Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 2586955..2587530 Replicon chromosome
Accession NZ_CP051195
Organism Treponema sp. OMZ 803 strain BF2M

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag ABH09_RS11810 Protein ID WP_162664517.1
Coordinates 2586955..2587143 (+) Length 63 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag ABH09_RS11815 Protein ID WP_162664518.1
Coordinates 2587147..2587530 (+) Length 128 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ABH09_RS11790 (ABH09_11795) 2583649..2585358 + 1710 WP_253714559.1 methyl-accepting chemotaxis protein -
ABH09_RS11795 (ABH09_11800) 2585435..2585659 - 225 WP_162664516.1 YdbC family protein -
ABH09_RS11800 (ABH09_11805) 2586326..2586556 + 231 WP_253714560.1 hypothetical protein -
ABH09_RS11805 (ABH09_11810) 2586651..2586827 - 177 WP_253714561.1 hypothetical protein -
ABH09_RS11810 (ABH09_11815) 2586955..2587143 + 189 WP_162664517.1 type II toxin-antitoxin system HicA family toxin Toxin
ABH09_RS11815 (ABH09_11820) 2587147..2587530 + 384 WP_162664518.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
ABH09_RS11820 (ABH09_11825) 2587549..2587923 - 375 WP_253714562.1 hypothetical protein -
ABH09_RS11825 (ABH09_11830) 2588050..2590035 + 1986 WP_253714563.1 exodeoxyribonuclease V subunit gamma -
ABH09_RS11830 (ABH09_11835) 2590083..2590580 + 498 WP_162664523.1 hypothetical protein -
ABH09_RS11835 (ABH09_11840) 2590591..2591418 + 828 WP_253714564.1 purine-nucleoside phosphorylase -
ABH09_RS11840 (ABH09_11845) 2591507..2592439 + 933 WP_253714565.1 RluA family pseudouridine synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(3-60)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(4-103)


Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7192.35 Da        Isoelectric Point: 10.1294

>T153761 WP_162664517.1 NZ_CP051195:2586955-2587143 [Treponema sp. OMZ 803]
MTFKEIEKLIKKDGWYLQSTIGSHYHYVHDSKKGKVTIPFHGNKELSKYVVNSILKQAGLKE

Download         Length: 189 bp

>T153761 NZ_CP067074:469756-470049 [Rhizobium sp. AB2/73]
GTGAAACTTACTTGGTCTGCGTTCGCGTTATCGGATCGCGACGCCATCTTCACATACATTGAGGCAGATAATCCTGCGGC
CGCCGTTCTGGTCGACGAACGGATAGTCGCAGCCTCACGTCGCTTGCTCGATTTTCCCGCCAGCGGCCGTGTTGGTAGAA
TTGCCGGTACACGCGAACTCGTCATCAACGGCACGCCCTACGTAGCTGTTTATGCCGTTACCGACACGACAGTTCGAATT
CTTCGTGTATTGCATGGCGCGCAGGAATGGCCAGAGTCTGTGCCGATAAGCTAA

Antitoxin


Download         Length: 128 a.a.        Molecular weight: 14207.24 Da        Isoelectric Point: 4.4076

>AT153761 WP_162664518.1 NZ_CP051195:2587147-2587530 [Treponema sp. OMZ 803]
MYIYPAFFYKDNDGYSVVFKDLELATGGSTLQEALLMAEEALTGRVYLMLQDGETLPAATEIGNITKPQDADFVTLIKTD
KKYLIQDKSVRKNVTLPAWLAEAAENANLNFSQELQNALKQRLQIAL

Download         Length: 384 bp

>AT153761 NZ_CP067074:469451-469759 [Rhizobium sp. AB2/73]
ATGGCCGCAAACGCACTTGTCCAAACACGTATTGATGCCGAGGTTCGGGATCGTGCCTCTGCCGTTCTTGAGAGCATGGG
CCTTACGGTATCCGATGCGGTCCGTATATTGCTTACACGGACTGCCAACGAAGGGGCGCTCCCCCTTGAGCTCCTTTCGG
GGAGTGAGGCTCATGACGTTTGGTTTCGCAACAAGGTGCTCGAAGCGCTAAACGATACTCGCCCGGACGTATCCGACGAC
GAGGTTGAGGCGCATTTTGCCGAACGTCGAGCGGCTGCCCGTCTTAAAGCTGGTGCGCTCAAATCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References