Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PumA-relB/upstrm_HI1419-dnstrm_HI1420
Location 1436904..1437436 Replicon chromosome
Accession NZ_CP051197
Organism Treponema vincentii strain OMZ 802

Toxin (Protein)


Gene name PumA Uniprot ID -
Locus tag E4N70_RS06605 Protein ID WP_253817626.1
Coordinates 1437218..1437436 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag E4N70_RS06600 Protein ID WP_253817625.1
Coordinates 1436904..1437221 (-) Length 106 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E4N70_RS06580 (E4N70_06550) 1432363..1433088 - 726 WP_006187508.1 glycogen-binding domain-containing protein -
E4N70_RS06585 (E4N70_06555) 1433338..1434414 - 1077 WP_253817624.1 tRNA-dihydrouridine synthase family protein -
E4N70_RS06590 (E4N70_06560) 1434481..1436133 - 1653 WP_253811525.1 nucleoside kinase -
E4N70_RS06600 (E4N70_06570) 1436904..1437221 - 318 WP_253817625.1 putative addiction module antidote protein Antitoxin
E4N70_RS06605 (E4N70_06575) 1437218..1437436 - 219 WP_253817626.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
E4N70_RS06610 (E4N70_06580) 1437595..1439136 - 1542 WP_253817627.1 MiaB/RimO family radical SAM methylthiotransferase -
E4N70_RS06615 (E4N70_06585) 1439129..1440247 - 1119 WP_253817628.1 helix-turn-helix domain-containing protein -
E4N70_RS06620 (E4N70_06590) 1440329..1441015 - 687 WP_006187500.1 outer membrane lipoprotein carrier protein LolA -
E4N70_RS06625 (E4N70_06595) 1441063..1441230 - 168 WP_253817629.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(2-64)

Antitoxin

Uncharacterized protein HI1420

(4-95)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8413.77 Da        Isoelectric Point: 10.0027

>T153770 WP_253817626.1 NZ_CP051197:c1437436-1437218 [Treponema vincentii]
MRLKRGNKGDYRTIDKDIYELRIHFGPGYRIYCTDRNNEIILLLIAGDKSTQSKDIKKAQQMIKLLEQGEAK

Download         Length: 219 bp

>T153770 NZ_CP067091:c1626765-1626481 [Salmonella enterica subsp. enterica serovar Typhimurium]
ATGACTTATAAGCTGGCATTTAACGAATCAGCACTAAAAGAGTGGAAAAAACTGGGTCATACCATACAGGAACAGTTTAA
AAAAAAGCTAAGGGAACGGCTTGAAAACCCTCGGGTTCCGGCTTCTCAATTACATGGAAGAAAGGATCAGTACAAAATTA
AGCTGCGTGGTGCAGGATACAGGCTGGTGTACAGCGTCGAAGATGAAATTATCACGGTAACTGTCATTGGTGTTGGAAAG
CGTGAAAATGATGCCGTCTACAAAATGACACGACACAGAAGCTAA

Antitoxin


Download         Length: 106 a.a.        Molecular weight: 11692.33 Da        Isoelectric Point: 5.1473

>AT153770 WP_253817625.1 NZ_CP051197:c1437221-1436904 [Treponema vincentii]
MKITDFDPADYLTTKEAMIEYLNEALKTSIEDNTPEHFMEALGDVTRAQGITNAAKSTDLNREHLYRSLSKKGNPTFSTI
IKLIKFLGLEINITEAQSAKTAIAL

Download         Length: 318 bp

>AT153770 NZ_CP067091:c1627003-1626755 [Salmonella enterica subsp. enterica serovar Typhimurium]
ATGGCATTTCAAATTTTAACGACTACTGCAGCAAGCATTACAGAACTGAAACGTGATCCAATGGGAACTTTCAATGCCGG
AGATGGCGCTCCAGTTGCCATTCTTAACCGCAATGAACCGGCTTTCTACTGTGTGCCTCCGGCACTTTATGCTCATCTTA
TGGATATTCTTGAGGATGAAGAACTCGGTCGTATTATCGATGAGCGTGCGAATGAACGCGTCATTGAGGTCAACATTGAT
GACTTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References