Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1-VagC
Location 2635652..2636277 Replicon chromosome
Accession NZ_CP051199
Organism Treponema sp. OMZ 788

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag E4O00_RS13100 Protein ID WP_253677792.1
Coordinates 2635652..2636047 (-) Length 132 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag E4O00_RS13105 Protein ID WP_253677793.1
Coordinates 2636047..2636277 (-) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E4O00_RS13090 (E4O00_12360) 2632052..2634589 + 2538 WP_253677790.1 ribonucleoside-diphosphate reductase subunit alpha -
E4O00_RS13095 (E4O00_12365) 2634640..2635527 - 888 WP_253677791.1 fructose bisphosphate aldolase -
E4O00_RS13100 (E4O00_12370) 2635652..2636047 - 396 WP_253677792.1 type II toxin-antitoxin system VapC family toxin Toxin
E4O00_RS13105 (E4O00_12375) 2636047..2636277 - 231 WP_253677793.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
E4O00_RS13110 (E4O00_12380) 2636486..2637385 + 900 WP_253677794.1 hypothetical protein -
E4O00_RS13115 (E4O00_12385) 2637468..2639519 + 2052 WP_253677795.1 elongation factor G -
E4O00_RS13120 (E4O00_12390) 2639498..2640187 - 690 WP_253677796.1 DUF4299 family protein -
E4O00_RS13125 (E4O00_12395) 2640367..2641035 + 669 WP_253677797.1 response regulator transcription factor -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-123)

Antitoxin

SpoVT-AbrB domain

(7-51)


Sequences

Toxin        


Download         Length: 132 a.a.        Molecular weight: 15163.76 Da        Isoelectric Point: 9.7947

>T153779 WP_253677792.1 NZ_CP051199:c2636047-2635652 [Treponema sp. OMZ 788]
MYLLDTNICIFLKNKKSPNVLQKIKENKHLGIYISSITVAELQFGVYNSKYVEKNRISLIKFLTPFSILNFDDRDAQEFG
KIRTSLKTEGKIIDAYDMLIAAQAIAKNLILVTNNTKEFCRIKNLNLEDWK

Download         Length: 396 bp

>T153779 NZ_CP067091:4179690-4180001 [Salmonella enterica subsp. enterica serovar Typhimurium]
ATGCAATTTATAGAAACGGAACTCTTTACTGAAGATGTTAAAAAACTGCTCGATGATGATGAATACCATAAGCTTCAGGT
TTTTATGGCTCAGCATCCAGATTGTGGTGATGTCATTCAGGAAACGGGCGGCCTGAGAAAAATGCGCTGGGGAGCGCGAG
GCAAAGGAAAGCGTAGTGGCGTGCGAATTATCTATTTTCACCGTAGTCAACGGTATGAGATTCGCTTGCTTCTGATTTAT
CAAAAAGGCATTAAAGATGATCTCACGCCGCAGGAAAAAGCGGTGCTTCGTATGCTGAATGAGAGGTGGTAG

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8874.04 Da        Isoelectric Point: 5.1229

>AT153779 WP_253677793.1 NZ_CP051199:c2636277-2636047 [Treponema sp. OMZ 788]
METAKLFRNGRSQAVRLPKEYNFSGTEVFIRRAGESVILFPKNKEWETFLEGLNGFTDDFMVEGRCQPDLQDRKDL

Download         Length: 231 bp

>AT153779 NZ_CP067091:4180002-4180292 [Salmonella enterica subsp. enterica serovar Typhimurium]
ATGGATAAAGTGTTATTTGAGCGATTAACTCAAAGTATGTCTCAAATGAATGAAATCATTGAAGGGACCCGTGAACCTTC
TCGTACCTTTCATATTGATGCAATGAAGATTAAAGAAATACGGCAGGCATCTGGGTTGTCGCAATCTAAGTTTGCAGAGC
TGATTTCGGTCAACGTGGATACGCTGCGCAACTGGGAGCAAGGAAGACGTTCACCGACAGGGCCAGCCAAAGCGTTACTT
CGCGCCATTGCCAACGACCCGAGAAACGTTATACAAGCATTGCGTTATTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References