTCCGGCCGACCTGGGGCTCGTTCGCGCAGTTCG
AGAAGGCAGACCCGGACTTTATGGCGGAGCGCGAGGACGTTGTCAGCGACGAAGGACGATTTAACCTGTGA