Detailed information of TA system TA153767

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mazEF/PRK09907-MazE
• Location: 84058..84623
• Replicon: chromosome
• Accession: NZ_CP051197
• Organism: Treponema vincentii strain OMZ 802

Toxin (Protein)

• Gene name: mazF
• Uniprot ID: -
• Locus tag: E4N70_RS00430
• Protein ID: WP_253818412.1
• Coordinates: 84058..84396 (-)
• Length: 113 a.a.

Antitoxin (Protein)

• Gene name: mazE
• Uniprot ID: C8PTV1
• Locus tag: E4N70_RS00435
• Protein ID: WP_006190331.1
• Coordinates: 84390..84623 (-)
• Length: 78 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
E4N70_RS00415 (E4N70_00420)	79314..80594	-	1281	WP_253818407.1	integron integrase	-
E4N70_RS00420 (E4N70_00425)	80746..82359	-	1614	WP_253818408.1	Na+/H+ antiporter NhaC family protein	-
E4N70_RS00425 (E4N70_00430)	82528..83694	+	1167	WP_253818410.1	DNA polymerase IV	-
E4N70_RS00430 (E4N70_00440)	84058..84396	-	339	WP_253818412.1	endoribonuclease MazF	Toxin
E4N70_RS00435 (E4N70_00445)	84390..84623	-	234	WP_006190331.1	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	Antitoxin
E4N70_RS00440 (E4N70_00450)	84738..85211	-	474	WP_253818414.1	GNAT family N-acetyltransferase	-
E4N70_RS00445 (E4N70_00455)	85530..86153	+	624	WP_253818415.1	TetR/AcrR family transcriptional regulator	-
E4N70_RS00450 (E4N70_00460)	86177..86632	+	456	WP_253818416.1	hypothetical protein	-
E4N70_RS00455 (E4N70_00465)	86697..86876	+	180	WP_006188197.1	hypothetical protein	-
E4N70_RS00460 (E4N70_00470)	87092..87943	+	852	WP_253818417.1	IS3 family transposase	-
E4N70_RS00465 (E4N70_00475)	88091..88573	-	483	WP_253818418.1	hypothetical protein	-
E4N70_RS00470 (E4N70_00480)	88723..89268	-	546	WP_253818421.1	DUF1697 domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• mRNA interferase PemK-like (10-110)

Antitoxin

• SpoVT-AbrB domain (6-48)

Sequences

Toxin

Protein

• Length: 113 a.a.
• Molecular weight: 12621.63 Da
• Isoelectric Point: 6.8427

>T153767 WP_253818412.1 NZ_CP051197:c84396-84058 [Treponema vincentii]
MVMSGFIPEKGDLVWLEFNPQAGHEQQGHRPAICVSQKLYNKKTGLALFCPITSHVKGYPFEVILNAHSIKGCILSDQIK
NLDYVQRKCSFIEKASDDEINSVVDNIKLMIE

Nucleotide

• Length: 339 bp

>T153767 NZ_CP067090:1637421-1637756 [Streptococcus pyogenes MGAS10870]
TTGGACTATAAGAAATATCAGATTATCTATGCTCCTGATGTTTTAGAGAAGCTAAAAGAAATTCGTGATTATATTTCTCA
AAACTATTCCTCAACATCAGGTCAGCGTAAAATGGAGCAAATCATTAGCGACATAGAAAAACTCGAGGTTTTCCCAGAAG
TTGGTTTTGATGCCGATGAAAAATATGGTTCAAAAATCAGCCATTATCACAGCACTAAAGGTTACACCTTAAGTAAAGAT
TATATTGTCCTATACCATATCGAGGGGGAAGAAAATAGGGTCGTTATTGATTACTTGCTTCCTACTCAAAGCGACTATAT
AAAGTTATTCAAATAA

Antitoxin

Protein

• Length: 78 a.a.
• Molecular weight: 8767.18 Da
• Isoelectric Point: 8.6592

>AT153767 WP_006190331.1 NZ_CP051197:c84623-84390 [Treponema vincentii]
MQAVVQKWGNSLGLRIPSLWAKDNNIKNGSKIEIIAEKGKMIILPQKKSLEDFMNLVTDKNLHSEINTFEAVGKEEW

Nucleotide

• Length: 234 bp

>AT153767 NZ_CP067090:1637144-1637431 [Streptococcus pyogenes MGAS10870]
ATGACTACAGTAAAAAAAAACAGAACGGTTACCTTTCAAGCTAATAAAGAACTGGTAAGCGAAGCAATGACAGTATTAAA
CAAAAAAAATTTAACCTTATCATCTGCTTTAAGATTATTCCTACAAAATGTCGTTGTCACAAACGAGGTTGACTTATTGA
CGGAAGAGGAGTTAGAGAAAGAAAAACTTTTCAAGCAATTTCAAGCTGAAATCAACAAAAATATTGAGGACGTTCGTCAA
GGGAAGTTTTATACCTCTGAAGAAGTGAGGGCTGAACTTGGACTATAA

Structures

Antitoxin

• AlphaFold DB: C8PTV1