Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | BrnTA/BrnT-BrnA |
| Location | 1306976..1307531 | Replicon | chromosome |
| Accession | NZ_CP051198 | ||
| Organism | Treponema sp. OMZ 787 | ||
Toxin (Protein)
| Gene name | brnT | Uniprot ID | - |
| Locus tag | E4O05_RS06230 | Protein ID | WP_253676776.1 |
| Coordinates | 1306976..1307278 (+) | Length | 101 a.a. |
Antitoxin (Protein)
| Gene name | brnA | Uniprot ID | - |
| Locus tag | E4O05_RS06235 | Protein ID | WP_253679674.1 |
| Coordinates | 1307259..1307531 (+) | Length | 91 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| E4O05_RS06185 (E4O05_06140) | 1302135..1302419 | - | 285 | WP_253723750.1 | zinc ribbon domain-containing protein | - |
| E4O05_RS06190 (E4O05_06145) | 1302431..1303039 | - | 609 | WP_253723751.1 | hypothetical protein | - |
| E4O05_RS06195 (E4O05_06150) | 1303140..1303472 | - | 333 | WP_253723752.1 | hypothetical protein | - |
| E4O05_RS06200 (E4O05_06155) | 1303500..1304252 | - | 753 | WP_253723753.1 | leucine-rich repeat domain-containing protein | - |
| E4O05_RS06205 (E4O05_06160) | 1304690..1305088 | - | 399 | WP_010696932.1 | type II toxin-antitoxin system HicB family antitoxin | - |
| E4O05_RS06210 (E4O05_06165) | 1305091..1305273 | - | 183 | WP_253678786.1 | type II toxin-antitoxin system HicA family toxin | - |
| E4O05_RS06215 (E4O05_06170) | 1305405..1305596 | - | 192 | WP_253723754.1 | hypothetical protein | - |
| E4O05_RS06220 (E4O05_06175) | 1305747..1306139 | + | 393 | WP_253723755.1 | type II toxin-antitoxin system HicB family antitoxin | - |
| E4O05_RS06225 (E4O05_06180) | 1306185..1306889 | - | 705 | WP_253723756.1 | DNA alkylation repair protein | - |
| E4O05_RS06230 (E4O05_06185) | 1306976..1307278 | + | 303 | WP_253676776.1 | BrnT family toxin | Toxin |
| E4O05_RS06235 (E4O05_06190) | 1307259..1307531 | + | 273 | WP_253679674.1 | BrnA antitoxin family protein | Antitoxin |
| E4O05_RS06240 (E4O05_06195) | 1307560..1308873 | + | 1314 | WP_253723757.1 | extracellular solute-binding protein | - |
| E4O05_RS06245 (E4O05_06200) | 1308879..1311002 | + | 2124 | WP_253723758.1 | methyl-accepting chemotaxis protein | - |
| E4O05_RS06250 (E4O05_06205) | 1311083..1312147 | + | 1065 | WP_253676767.1 | FliG C-terminal domain-containing protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 101 a.a. Molecular weight: 11586.00 Da Isoelectric Point: 4.8997
>T153774 WP_253676776.1 NZ_CP051198:1306976-1307278 [Treponema sp. OMZ 787]
MVRDCFEWDTTKNDNNKRKHGVSFEDAILIFDDPYLLEKYDSKHSEYEDRFLAIGSICGLVLIAVAYTDRAGITRIISAR
SATKAEKELYYDKINEYYGS
MVRDCFEWDTTKNDNNKRKHGVSFEDAILIFDDPYLLEKYDSKHSEYEDRFLAIGSICGLVLIAVAYTDRAGITRIISAR
SATKAEKELYYDKINEYYGS
Download Length: 303 bp
>T153774 NZ_CP067091:c3144471-3144058 [Salmonella enterica subsp. enterica serovar Typhimurium]
GTGGTCCTGTGGCAATCTGATTTACGCGTCTCATGGCGCGCTCAGTGGATCTCATTGCTCATTCATGGGCTGGTTGCCGC
GGTGATTTTATTGATGCCCTGGCCGCTGAGTTATACCCCGTTATGGATGATACTACTGTCGCTGGTCGTGTTTGACTGTG
TACGTAGCCAGCGCAGGATTAATACCTGCCAGGGAGAGATCAAGCTACTCATGGACGGGCGCTTACGCTGGCAGGGGCAG
GACTGGACGCTCTTGCGTCCGCCCTGGTTACTGAAGAGCGGGATGGTGTTGCGTTTACGCGCAGAGTCTGGACGTCATCA
GCATTTATGGCTGGCGGCGGATAGCATGGAAGAAGCGGAATGGCGTGAGTTGCGTCGGATACTGTTACAGCAGCCGATAT
CAGGCCAACACTAA
GTGGTCCTGTGGCAATCTGATTTACGCGTCTCATGGCGCGCTCAGTGGATCTCATTGCTCATTCATGGGCTGGTTGCCGC
GGTGATTTTATTGATGCCCTGGCCGCTGAGTTATACCCCGTTATGGATGATACTACTGTCGCTGGTCGTGTTTGACTGTG
TACGTAGCCAGCGCAGGATTAATACCTGCCAGGGAGAGATCAAGCTACTCATGGACGGGCGCTTACGCTGGCAGGGGCAG
GACTGGACGCTCTTGCGTCCGCCCTGGTTACTGAAGAGCGGGATGGTGTTGCGTTTACGCGCAGAGTCTGGACGTCATCA
GCATTTATGGCTGGCGGCGGATAGCATGGAAGAAGCGGAATGGCGTGAGTTGCGTCGGATACTGTTACAGCAGCCGATAT
CAGGCCAACACTAA
Antitoxin
Download Length: 91 a.a. Molecular weight: 10428.11 Da Isoelectric Point: 10.0035
>AT153774 WP_253679674.1 NZ_CP051198:1307259-1307531 [Treponema sp. OMZ 787]
MNITEAKKNLTKEKIEELKALNDRPIDTSDIPELTKADFLEMYRPVKKPLSIRLDSDIIAWLKSYGKGYQSRINTILRQA
MNTDKKANVF
MNITEAKKNLTKEKIEELKALNDRPIDTSDIPELTKADFLEMYRPVKKPLSIRLDSDIIAWLKSYGKGYQSRINTILRQA
MNTDKKANVF
Download Length: 273 bp
>AT153774 NZ_CP067091:c3144718-3144452 [Salmonella enterica subsp. enterica serovar Typhimurium]
ATGGATATTCACAATAAAGCACGTATTCACTGGGCATGTCGTCGCGGTATGCGCGAACTTGATATTTCCATCATGCCGTT
TTTTGAACATGAGTACGATAGTTTAAGTGATGAAGAAAAGCGTATTTTTGTCCGTTTGTTGCAGAGTGATGACCCGGATT
TATTTAACTGGTTAATGAATCACGGTAAACCGGCTGACGCTGAACTGGAACAGATGGTCCGACTCATTCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA
ATGGATATTCACAATAAAGCACGTATTCACTGGGCATGTCGTCGCGGTATGCGCGAACTTGATATTTCCATCATGCCGTT
TTTTGAACATGAGTACGATAGTTTAAGTGATGAAGAAAAGCGTATTTTTGTCCGTTTGTTGCAGAGTGATGACCCGGATT
TATTTAACTGGTTAATGAATCACGGTAAACCGGCTGACGCTGAACTGGAACAGATGGTCCGACTCATTCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|
Antitoxin
| Source | ID | Structure |
|---|