Detailed information of TA system TA153776

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): chpIK/PemK(toxin)
• Location: 240159..240726
• Replicon: chromosome
• Accession: NZ_CP051199
• Organism: Treponema sp. OMZ 788

Toxin (Protein)

• Gene name: chpK
• Uniprot ID: -
• Locus tag: E4O00_RS01050
• Protein ID: WP_253678142.1
• Coordinates: 240159..240500 (-)
• Length: 114 a.a.

Antitoxin (Protein)

• Gene name: chpI
• Uniprot ID: -
• Locus tag: E4O00_RS01055
• Protein ID: WP_253678143.1
• Coordinates: 240487..240726 (-)
• Length: 80 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
E4O00_RS01040 (E4O00_00995)	236750..238408	+	1659	WP_253678140.1	ABC transporter ATP-binding protein	-
E4O00_RS01045 (E4O00_01000)	238489..240108	+	1620	WP_253678141.1	ATP-binding protein	-
E4O00_RS01050 (E4O00_01005)	240159..240500	-	342	WP_253678142.1	type II toxin-antitoxin system PemK/MazF family toxin	Toxin
E4O00_RS01055 (E4O00_01010)	240487..240726	-	240	WP_253678143.1	hypothetical protein	Antitoxin
E4O00_RS01060 (E4O00_01015)	240879..241715	-	837	WP_253678144.1	hypothetical protein	-
E4O00_RS01065 (E4O00_01020)	241961..242800	+	840	WP_253678145.1	Rpn family recombination-promoting nuclease/putative transposase	-
E4O00_RS01070 (E4O00_01025)	242843..243466	-	624	WP_253678146.1	precorrin-8X methylmutase	-
E4O00_RS01075 (E4O00_01030)	243456..244385	-	930	WP_253678147.1	Hsp33 family molecular chaperone HslO	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• mRNA interferase PemK-like (2-111)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 114 a.a.
• Molecular weight: 12648.92 Da
• Isoelectric Point: 10.0501

>T153776 WP_253678142.1 NZ_CP051199:c240500-240159 [Treponema sp. OMZ 788]
MMRGELWFADLGIPFGSETGYRRPVIIMQNDLFNVSKIRTIEVVPLTTNLILGEAPGNVIINKKNSKLPKDSVAVVSQLT
AIDKTRFIEKIGKINKNLIKEIESGIRLVLDIE

Nucleotide

• Length: 342 bp

>T153776 NZ_CP067091:c3666356-3665988 [Salmonella enterica subsp. enterica serovar Typhimurium]
ATGACCCTACAACTTATCTCAGCGGAAGAGATAATTCAGTTTCACGACAGGCTTCTCCGCGTTACGCCTGGTGTAACAGG
CATGCCTGATCCTGGCCGCGCGGAAGCGCTAATGTACCGGGTACTCAAGCAAATCGAATATGAAGGGGTGACCGACGTGT
GGCTGCTGGCGGCAATGCATTTGCTCGCTATATCCCGTGGGCATATCTTCAATGATGGTAACAAACGTACCGCCTTATTT
ATTACGCTGCTGTTTTTAAAGCGTAACGGGATCTCACTCGCTGCGAATCCGGATTTTGTCGATATGACAGTCGATGCGGC
GGCAGGGCGGCTTACGCTGGAGCAAATTGCCGTTCGCTTACGTGCCTGA

Antitoxin

Protein

• Length: 80 a.a.
• Molecular weight: 9117.22 Da
• Isoelectric Point: 4.4230

>AT153776 WP_253678143.1 NZ_CP051199:c240726-240487 [Treponema sp. OMZ 788]
MKTAVSISDSLFLRAQKFQTNCNISRSKLYSDALDEYLSKREKQDITAQLNSVYEQIETEDELDIGLLALRELTKNDAW

Nucleotide

• Length: 240 bp

>AT153776 NZ_CP067091:c3666574-3666353 [Salmonella enterica subsp. enterica serovar Typhimurium]
ATGCGTACGGTTAACTATAGCGAAGCGCGGCAAAATCTGGCCGAAGTCCTGGAAAGTGCGGTGACGGGGGGGCCTGTTAC
CATCACGCGTCGTGGGCATAAGTCCGCAGTGATCATCAGCGCCGAGGAGTTTGAGCGTTATCAGACGGCGCGAATGGATG
ATGAGTTTGCTGCCATTATGGCGGTTCATGGCAATGAGCTCAGGGAGCTGGCGGATAAATGA