Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 925806..926440 Replicon chromosome
Accession NZ_CP051200
Organism Treponema sp. OMZ 789

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag E4O06_RS04355 Protein ID WP_253694619.1
Coordinates 926036..926440 (+) Length 135 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag E4O06_RS04350 Protein ID WP_253694618.1
Coordinates 925806..926036 (+) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E4O06_RS04315 (E4O06_04310) 920944..921273 + 330 WP_253694588.1 hypothetical protein -
E4O06_RS04320 (E4O06_04315) 921448..921720 + 273 WP_253694589.1 BrnT family toxin -
E4O06_RS04325 (E4O06_04320) 921737..921949 + 213 WP_253694590.1 BrnA antitoxin family protein -
E4O06_RS04330 922079..922180 + 102 WP_253719335.1 DUF3781 domain-containing protein -
E4O06_RS04335 (E4O06_04325) 922273..922905 + 633 WP_253694615.1 SAP domain-containing protein -
E4O06_RS04340 (E4O06_04330) 923165..924007 + 843 WP_253694616.1 site-specific DNA-methyltransferase -
E4O06_RS04345 (E4O06_04335) 924000..924737 + 738 WP_253694617.1 PmeII family type II restriction endonuclease -
E4O06_RS04350 (E4O06_04340) 925806..926036 + 231 WP_253694618.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
E4O06_RS04355 (E4O06_04345) 926036..926440 + 405 WP_253694619.1 type II toxin-antitoxin system VapC family toxin Toxin
E4O06_RS04360 (E4O06_04350) 926758..927408 + 651 WP_253679575.1 hypothetical protein -
E4O06_RS04365 (E4O06_04355) 927517..928095 + 579 WP_253694621.1 prevent-host-death family protein -
E4O06_RS04370 (E4O06_04360) 928229..928474 + 246 WP_002688978.1 type II toxin-antitoxin system prevent-host-death family antitoxin -
E4O06_RS04375 (E4O06_04365) 928475..928795 + 321 WP_253694622.1 type II toxin-antitoxin system RelE/ParE family toxin -
E4O06_RS04380 (E4O06_04370) 929141..929428 + 288 WP_253694623.1 toxin -
E4O06_RS04385 (E4O06_04375) 929421..929678 + 258 WP_253694624.1 hypothetical protein -
E4O06_RS04390 (E4O06_04380) 929879..930937 + 1059 WP_253694625.1 DUF4238 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 894813..947154 52341
- inside Integron - - 925621..933957 8336


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-124)

Antitoxin

SpoVT-AbrB domain

(7-46)


Sequences

Toxin        


Download         Length: 135 a.a.        Molecular weight: 15415.79 Da        Isoelectric Point: 5.2783

>T153782 WP_253694619.1 NZ_CP051200:926036-926440 [Treponema sp. OMZ 789]
MYLLDTNICIFLIKNKNLYLKEKIFNCKKEELFLSSITIAELEYGAAKSQFREKNRQALLDFCSDFTNIIGFTTEDTETY
GMIRAYLENKGIAIGPFDTQIAAQGLARNLIVVTNNIREFSRIPGLKVEDWTKE

Download         Length: 405 bp

>T153782 NZ_CP067091:4724572-4724859 [Salmonella enterica subsp. enterica serovar Typhimurium]
ATGCCGATGGAGTTTGAATGGGATGCGAACAAGGCTAAAAGCAACCTGAGGAAGCACGGTGTCCGTTTTGAGGATGCGGT
ACTGGTGTTTGACGATCCCCGACACCTGTCACGTCAGGAGCGTTATGAGAATGGAGAATATCGTTGGCAGACCCTCGGCC
TTGTTCATGGCATTGTGGTCATTCTGGTTGCTCATAGCGTTCGGTTCGAAAGTGGTTTTGAAGTTATCCGTATCATCAGC
GCCCGCAAGGCAGACAGAAAAGAGAGGAATCGTTATGAGCATGGTTAA

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8731.93 Da        Isoelectric Point: 5.0658

>AT153782 WP_253694618.1 NZ_CP051200:925806-926036 [Treponema sp. OMZ 789]
MVCAKVFTSGNSQAVRIPKEFHIAFSELFIKKIGSSIILTPKESNWENLERSLSEFSDDFMTEGRSQPTMQEREVF

Download         Length: 231 bp

>AT153782 NZ_CP067091:4724846-4725148 [Salmonella enterica subsp. enterica serovar Typhimurium]
ATGAGCATGGTTAAACATAAACGCGGCAACGCATCCGCGCTGAGTGCTCAGCATGAGGCTGAACTGAAGGCGCTGGCGAA
AAAATCAGATGATGAGATTGATTACAGCGACATTCCCGCTTCGGAGGATGGGCAGTGGTCTGAAGCAGTGCGTGGTAAGT
TTTTTCGCCCGTTAAAAACTCAGGCCTCGGTGCGTATTGACGCCGATGTGATGGAGTGGCTGAAACGGCCAGGAAAAGGC
TACCAGACGCGGCTCAATGCCATTCTGCGCGAGGCGATGCTGCGCGAGCAAAATAAGAAATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References