Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PRK09907-MazE
Location 2686311..2686807 Replicon chromosome
Accession NZ_CP051199
Organism Treponema sp. OMZ 788

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag E4O00_RS13305 Protein ID WP_253677829.1
Coordinates 2686311..2686580 (-) Length 90 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag E4O00_RS13310 Protein ID WP_253677830.1
Coordinates 2686574..2686807 (-) Length 78 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E4O00_RS13290 (E4O00_12545) 2682687..2683496 - 810 WP_253677826.1 DNA repair protein RecO C-terminal domain-containing protein -
E4O00_RS13295 (E4O00_12550) 2683499..2684998 - 1500 WP_253677827.1 HEAT repeat domain-containing protein -
E4O00_RS13300 (E4O00_12555) 2685069..2686202 - 1134 WP_253677828.1 tRNA guanosine(34) transglycosylase Tgt -
E4O00_RS13305 (E4O00_12560) 2686311..2686580 - 270 WP_253677829.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
E4O00_RS13310 (E4O00_12565) 2686574..2686807 - 234 WP_253677830.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
E4O00_RS13315 (E4O00_12570) 2687078..2687803 + 726 WP_253677831.1 gamma-glutamyl-gamma-aminobutyrate hydrolase family protein -
E4O00_RS13320 (E4O00_12575) 2687862..2689411 + 1550 Protein_2619 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(6-85)

Antitoxin

Antitoxin PemI-like

(1-77)


Sequences

Toxin        


Download         Length: 90 a.a.        Molecular weight: 10118.73 Da        Isoelectric Point: 9.5004

>T153780 WP_253677829.1 NZ_CP051199:c2686580-2686311 [Treponema sp. OMZ 788]
MVNSNYVPDKGDLVWLDFNPQAGHEQKGRRPAICISQKRYNQKVGLALFCPITSHIKGYPFEIVLDNPSINGCILSDQVK
NLDYKKKKL

Download         Length: 270 bp

>T153780 NZ_CP051199:c2686580-2686311 [Treponema sp. OMZ 788]
ATGGTAAATTCAAATTATGTTCCCGATAAAGGCGATTTAGTTTGGCTTGATTTTAATCCGCAAGCAGGACATGAGCAGAA
AGGCCGTCGTCCTGCAATTTGCATTTCTCAAAAAAGATATAATCAAAAAGTTGGACTTGCTTTATTTTGTCCTATTACAA
GCCATATAAAAGGCTATCCTTTTGAAATTGTATTGGATAATCCTTCGATAAATGGCTGTATTCTTAGCGACCAAGTAAAG
AACCTTGATTATAAAAAAAAGAAGCTGTGA

Antitoxin


Download         Length: 78 a.a.        Molecular weight: 8693.97 Da        Isoelectric Point: 5.7928

>AT153780 WP_253677830.1 NZ_CP051199:c2686807-2686574 [Treponema sp. OMZ 788]
MQVVVQKWGNSLGFRIPSLWAKDNNVKNGSKIEVIAEKGKMVILPQKKTLDDMLEMVTSENVHSEISTSYSVGNEEW

Download         Length: 234 bp

>AT153780 NZ_CP051199:c2686807-2686574 [Treponema sp. OMZ 788]
ATGCAGGTTGTAGTTCAGAAATGGGGTAACAGCCTCGGATTTAGAATTCCGTCTCTTTGGGCAAAAGATAATAATGTAAA
GAATGGAAGCAAAATAGAAGTAATAGCAGAAAAAGGAAAAATGGTAATTCTTCCCCAGAAAAAAACTCTTGATGATATGC
TGGAAATGGTTACTTCTGAAAATGTTCATTCAGAAATATCGACAAGTTATTCAGTAGGTAACGAAGAATGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References