153773

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 175089..175714 Replicon chromosome
Accession NZ_CP051198
Organism Treponema sp. OMZ 787

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag E4O05_RS00805 Protein ID WP_253722614.1
Coordinates 175319..175714 (+) Length 132 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag E4O05_RS00800 Protein ID WP_253677793.1
Coordinates 175089..175319 (+) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E4O05_RS00780 (E4O05_00770) 170306..170881 + 576 WP_253722610.1 SAP domain-containing protein -
E4O05_RS00785 (E4O05_00775) 170908..171840 + 933 WP_253722611.1 DUF4299 domain-containing protein -
E4O05_RS00790 (E4O05_00780) 171848..173899 - 2052 WP_253722612.1 elongation factor G -
E4O05_RS00795 (E4O05_00785) 173981..174880 - 900 WP_253722613.1 hypothetical protein -
E4O05_RS00800 (E4O05_00790) 175089..175319 + 231 WP_253677793.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
E4O05_RS00805 (E4O05_00795) 175319..175714 + 396 WP_253722614.1 type II toxin-antitoxin system VapC family toxin Toxin
E4O05_RS00810 (E4O05_00800) 175839..176726 + 888 WP_253677791.1 fructose bisphosphate aldolase -
E4O05_RS00815 (E4O05_00805) 176824..177585 - 762 WP_253722615.1 site-specific DNA-methyltransferase -
E4O05_RS00820 (E4O05_00810) 177592..178413 - 822 WP_253722616.1 TdeIII family type II restriction endonuclease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-123)

Antitoxin

SpoVT-AbrB domain

(7-51)


Sequences

Toxin        


Download         Length: 132 a.a.        Molecular weight: 15077.71 Da        Isoelectric Point: 9.9342

>T153773 WP_253722614.1 NZ_CP051198:175319-175714 [Treponema sp. OMZ 787]
MYLLDTNICIFLKNKKSPNVLQKIKENKHLGIYISSITVAELQFGVYNSKYVEKNKISLIKFLTPFSILNFDDRDAQEFG
KIRTSLKTEGKIIGAYDMLIAAQAIAKNLILVTNNTKEFCRIKNLNLEDWK

Download         Length: 396 bp

>T153773 NZ_CP067091:c3133604-3133206 [Salmonella enterica subsp. enterica serovar Typhimurium]
ATGCTGAAATTCATGCTTGATACCAATACCTGTATTTTCACCATCAAAAATAAGCCCGAACACATCAGAGAACGCTTCAA
CCTCAATACATCCCGAATGTGTATCAGCTCCATCACCTTAATGGAGCTGATTTACGGTGCTGAAAAAAGCCTGGCGCCGG
AGCGTAATCTTGCCGTCGTGGAGGGATTTATCTCCCGCCTTGAGGTTTTGGATTACGATACACAGGCAGCGATACATACC
GGTCAAATCCGTGCCGAACTGGCCCGCAAGGGAACACCTGTCGGGCCTTATGACCAGATGATTGCTGGCCATGCCGGTAG
CCGCGGACTGGTCGTCGTCACAAACAATCTCCGCGAATTTGAACGCATTCCGGGTATCCGAATCGAAGACTGGTGCTAA

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8874.04 Da        Isoelectric Point: 5.1229

>AT153773 WP_253677793.1 NZ_CP051198:175089-175319 [Treponema sp. OMZ 787]
METAKLFRNGRSQAVRLPKEYNFSGTEVFIRRAGESVILFPKNKEWETFLEGLNGFTDDFMVEGRCQPDLQDRKDL

Download         Length: 231 bp

>AT153773 NZ_CP067091:c3133831-3133604 [Salmonella enterica subsp. enterica serovar Typhimurium]
ATGCACACAACACTTTTTTTTAGTAACCGGACCCAGGCAGTCAGATTGCCTAAATCGATATCCTTTCCGGAGGATGTGAA
ACATGTCGAAATCATTGCGGTTGGCAGAAGCAGAATCATTACTCCAGTCGGAGAATCCTGGGACAGCTGGTTCGATGGCG
AAGGCGCCAGTACTGATTTTATGAGTACCAGAGAACAACCCGCAGTACAGGAACGGGAAGGATTTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References