Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 2273559..2274190 Replicon chromosome
Accession NZ_CP051195
Organism Treponema sp. OMZ 803 strain BF2M

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag ABH09_RS10320 Protein ID WP_253714321.1
Coordinates 2273559..2273960 (-) Length 134 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag ABH09_RS10325 Protein ID WP_253714322.1
Coordinates 2273960..2274190 (-) Length 77 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ABH09_RS10305 (ABH09_10305) 2269391..2271157 - 1767 WP_253714318.1 ABC transporter ATP-binding protein -
ABH09_RS10310 (ABH09_10310) 2271154..2272932 - 1779 WP_253714319.1 ABC transporter ATP-binding protein -
ABH09_RS10315 (ABH09_10315) 2273040..2273486 - 447 WP_253714320.1 hypothetical protein -
ABH09_RS10320 (ABH09_10320) 2273559..2273960 - 402 WP_253714321.1 type II toxin-antitoxin system VapC family toxin Toxin
ABH09_RS10325 (ABH09_10325) 2273960..2274190 - 231 WP_253714322.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
ABH09_RS10330 (ABH09_10330) 2274333..2274947 - 615 WP_162664234.1 TetR/AcrR family transcriptional regulator -
ABH09_RS10335 (ABH09_10335) 2275123..2276490 - 1368 WP_162664235.1 HD domain-containing protein -
ABH09_RS10340 (ABH09_10340) 2276518..2277753 - 1236 WP_253672900.1 cation:dicarboxylase symporter family transporter -
ABH09_RS10345 (ABH09_10345) 2278011..2278595 - 585 WP_162664237.1 flavin reductase family protein -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(2-123)

Antitoxin

(7-43)


Sequences


Toxin        


Download         Length: 134 a.a.        Molecular weight: 15357.65 Da        Isoelectric Point: 4.7187

>T153760 WP_253714321.1 NZ_CP051195:c2273960-2273559 [Treponema sp. OMZ 803]
MYLLDTNICIFLIKNTFPVLTKRIFSTSGNDLFLSSISIAEMEYGASKSQNREKNRKALLDFCVDFNILDFTAEDTETYG
MIRAYLEKEGSVIGPYDMQIAAQAMTRNLIVITNNYDEFARIPWIKVEDWTKK

Download         Length: 402 bp

>T153760 NZ_CP067074:c356466-355984 [Rhizobium sp. AB2/73]
ATGCTTTCCGCTCCGGCGCTTCTTGAGGAGGCGCATGACCTTGACCTGTTCCAGAGCGGAAACGATACGCTCGATGAATG
GCTGCGCCGCCGCGCGCGACCCAATCAGGTCAGCGGTGCGTCCCGGACCTATGTCGTCGCCGAGGGGCAGCGCGTCGTCG
GCTATTATTGCCTTGCGTCTGGCGCGCTCGATCTGGCCGATGCGCCGGGATCGGTTCGGCGAAACATGCCAGATCCAATT
CCCATGGCGGTTCTTGGTCGGCTTGCCATCGATCGCGGTTGGCAGGGCAGGGGATTGGGCGCGGCGCTTTTGCAGGATGC
CGTCCTTCGCACATCGCAGGCGGCGTCCATCATGGGCATTCGCGGCCTTCTTGTGCATGCGATTTCCGAAGACGCCAAAG
CCTTTTACGAGCACTATGGTTTCCTATGCTCTCCCAATCAACCCATGACGCTGGTGCTCTCGCTTAAGATCAGGACCGGA
TAG

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8840.16 Da        Isoelectric Point: 6.9785

>AT153760 WP_253714322.1 NZ_CP051195:c2274190-2273960 [Treponema sp. OMZ 803]
MVCAKVFMSGNSQAVRIPKEFHIDDTELFIKKIGTTIILYPQNRPWENLKKSLSEFSDDFMAEGRKQPSLTERETF

Download         Length: 231 bp

>AT153760 NZ_CP067074:c356750-356466 [Rhizobium sp. AB2/73]
ATGGCCACAAAATCGTTGACGGACTCACATGCCAAGCCGGTCCACCTGCGTATCCGCGAGGACGTGCGCAAGGTGATCGA
TCGCGCCGCCAGCATTCGCGGCAAGAGCCGCACGGATTTCATGATCGATGCGGCTTACCGCGCTGCGGAAGACGCCTTGC
TCGACCAAACTCTTGTGCGGGTTGATGAGGACAGCTATCGCCACTTCCTCTCCGTCCTCGATCAGCCGCCGAATGGGGAA
GGTTTCGAGCGGTTGATGAACGCGCCCAAGCCTTGGCAGTCCTGA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure


Antitoxin

Source ID Structure

References