Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | vapBC/VapC-VagC |
| Location | 925708..926342 | Replicon | chromosome |
| Accession | NZ_CP051201 | ||
| Organism | Treponema sp. OMZ 790 | ||
Toxin (Protein)
| Gene name | vapC | Uniprot ID | - |
| Locus tag | E4O01_RS04380 | Protein ID | WP_253694619.1 |
| Coordinates | 925938..926342 (+) | Length | 135 a.a. |
Antitoxin (Protein)
| Gene name | vapB | Uniprot ID | - |
| Locus tag | E4O01_RS04375 | Protein ID | WP_253694618.1 |
| Coordinates | 925708..925938 (+) | Length | 77 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| E4O01_RS04345 (E4O01_04300) | 920847..921176 | + | 330 | WP_253694588.1 | hypothetical protein | - |
| E4O01_RS04350 (E4O01_04305) | 921351..921623 | + | 273 | WP_253694589.1 | BrnT family toxin | - |
| E4O01_RS04355 (E4O01_04310) | 921640..921852 | + | 213 | WP_253694590.1 | BrnA antitoxin family protein | - |
| E4O01_RS04360 (E4O01_04315) | 922176..922808 | + | 633 | WP_253694615.1 | SAP domain-containing protein | - |
| E4O01_RS04365 (E4O01_04320) | 923068..923910 | + | 843 | WP_253694616.1 | site-specific DNA-methyltransferase | - |
| E4O01_RS04370 (E4O01_04325) | 923903..924640 | + | 738 | WP_253730186.1 | PmeII family type II restriction endonuclease | - |
| E4O01_RS04375 (E4O01_04330) | 925708..925938 | + | 231 | WP_253694618.1 | type II toxin-antitoxin system VapB family antitoxin | Antitoxin |
| E4O01_RS04380 (E4O01_04335) | 925938..926342 | + | 405 | WP_253694619.1 | type II toxin-antitoxin system VapC family toxin | Toxin |
| E4O01_RS04385 (E4O01_04340) | 926660..927310 | + | 651 | WP_253679575.1 | hypothetical protein | - |
| E4O01_RS04390 (E4O01_04345) | 927419..927997 | + | 579 | WP_253694621.1 | prevent-host-death family protein | - |
| E4O01_RS04395 (E4O01_04350) | 928131..928376 | + | 246 | WP_002688978.1 | type II toxin-antitoxin system prevent-host-death family antitoxin | - |
| E4O01_RS04400 (E4O01_04355) | 928377..928697 | + | 321 | WP_253694622.1 | type II toxin-antitoxin system RelE/ParE family toxin | - |
| E4O01_RS04405 (E4O01_04360) | 929043..929330 | + | 288 | WP_253694623.1 | toxin | - |
| E4O01_RS04410 (E4O01_04365) | 929323..929580 | + | 258 | WP_253694624.1 | hypothetical protein | - |
| E4O01_RS04415 (E4O01_04370) | 929781..930839 | + | 1059 | WP_253694625.1 | DUF4238 domain-containing protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Genomic island | - | - | 848654..947056 | 98402 | |
