153783

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PumAB/upstrm_HI1419-dnstrm_HI1420
Location 590578..591161 Replicon chromosome
Accession NZ_CP051201
Organism Treponema sp. OMZ 790

Toxin (Protein)


Gene name PumA Uniprot ID -
Locus tag E4O01_RS02735 Protein ID WP_253694149.1
Coordinates 590889..591161 (-) Length 91 a.a.

Antitoxin (Protein)


Gene name PumB Uniprot ID -
Locus tag E4O01_RS02730 Protein ID WP_253694147.1
Coordinates 590578..590892 (-) Length 105 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E4O01_RS02705 (E4O01_02700) 585938..586315 + 378 WP_253694137.1 polymer-forming cytoskeletal protein -
E4O01_RS02710 (E4O01_02705) 586305..586946 + 642 WP_253694139.1 hypothetical protein -
E4O01_RS02715 (E4O01_02710) 586950..588356 + 1407 WP_253694141.1 tRNA (N(6)-L-threonylcarbamoyladenosine(37)-C(2))- methylthiotransferase MtaB -
E4O01_RS02720 (E4O01_02715) 588422..589564 + 1143 WP_253694143.1 hypothetical protein -
E4O01_RS02725 (E4O01_02720) 589595..590542 + 948 WP_253694145.1 DMT family transporter -
E4O01_RS02730 (E4O01_02725) 590578..590892 - 315 WP_253694147.1 putative addiction module antidote protein Antitoxin
E4O01_RS02735 (E4O01_02730) 590889..591161 - 273 WP_253694149.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
E4O01_RS02740 (E4O01_02735) 591251..592534 - 1284 WP_253694150.1 family 1 glycosylhydrolase -
E4O01_RS02745 (E4O01_02740) 592725..593267 - 543 WP_253694152.1 16S rRNA (guanine(966)-N(2))-methyltransferase RsmD -
E4O01_RS02750 (E4O01_02745) 593289..593732 - 444 WP_253694154.1 hypothetical protein -
E4O01_RS02755 (E4O01_02750) 593870..595618 + 1749 WP_253694155.1 energy-dependent translational throttle protein EttA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(2-82)

Antitoxin

Uncharacterized protein HI1420

(2-93)


Sequences

Toxin        


Download         Length: 91 a.a.        Molecular weight: 10456.32 Da        Isoelectric Point: 10.3648

>T153783 WP_253694149.1 NZ_CP051201:c591161-590889 [Treponema sp. OMZ 790]
MLSKLKDEKGKAKITDRIMRLKRGNKGDHRIIDKDIYELRIHFGPGYRIYCTDKNNEIILLLIAGDKSSQLKDIKKAQQM
IKLLEQGDTK

Download         Length: 273 bp

>T153783 NZ_CP067092:20316-20621 [Salmonella enterica subsp. enterica serovar Typhimurium]
ATGCAGTTTAAGGTTTACACCTGTAAAAGGGAGAGTCGCTACCGGCTGTTTGTGGACGTGCAGAGCGACATCATTGACAC
CCCCGGACGGCGGATGGCTGTCCCGCTGGTCAGCGCCCGTCTGCTGTCGGAAAAGGTTCCCCGCGATCTTTACCCGGTGA
TGCATATCGGGGATGAGCCTTACCGCCTGCTGACCACGGATATGACCAGTGTGCCGGCCACCGTCATCGGGGAAGAGGTG
GCCGATCTCAGCCTCCGGGAGAACGATATCAAAAACGCCATTAACCTGATGTTCCGGGGGATCTGA

Antitoxin


Download         Length: 105 a.a.        Molecular weight: 11788.33 Da        Isoelectric Point: 4.8307

>AT153783 WP_253694147.1 NZ_CP051201:c590892-590578 [Treponema sp. OMZ 790]
MKITDFDPADYLNTKEAMIEYLNEALKTSIEDNSPEHFTEALGDVTRAQGFTNVAKYTDLNREHLYRSLSKKGNPTFSTI
LKLLNFLGLEINIIDPQTAKPAYC

Download         Length: 315 bp

>AT153783 NZ_CP067092:20096-20314 [Salmonella enterica subsp. enterica serovar Typhimurium]
ATGAAGCAGCGAATTACAGTGACAGTGGACAGCGACAGCTATCAGCTGCTCAAGGCATACGACGTGAATATCTCCGGTCT
GGTCAGTACGACCATGCAGAACGAAGCCCGCCGTCTGCGAGCCGAACGCTGGCAGGAAGAAAATCGGGAAGGTATGGCTG
AGGTGGCCAGCTTTATAGAGGCTAACGGATCGTTTGCTGACGACAACAGGAACTGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References