Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PumAB/upstrm_HI1419-dnstrm_HI1420
Location 590594..591177 Replicon chromosome
Accession NZ_CP051200
Organism Treponema sp. OMZ 789

Toxin (Protein)


Gene name PumA Uniprot ID -
Locus tag E4O06_RS02740 Protein ID WP_253694149.1
Coordinates 590905..591177 (-) Length 91 a.a.

Antitoxin (Protein)


Gene name PumB Uniprot ID -
Locus tag E4O06_RS02735 Protein ID WP_253694147.1
Coordinates 590594..590908 (-) Length 105 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E4O06_RS02710 (E4O06_02710) 585954..586331 + 378 WP_253694137.1 polymer-forming cytoskeletal protein -
E4O06_RS02715 (E4O06_02715) 586321..586962 + 642 WP_253694139.1 hypothetical protein -
E4O06_RS02720 (E4O06_02720) 586966..588372 + 1407 WP_253694141.1 tRNA (N(6)-L-threonylcarbamoyladenosine(37)-C(2))- methylthiotransferase MtaB -
E4O06_RS02725 (E4O06_02725) 588438..589580 + 1143 WP_253694143.1 hypothetical protein -
E4O06_RS02730 (E4O06_02730) 589611..590558 + 948 WP_253694145.1 DMT family transporter -
E4O06_RS02735 (E4O06_02735) 590594..590908 - 315 WP_253694147.1 putative addiction module antidote protein Antitoxin
E4O06_RS02740 (E4O06_02740) 590905..591177 - 273 WP_253694149.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
E4O06_RS02745 (E4O06_02745) 591267..592550 - 1284 WP_253694150.1 family 1 glycosylhydrolase -
E4O06_RS02750 (E4O06_02750) 592741..593283 - 543 WP_253694152.1 16S rRNA (guanine(966)-N(2))-methyltransferase RsmD -
E4O06_RS02755 (E4O06_02755) 593305..593748 - 444 WP_253694154.1 hypothetical protein -
E4O06_RS02760 (E4O06_02760) 593886..595634 + 1749 WP_253694155.1 energy-dependent translational throttle protein EttA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(2-82)

Antitoxin

Uncharacterized protein HI1420

(2-93)


Sequences

Toxin        


Download         Length: 91 a.a.        Molecular weight: 10456.32 Da        Isoelectric Point: 10.3648

>T153781 WP_253694149.1 NZ_CP051200:c591177-590905 [Treponema sp. OMZ 789]
MLSKLKDEKGKAKITDRIMRLKRGNKGDHRIIDKDIYELRIHFGPGYRIYCTDKNNEIILLLIAGDKSSQLKDIKKAQQM
IKLLEQGDTK

Download         Length: 273 bp

>T153781 NZ_CP067091:4629728-4630012 [Salmonella enterica subsp. enterica serovar Typhimurium]
ATGACTTATGAACTGGAATTCGACCCGAGGGCCTTAAAAGAGTGGCATAAGCTGGGCGATACGGTGAAGGCTCAGCTTAA
GAAAAAGTTGGCTGATGTGCTATTGAACCCCAGAATCGACTCTGCCCGTTTAAACGGTCTTCCTGACTGCTATAAAATTA
AGCTTAAATCGTCCGGTTATCGTCTGGTGTACCAGGTTCGGGATGACGTTGTGATTGTGTTTGTTGTTGCGGTCGGCAAG
CGAGAACATTCAGCCGTCTATCACGATACAAACAAACGGCTTTAG

Antitoxin


Download         Length: 105 a.a.        Molecular weight: 11788.33 Da        Isoelectric Point: 4.8307

>AT153781 WP_253694147.1 NZ_CP051200:c590908-590594 [Treponema sp. OMZ 789]
MKITDFDPADYLNTKEAMIEYLNEALKTSIEDNSPEHFTEALGDVTRAQGFTNVAKYTDLNREHLYRSLSKKGNPTFSTI
LKLLNFLGLEINIIDPQTAKPAYC

Download         Length: 315 bp

>AT153781 NZ_CP067091:4629496-4629738 [Salmonella enterica subsp. enterica serovar Typhimurium]
ATGGCCACGCTGAACGTCCGTCTGGATGACAAACTCAAAAATGAGGCTTATGCCGTGCTGGAAAAACTGAACATTACTCC
AACGGAAGCCGTGCGATTACTGTTCCAGTACGTCGCGGAAACGGGGCGCATGCCAGTGAAAACCGTCACTCTTAGCGACA
GTGAAGATGCATTGATTCAGACAGTTCGGGAGAGGCTGTCTAGTCCGCAAAAGGGAATCAAGGTTAGTCTGGATGACTTA
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References