Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PumAB/upstrm_HI1419-dnstrm_HI1420
Location 590504..591087 Replicon chromosome
Accession NZ_CP051202
Organism Treponema sp. OMZ 791

Toxin (Protein)


Gene name PumA Uniprot ID -
Locus tag E4O02_RS02730 Protein ID WP_253694149.1
Coordinates 590815..591087 (-) Length 91 a.a.

Antitoxin (Protein)


Gene name PumB Uniprot ID -
Locus tag E4O02_RS02725 Protein ID WP_253694147.1
Coordinates 590504..590818 (-) Length 105 a.a.

Genomic Context

E4O02_RS02700E4O02_RS02705E4O02_RS02710E4O02_RS02715E4O02_RS02720E4O02_RS02750E4O02_RS02725E4O02_RS02730E4O02_RS02735E4O02_RS02740E4O02_RS02745
Location: 585864..586241 (378 bp)
Type: Others
Protein ID: WP_253694137.1
Location: 586231..586872 (642 bp)
Type: Others
Protein ID: WP_253694139.1
Location: 586876..588282 (1407 bp)
Type: Others
Protein ID: WP_253694141.1
Location: 588348..589490 (1143 bp)
Type: Others
Protein ID: WP_253694143.1
Location: 589521..590468 (948 bp)
Type: Others
Protein ID: WP_253694145.1
Location: 593796..595544 (1749 bp)
Type: Others
Protein ID: WP_253694155.1
Location: 590504..590818 (315 bp)
Type: Antitoxin
Protein ID: WP_253694147.1
Location: 590815..591087 (273 bp)
Type: Toxin
Protein ID: WP_253694149.1
Location: 591177..592460 (1284 bp)
Type: Others
Protein ID: WP_253694150.1
Location: 592651..593193 (543 bp)
Type: Others
Protein ID: WP_253694152.1
Location: 593215..593658 (444 bp)
Type: Others
Protein ID: WP_253694154.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
E4O02_RS02700 (E4O02_02700)585864..586241+378WP_253694137.1polymer-forming cytoskeletal protein-
E4O02_RS02705 (E4O02_02705)586231..586872+642WP_253694139.1hypothetical protein-
E4O02_RS02710 (E4O02_02710)586876..588282+1407WP_253694141.1tRNA (N(6)-L-threonylcarbamoyladenosine(37)-C(2))- methylthiotransferase MtaB-
E4O02_RS02715 (E4O02_02715)588348..589490+1143WP_253694143.1hypothetical protein-
E4O02_RS02720 (E4O02_02720)589521..590468+948WP_253694145.1DMT family transporter-
E4O02_RS02725 (E4O02_02725)590504..590818-315WP_253694147.1putative addiction module antidote proteinAntitoxin
E4O02_RS02730 (E4O02_02730)590815..591087-273WP_253694149.1type II toxin-antitoxin system RelE/ParE family toxinToxin
E4O02_RS02735 (E4O02_02735)591177..592460-1284WP_253694150.1family 1 glycosylhydrolase-
E4O02_RS02740 (E4O02_02740)592651..593193-543WP_253694152.116S rRNA (guanine(966)-N(2))-methyltransferase RsmD-
E4O02_RS02745 (E4O02_02745)593215..593658-444WP_253694154.1hypothetical protein-
E4O02_RS02750 (E4O02_02750)593796..595544+1749WP_253694155.1energy-dependent translational throttle protein EttA-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(2-82)

Antitoxin

Uncharacterized protein HI1420

(2-93)


Sequences

Toxin        


Download         Length: 91 a.a.        Molecular weight: 10456.32 Da        Isoelectric Point: 10.3648

>T153785 WP_253694149.1 NZ_CP051202:c591087-590815 [Treponema sp. OMZ 791]
MLSKLKDEKGKAKITDRIMRLKRGNKGDHRIIDKDIYELRIHFGPGYRIYCTDKNNEIILLLIAGDKSSQLKDIKKAQQM
IKLLEQGDTK

Download         Length: 273 bp

>T153785 NZ_CP067093:c111877-111488 [Klebsiella michiganensis]
ATGCAAACCAAATCATCCCCTTTAATGCGGGCGGCATCGTCACGCCCGTCTCCAGTGGGTGTCTGGCAGACCCTGCTGGC
CTGCCTGCTGGAACACCACTATGGTCTCACGCTTAACGATACGCCGTTCAGTGATGAACTGGTCATTCAGCAGCATATCG
ACGCGGGTATCTCGCTGGCCGATGCCCTGAATTTTATTGTAGAAAAGTACGAACTGGTCCGGACTGACCGGCCAGGCTTC
AGCATCAGGGAGCAATCTCCGTTTATTACGGCGATTGATATCCTCCGGGCCAGAAAGGCTACGGGGCTGATGAACCGTGG
CACTTATAAAGAGGTGACGGCCATTACCAGAGGACTGCATCGACAGGTCAGCATTCCCGGTAAACGCTGA

Antitoxin


Download         Length: 105 a.a.        Molecular weight: 11788.33 Da        Isoelectric Point: 4.8307

>AT153785 WP_253694147.1 NZ_CP051202:c590818-590504 [Treponema sp. OMZ 791]
MKITDFDPADYLNTKEAMIEYLNEALKTSIEDNSPEHFTEALGDVTRAQGFTNVAKYTDLNREHLYRSLSKKGNPTFSTI
LKLLNFLGLEINIIDPQTAKPAYC

Download         Length: 315 bp

>AT153785 NZ_CP067093:c112260-111934 [Klebsiella michiganensis]
ATCAGCGAACCCTGGTGGGGGCTCAGGCGCAGTGTCTCCCCGTGTTTTGGTGCCCGTCTGGTACAGGAGGGAAACCGCCT
GCATTATCTGGCTGACCGGGCAAACTTTAACGGTCAGTTCTGTGATGCTGATTTGCGCCACCTTGACCAGGCTTTCCCGG
TATTGATGAAACAACTGGAGTTAATGCTCACCAGCGGTGAACTGAACCCCCGACATCAGCACCTCGTTACGCTGTATGCA
AAAGGTCTGACCTGCGAAGCCGATACGCTCGGTTCGCACGGCTACGTTTGTATCGCGATTTATCCCACTCCTGTAGCCAC
GGCATAA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
No matching records found

Antitoxin

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Source
ID
Structure
No matching records found

References