| - | inside | Integron | - | - | 925523..933859 | 8336 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 135 a.a. Molecular weight: 15415.79 Da Isoelectric Point: 5.2783
>T153784 WP_253694619.1 NZ_CP051201:925938-926342 [Treponema sp. OMZ 790]
MYLLDTNICIFLIKNKNLYLKEKIFNCKKEELFLSSITIAELEYGAAKSQFREKNRQALLDFCSDFTNIIGFTTEDTETY
GMIRAYLENKGIAIGPFDTQIAAQGLARNLIVVTNNIREFSRIPGLKVEDWTKE
MYLLDTNICIFLIKNKNLYLKEKIFNCKKEELFLSSITIAELEYGAAKSQFREKNRQALLDFCSDFTNIIGFTTEDTETY
GMIRAYLENKGIAIGPFDTQIAAQGLARNLIVVTNNIREFSRIPGLKVEDWTKE
Download Length: 405 bp
>T153784 NZ_CP067092:c86973-86575 [Salmonella enterica subsp. enterica serovar Typhimurium]
ATGCTGAAGTTTATGCTGGATACTAACATCTGCATTTTCACGATAAAAAACAAACCTGCCAGCGTCAGGGAGCGTTTTAA
CCTGAACCAGGGGAGAATGTGTATCAGCTCGGTCACCCTGATGGAGCTGATTTACGGCGCCGAAAAAAGCCAGATGCCCG
AAAGAAATCTCGCTGTGATAGAGGGGTTTGTTTCCCGACTTGATGTTCTGGATTATGACACGCCGGCCGCCACCCATACG
GGGCAGATCAGGGCAGAGCTTGCCCGTCAGGGACGCCCTGTCGGGCCATTCGATCAGATGATTGCCGGTCACGCACGCAG
CCGGGGACTGATTGTTGTCACGAACAACACCCGGGAGTTTGAACGTGTGGGTGGACTGAGAACTGAGGACTGGAGCTGA
ATGCTGAAGTTTATGCTGGATACTAACATCTGCATTTTCACGATAAAAAACAAACCTGCCAGCGTCAGGGAGCGTTTTAA
CCTGAACCAGGGGAGAATGTGTATCAGCTCGGTCACCCTGATGGAGCTGATTTACGGCGCCGAAAAAAGCCAGATGCCCG
AAAGAAATCTCGCTGTGATAGAGGGGTTTGTTTCCCGACTTGATGTTCTGGATTATGACACGCCGGCCGCCACCCATACG
GGGCAGATCAGGGCAGAGCTTGCCCGTCAGGGACGCCCTGTCGGGCCATTCGATCAGATGATTGCCGGTCACGCACGCAG
CCGGGGACTGATTGTTGTCACGAACAACACCCGGGAGTTTGAACGTGTGGGTGGACTGAGAACTGAGGACTGGAGCTGA
Antitoxin
Download Length: 77 a.a. Molecular weight: 8731.93 Da Isoelectric Point: 5.0658
>AT153784 WP_253694618.1 NZ_CP051201:925708-925938 [Treponema sp. OMZ 790]
MVCAKVFTSGNSQAVRIPKEFHIAFSELFIKKIGSSIILTPKESNWENLERSLSEFSDDFMTEGRSQPTMQEREVF
MVCAKVFTSGNSQAVRIPKEFHIAFSELFIKKIGSSIILTPKESNWENLERSLSEFSDDFMTEGRSQPTMQEREVF
Download Length: 231 bp
>AT153784 NZ_CP067092:c87200-86973 [Salmonella enterica subsp. enterica serovar Typhimurium]
ATGGAAACCAGCGTATTTCTCAGTAACCGCAGCCAGGCGGTCAGACTGCCAAAAGCAGTGGCTTTGCCGGAAAATGTAAA
ACGTGTGGAAGTTATCGCTGTCGGGCGAACCCGAATTATCACGCCGGCCGGAGAATCGTGGGATGAATGGTTCGACGGGA
ACAACGTCAGCGCCGATTTTATGGATAACCGGGAACAACCCTCTGTGCAGGAACGGGAATCATTCTGA
ATGGAAACCAGCGTATTTCTCAGTAACCGCAGCCAGGCGGTCAGACTGCCAAAAGCAGTGGCTTTGCCGGAAAATGTAAA
ACGTGTGGAAGTTATCGCTGTCGGGCGAACCCGAATTATCACGCCGGCCGGAGAATCGTGGGATGAATGGTTCGACGGGA
ACAACGTCAGCGCCGATTTTATGGATAACCGGGAACAACCCTCTGTGCAGGAACGGGAATCATTCTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|
Antitoxin
| Source | ID | Structure |
|---|