Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 2624998..2625573 Replicon chromosome
Accession NZ_CP051196
Organism Treponema sp. OMZ 906

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag E4N69_RS11880 Protein ID WP_162664517.1
Coordinates 2624998..2625186 (+) Length 63 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag E4N69_RS11885 Protein ID WP_162664518.1
Coordinates 2625190..2625573 (+) Length 128 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E4N69_RS11865 (E4N69_11880) 2621061..2622770 + 1710 WP_253823955.1 methyl-accepting chemotaxis protein -
E4N69_RS11870 (E4N69_11885) 2622847..2623071 - 225 WP_162664516.1 YdbC family protein -
E4N69_RS11875 (E4N69_11890) 2624508..2624804 + 297 WP_253823956.1 type II toxin-antitoxin system RelB/DinJ family antitoxin -
E4N69_RS11880 (E4N69_11895) 2624998..2625186 + 189 WP_162664517.1 type II toxin-antitoxin system HicA family toxin Toxin
E4N69_RS11885 (E4N69_11900) 2625190..2625573 + 384 WP_162664518.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
E4N69_RS11890 (E4N69_11905) 2626055..2628040 + 1986 WP_253823957.1 exodeoxyribonuclease V subunit gamma -
E4N69_RS11895 (E4N69_11910) 2628088..2628585 + 498 WP_162664523.1 hypothetical protein -
E4N69_RS11900 (E4N69_11915) 2628596..2629423 + 828 WP_253823958.1 purine-nucleoside phosphorylase -
E4N69_RS11905 (E4N69_11920) 2629512..2630444 + 933 WP_253823959.1 RluA family pseudouridine synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(3-60)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(4-103)


Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7192.35 Da        Isoelectric Point: 10.1294

>T153766 WP_162664517.1 NZ_CP051196:2624998-2625186 [Treponema sp. OMZ 906]
MTFKEIEKLIKKDGWYLQSTIGSHYHYVHDSKKGKVTIPFHGNKELSKYVVNSILKQAGLKE

Download         Length: 189 bp

>T153766 NZ_CP067089:551185-551580 [Breznakiella homolactica]
ATGTATTTATTGGATACCAATATCTGCATTTATATAATAAATAAACGTCCTCAGGTTGTTATAGAAAAGATTAAAACGCT
GGAACCGATAGATATAAAACTATCATCTGTTTCTGTATCGGAATTAGAGTATGGAGTTTCGAAAAGTAAGTTTCGTGAAA
AGAATAGGGAAGCATTAATACATTTTATATCGGGATTTGACATAATTCCTTTTAATGAAATTGATGCCGAGGTATATGGA
CTGATACGGGCTGATTTGGAAAACAGAGGGGAAATAATTGGCCCCTATGATATGCACATAGCTTCACAGGCAATTTCGAG
AAATTTAATATTAGTAACAAATAACACGAATGAGTTTCAAAGAATAAAGAATCTGAAGTTAGAAAACTGGGTGTGA

Antitoxin


Download         Length: 128 a.a.        Molecular weight: 14207.24 Da        Isoelectric Point: 4.4076

>AT153766 WP_162664518.1 NZ_CP051196:2625190-2625573 [Treponema sp. OMZ 906]
MYIYPAFFYKDNDGYSVVFKDLELATGGSTLQEALLMAEEALTGRVYLMLQDGETLPAATEIGNITKPQDADFVTLIKTD
KKYLIQDKSVRKNVTLPAWLAEAAENANLNFSQELQNALKQRLQIAL

Download         Length: 384 bp

>AT153766 NZ_CP067089:550954-551184 [Breznakiella homolactica]
ATGCAAAGTACTAAAGTATTTATTAGCGGTAATAGCCAGGCGATACGGCTTCCCAAAGAATATCAGGTTGATGAAAAAGA
ATTATATGTTCAGAAAATTGGCGGAACAATAATTCTGTTATCAAAAAAGAACCCCTGGGACGCGTTTGAAAAAAGCCTTG
ATGAGTTTTCCGATGATTTTTTATCATCCGGTAGGAAGCAACCTAAAAGGCAGAAACGGGAATCATTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References