Detailed information of TA system TA153788

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-VagC
• Location: 2511784..2512409
• Replicon: chromosome
• Accession: NZ_CP051203
• Organism: Treponema sp. OMZ 792

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: E4O03_RS11710
• Protein ID: WP_253685960.1
• Coordinates: 2511784..2512179 (-)
• Length: 132 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: E4O03_RS11715
• Protein ID: WP_253685962.1
• Coordinates: 2512179..2512409 (-)
• Length: 77 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
E4O03_RS11700 (E4O03_11600)	2508182..2510719	+	2538	WP_253685956.1	ribonucleoside-diphosphate reductase subunit alpha	-
E4O03_RS11705 (E4O03_11605)	2510773..2511660	-	888	WP_253685958.1	fructose bisphosphate aldolase	-
E4O03_RS11710 (E4O03_11610)	2511784..2512179	-	396	WP_253685960.1	type II toxin-antitoxin system VapC family toxin	Toxin
E4O03_RS11715 (E4O03_11615)	2512179..2512409	-	231	WP_253685962.1	type II toxin-antitoxin system VapB family antitoxin	Antitoxin
E4O03_RS11720 (E4O03_11620)	2512546..2514597	+	2052	WP_253685964.1	elongation factor G	-
E4O03_RS11725 (E4O03_11625)	2514630..2516243	-	1614	WP_253685966.1	ATP-binding cassette domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (2-123)

Antitoxin

• SpoVT-AbrB domain (7-51)

Sequences

Toxin

Protein

• Length: 132 a.a.
• Molecular weight: 15105.72 Da
• Isoelectric Point: 9.9512

>T153788 WP_253685960.1 NZ_CP051203:c2512179-2511784 [Treponema sp. OMZ 792]
MYLLDTNICIFLKNKKSPNVLQKIKENKHLGIYISSITVAELQFGVYNSKYVEKNRISLIKFLTPFSILNFDDRDAQEFG
KIRTSLKTEGKIIGAYDMLIAAQAIAKNLILVTNNTKEFCRIKNLNLEDWK

Nucleotide

• Length: 396 bp

>T153788 NZ_CP067093:5266485-5266703 [Klebsiella michiganensis]
ATGTCTGATAAAACATTAACCAAAATAGACTATTTGATGCGCTTACGACGCTGTCAGACAATTGATACGCTGGAGCGCGT
AATTGAAAAAAATAAATATGAACTTTCCGATAATGAACTGGCGGTATTTTACTCAGCGGCCGACCATCGTCTTGCTGAGC
TGACGATGAATAAACTGTATGACAAGATCCCACCTTCAGTCTGGAAATTTATCCGCTAG

Antitoxin

Protein

• Length: 77 a.a.
• Molecular weight: 8904.02 Da
• Isoelectric Point: 4.8278

>AT153788 WP_253685962.1 NZ_CP051203:c2512409-2512179 [Treponema sp. OMZ 792]
METAKLFRNGRSQAVRLPKEYNFSGTEVFIRRAGESVILFPKNKEWETFLEGLNGFTDDFMEEGRCQPDLQDRKDL

Nucleotide

• Length: 231 bp

>AT153788 NZ_CP067093:5266084-5266458 [Klebsiella michiganensis]
ATGGACGAATACTCGCCAAAAAGACATGATATTGCGCAGCTTAAATTTCTCTGCGAAACCCTGTATCATGACTGTCTTGC
AAACCTGGAAGAGAGCAACCACGGCTGGGTTAATGACCCAACTTCGGCTGTCAATCTTCAACTTAATGAATTGATCGAGC
ACATTGCCGCGTTCGCGCTTAATTATAAAATTAAGTATGCTGAGGATAATAAGCTGATTACTCAGATTGACGAATATCTG
GATGACACTTTCGTCTTGTTCAGCAACTACGGCATTAACAGTGCGGATCTGCAGAAATGGCGCAAATCTGGCAATCGGTT
ATTCCGCTGCTTTGTCAACGCCAGTCGGGAAAACCCGGCCAGTCTTTCTTGTTAG