Detailed information of TA system TA153778

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): BrnTA/BrnT-BrnA
• Location: 1553022..1553577
• Replicon: chromosome
• Accession: NZ_CP051199
• Organism: Treponema sp. OMZ 788

Toxin (Protein)

• Gene name: brnT
• Uniprot ID: -
• Locus tag: E4O00_RS07600
• Protein ID: WP_253676776.1
• Coordinates: 1553275..1553577 (-)
• Length: 101 a.a.

Antitoxin (Protein)

• Gene name: brnA
• Uniprot ID: -
• Locus tag: E4O00_RS07595
• Protein ID: WP_253679674.1
• Coordinates: 1553022..1553294 (-)
• Length: 91 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
E4O00_RS07580 (E4O00_07245)	1548404..1549468	-	1065	WP_253676767.1	FliG C-terminal domain-containing protein	-
E4O00_RS07585 (E4O00_07250)	1549549..1551612	-	2064	WP_253676769.1	methyl-accepting chemotaxis protein	-
E4O00_RS07590 (E4O00_07255)	1551680..1552993	-	1314	WP_253676771.1	extracellular solute-binding protein	-
E4O00_RS07595 (E4O00_07260)	1553022..1553294	-	273	WP_253679674.1	BrnA antitoxin family protein	Antitoxin
E4O00_RS07600 (E4O00_07265)	1553275..1553577	-	303	WP_253676776.1	BrnT family toxin	Toxin
E4O00_RS07605 (E4O00_07270)	1553664..1554366	+	703	Protein_1492	DNA alkylation repair protein	-
E4O00_RS07610 (E4O00_07275)	1554363..1556759	-	2397	WP_253676777.1	VWA domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Ribonuclease toxin, BrnT, of type II toxin-antitoxin system (8-86)

Antitoxin

• BrnA antitoxin of type II toxin-antitoxin system (42-81)

Sequences

Toxin

Protein

• Length: 101 a.a.
• Molecular weight: 11586.00 Da
• Isoelectric Point: 4.8997

>T153778 WP_253676776.1 NZ_CP051199:c1553577-1553275 [Treponema sp. OMZ 788]
MVRDCFEWDTTKNDNNKRKHGVSFEDAILIFDDPYLLEKYDSKHSEYEDRFLAIGSICGLVLIAVAYTDRAGITRIISAR
SATKAEKELYYDKINEYYGS

Nucleotide

• Length: 303 bp

>T153778 NZ_CP067091:c4178457-4178146 [Salmonella enterica subsp. enterica serovar Typhimurium]
GTGCATGTTATCAGCCGAAAACCGTTCAATGAAGCGATGCTCATGTATCCAAACCATGAGCTTGCTCTCACTGAGTTGCT
GAATGTTCTGGAGAAAAAAACATTCACTCAGCCTGAAGAGATGAAGCGGTATATTCCTTCACTGGATAATTTTAAGTACA
GAGATAAATGGTGGGTGATTGATGTTTCTGGTAACAGCCTGAGACTCATTTCCTACATAGATTTCAGGTTACATAAGATA
TTTGTGAAACATATCGTTTCCCATGCCGAATATGACAAACTGACCGCATACTATCGGGGTAATAAAGAATGA

Antitoxin

Protein

• Length: 91 a.a.
• Molecular weight: 10428.11 Da
• Isoelectric Point: 10.0035

>AT153778 WP_253679674.1 NZ_CP051199:c1553294-1553022 [Treponema sp. OMZ 788]
MNITEAKKNLTKEKIEELKALNDRPIDTSDIPELTKADFLEMYRPVKKPLSIRLDSDIIAWLKSYGKGYQSRINTILRQA
MNTDKKANVF

Nucleotide

• Length: 273 bp

>AT153778 NZ_CP067091:c4178149-4177703 [Salmonella enterica subsp. enterica serovar Typhimurium]
ATGAGAACTCATCGTCAGATGGATGCAACCAGCGCAAAAAAGATCGTTGATACCTTCAGCGATGCGGTAAAAACCGTCCC
ACTGATGGGGGAAGACCGAAATGACAATGAGTATCGCAGGGCACTAGCGCTAGTGGAGTTTCTGGTCGACCACGACGATC
TTGAAAACCCACTATTTGAATTGCTCTGTGCCCGAATCAGTGAATACGAAAAACATGCGCCGGAATTCAAAGCACTCAAC
CAACACCTGGAGAAAACGCCCCCTGGCGTTTCAGTATTGCGAACGCTCATGGATCAATACGGTCTCAAAGCAGCAGATCT
TGCCAACGAACTTGGTTCTAAATCGAACGTCAGCAACATCTTAAATGGCCGCAGAGCACTAACGGTTAATCATATTAAAG
CGCTTACACAACGCTTCAAACTACCAGCAGATGCCTTCATCGAGTAG