Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 952654..953288 Replicon chromosome
Accession NZ_CP051202
Organism Treponema sp. OMZ 791

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag E4O02_RS04620 Protein ID WP_253694619.1
Coordinates 952884..953288 (+) Length 135 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag E4O02_RS04615 Protein ID WP_253694618.1
Coordinates 952654..952884 (+) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E4O02_RS04585 (E4O02_04465) 947795..948124 + 330 WP_253694588.1 hypothetical protein -
E4O02_RS04590 (E4O02_04470) 948299..948568 + 270 WP_253694614.1 BrnT family toxin -
E4O02_RS04595 (E4O02_04475) 948585..948797 + 213 WP_253694590.1 BrnA antitoxin family protein -
E4O02_RS04600 (E4O02_04480) 949121..949753 + 633 WP_253694615.1 SAP domain-containing protein -
E4O02_RS04605 (E4O02_04485) 950013..950855 + 843 WP_253694616.1 site-specific DNA-methyltransferase -
E4O02_RS04610 (E4O02_04490) 950848..951585 + 738 WP_253694617.1 PmeII family type II restriction endonuclease -
E4O02_RS04615 (E4O02_04495) 952654..952884 + 231 WP_253694618.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
E4O02_RS04620 (E4O02_04500) 952884..953288 + 405 WP_253694619.1 type II toxin-antitoxin system VapC family toxin Toxin
E4O02_RS04625 953910..954251 + 342 WP_253694620.1 hypothetical protein -
E4O02_RS04630 (E4O02_04510) 954360..954938 + 579 WP_253694621.1 prevent-host-death family protein -
E4O02_RS04635 (E4O02_04515) 955072..955317 + 246 WP_002688978.1 type II toxin-antitoxin system prevent-host-death family antitoxin -
E4O02_RS04640 (E4O02_04520) 955318..955638 + 321 WP_253694622.1 type II toxin-antitoxin system RelE/ParE family toxin -
E4O02_RS04645 (E4O02_04525) 955984..956271 + 288 WP_253694623.1 toxin -
E4O02_RS04650 (E4O02_04530) 956264..956521 + 258 WP_253694624.1 hypothetical protein -
E4O02_RS04655 (E4O02_04535) 956722..957780 + 1059 WP_253694625.1 DUF4238 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 921685..986354 64669
- inside Integron - - 952469..960800 8331


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-124)

Antitoxin

SpoVT-AbrB domain

(7-46)


Sequences

Toxin        


Download         Length: 135 a.a.        Molecular weight: 15415.79 Da        Isoelectric Point: 5.2783

>T153786 WP_253694619.1 NZ_CP051202:952884-953288 [Treponema sp. OMZ 791]
MYLLDTNICIFLIKNKNLYLKEKIFNCKKEELFLSSITIAELEYGAAKSQFREKNRQALLDFCSDFTNIIGFTTEDTETY
GMIRAYLENKGIAIGPFDTQIAAQGLARNLIVVTNNIREFSRIPGLKVEDWTKE

Download         Length: 405 bp

>T153786 NZ_CP067093:1738200-1738610 [Klebsiella michiganensis]
GTGGTCCTGTGGCAATCTGATTTACGCATCTCGTGGCGCGCGCAGTGGTTCTCACTGCTGATGCACGGCGTGGTGGCGGC
GCTGGTGCTGGTATTGCCCTGGCCGCTGAGCTATACCCCGCTGTGGCTGATATTGCTGTCGCTGGTAGTGTTCGACTGCG
TACGCAGCCAGCGGCGGATCCACGCCCGTCAGGGTGAAATAAAGCTGCTGATCGACTCGCGTCTGCGCTGGCAAAAGGCG
GAGTGGGATATCATCGGCACGCCGTGGGTAATCAACAGCGGCATGCTGCTGCGCCTGCGGAATACGGAAAACCAACGTAC
CCAGCATTTGTGGGTCGCGGCGGATAGCATGGACGCGGGAGAATGGCGCGACCTGCGTCGGCTAGTGTTACAGAAACCGA
CGCAAGAGTAG

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8731.93 Da        Isoelectric Point: 5.0658

>AT153786 WP_253694618.1 NZ_CP051202:952654-952884 [Treponema sp. OMZ 791]
MVCAKVFTSGNSQAVRIPKEFHIAFSELFIKKIGSSIILTPKESNWENLERSLSEFSDDFMTEGRSQPTMQEREVF

Download         Length: 231 bp

>AT153786 NZ_CP067093:1737953-1738219 [Klebsiella michiganensis]
ATGGACATTAACAATAAAGCCCGCATCCACTGGGCATGTCGTCGAGGTATGCGTGAACTCGATATCTCCATCATGCCGTT
TTTCGAGCATGAGTACGACACGCTAAGCGATGGCGATAAGGCGTTATTCATCCGCCTGCTGGAAAATGACGATCCGGATC
TGTTCAACTGGTTGATGAATCATGGCGAGCCGGCTGATGCTGAACTGCAGCGGATGGTAAAATTAATTCAGACTCGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References