Detailed information of TA system TA153769

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/YafQ-DinJ
• Location: 1056011..1056561
• Replicon: chromosome
• Accession: NZ_CP051197
• Organism: Treponema vincentii strain OMZ 802

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: E4N70_RS04970
• Protein ID: WP_253818992.1
• Coordinates: 1056011..1056292 (-)
• Length: 94 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: C8PQ87
• Locus tag: E4N70_RS04975
• Protein ID: WP_006188742.1
• Coordinates: 1056289..1056561 (-)
• Length: 91 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
E4N70_RS04960 (E4N70_04940)	1051243..1054530	-	3288	WP_253818990.1	DEAD/DEAH box helicase family protein	-
E4N70_RS04965 (E4N70_04945)	1054889..1055935	-	1047	WP_253818991.1	LD-carboxypeptidase	-
E4N70_RS04970 (E4N70_04950)	1056011..1056292	-	282	WP_253818992.1	type II toxin-antitoxin system YafQ family toxin	Toxin
E4N70_RS04975 (E4N70_04955)	1056289..1056561	-	273	WP_006188742.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
E4N70_RS04980 (E4N70_04960)	1056709..1057173	-	465	WP_253818993.1	hypothetical protein	-
E4N70_RS04985 (E4N70_04965)	1057157..1057795	-	639	WP_253818994.1	HEAT repeat domain-containing protein	-
E4N70_RS04990 (E4N70_04970)	1057819..1058724	-	906	WP_253818995.1	DUF4349 domain-containing protein	-
E4N70_RS04995 (E4N70_04975)	1058934..1059857	-	924	WP_253818996.1	TPM domain-containing protein	-
E4N70_RS05000 (E4N70_04980)	1059851..1061053	-	1203	WP_016517736.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, YafQ-like toxin (3-92)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (5-68)

Sequences

Toxin

Protein

• Length: 94 a.a.
• Molecular weight: 11087.00 Da
• Isoelectric Point: 9.9647

>T153769 WP_253818992.1 NZ_CP051197:c1056292-1056011 [Treponema vincentii]
MKYEVKFTTQFKKDLKLAKKQNKNLDKLLEVINLLSNGKKLEVKYRDHDLSGSYKGTRECHIEPDWLLVYEIRNDVLVLM
LYRLGSHSELFKK

Nucleotide

• Length: 282 bp

>T153769 NZ_CP067091:c528252-528034 [Salmonella enterica subsp. enterica serovar Typhimurium]
ATGTCTGATAAACCATTAACTAAAACTGATTATTTGATGCGTTTACGGCGCTGTCAGACAATTGACACTCTGGAGCGCGT
CATTGAGAAAAATAAATATGAATTGTCCGACAATGAGCTGGCTGTATTTTACTCAGCTGCGGATCACCGTCTTGCAGAAT
TGACGATGAACAAACTCTACGACAAGATCCCCTCTTCAGTATGGAAATTCATTCGTTAA

Antitoxin

Protein

• Length: 91 a.a.
• Molecular weight: 10113.61 Da
• Isoelectric Point: 4.6017

>AT153769 WP_006188742.1 NZ_CP051197:c1056561-1056289 [Treponema vincentii]
MATTNLNIRTDKEMKEQAEAIFFELGLTMTTAINMFLRTTIRENGIPFALKLDIPNATTVSAIEEGRKIAYDDSVKGYSN
IDDLRKALEI

Nucleotide

• Length: 273 bp

>AT153769 NZ_CP067091:c528654-528280 [Salmonella enterica subsp. enterica serovar Typhimurium]
ATGGACGAATACTCACCCAAAAGACATGATATAGCACAGCTTAAATTTCTTTGCGAAACCCTGTATCATGACTGTCTTGC
AAACCTTGAAGAAAGCAACCATGGCTGGGTTAATGACCCGACCTCAGCAGTCAACCTGCAGCTCAATGAGCTGATAGAGC
ATATTGCAACTTTCGCGCTTAATTATAAAATTAAGTACAATGAAGACAATAAATTGATTGCGCAGATAGATGAATACCTG
GACGACACCTTTATGTTGTTCAGCAGCTATGGTATTAATACGCAGGATTTGCAAAAATGGCGTAAATCGGGCAACCGCCT
GTTCCGTTGTTTCGTCAACGCCACCAGGGCCAATCCTGTTAGTTTGTCTTGTTAA

Structures

Antitoxin

• AlphaFold DB: C8PQ87