Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PRK09907-MazE
Location 556600..557165 Replicon chromosome
Accession NZ_CP051195
Organism Treponema sp. OMZ 803 strain BF2M

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag ABH09_RS02560 Protein ID WP_253715083.1
Coordinates 556600..556938 (-) Length 113 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag ABH09_RS02565 Protein ID WP_253715084.1
Coordinates 556932..557165 (-) Length 78 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ABH09_RS02520 (ABH09_02530) 552149..552352 - 204 WP_253715075.1 hypothetical protein -
ABH09_RS02525 (ABH09_02535) 552379..552597 + 219 WP_253715076.1 helix-turn-helix domain-containing protein -
ABH09_RS02530 (ABH09_02540) 552779..553792 - 1014 WP_253715077.1 SH3 domain-containing protein -
ABH09_RS02535 (ABH09_02545) 553893..554213 - 321 WP_253715078.1 type II toxin-antitoxin system RelE/ParE family toxin -
ABH09_RS02540 (ABH09_02550) 554213..554458 - 246 WP_253715079.1 type II toxin-antitoxin system prevent-host-death family antitoxin -
ABH09_RS02545 (ABH09_02555) 554932..555540 - 609 WP_253715080.1 hypothetical protein -
ABH09_RS02550 (ABH09_02560) 555686..556075 - 390 WP_253715081.1 toxin-antitoxin system HicB family antitoxin -
ABH09_RS02555 (ABH09_02565) 556077..556334 - 258 WP_253715082.1 type II toxin-antitoxin system HicA family toxin -
ABH09_RS02560 (ABH09_02570) 556600..556938 - 339 WP_253715083.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
ABH09_RS02565 (ABH09_02575) 556932..557165 - 234 WP_253715084.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
ABH09_RS02570 (ABH09_02580) 557491..557796 - 306 WP_253715085.1 helix-turn-helix transcriptional regulator -
ABH09_RS02575 (ABH09_02585) 557937..558347 - 411 WP_253715086.1 hypothetical protein -
ABH09_RS02580 (ABH09_02590) 558554..559663 - 1110 WP_253715087.1 DUF4145 domain-containing protein -
ABH09_RS02585 (ABH09_02595) 559773..560648 - 876 WP_253715088.1 hypothetical protein -
ABH09_RS02590 (ABH09_02600) 560909..561214 - 306 Protein_498 tyrosine-type recombinase/integrase -
ABH09_RS02595 (ABH09_02605) 561291..561872 - 582 WP_253715089.1 SAP domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 551524..561237 9713


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(10-110)

Antitoxin

SpoVT-AbrB domain

(6-47)


Sequences

Toxin        


Download         Length: 113 a.a.        Molecular weight: 12937.93 Da        Isoelectric Point: 7.1651

>T153756 WP_253715083.1 NZ_CP051195:c556938-556600 [Treponema sp. OMZ 803]
MVNSNYVPDRGDLVCLDFNPQVRHEQKGRRPAICIFQKRYNQKVGLALFCPITSHIKGYPFEIVLDNHSINGCILSDQVK
NLDYKKRSCDFIEKITEEEINAVVDNIKLLIE

Download         Length: 339 bp

>T153756 NZ_CP067071:c3991496-3991092 [Rhizobium sp. AB2/73]
GTGAAGTATCTGCTCGACAGCAATGCGATCATCGCACTGATGAAAGGGCACCCCGGCTTCGTCGGCAAGCTTCGCAGGCA
CAAACCGCAGGATTTTGCCATTCCGGCCATCGTCGCACACGAGCTGATTTATGGTGCCTATAAGGGGCAGCGCGTTTCCG
ACAATCTGGCACGTGTCGATGCCCTGCAATTCGAGACGCTGGATTTCGATAAGCAAGATGCCCGTGTAGCCGGCGAAATT
CGCGCAAGCCTTGCTTCCCTCGGCACACCGATCGGTGCCTATGACGTTTTGATCGCGGGGCAAGCGGTCGCCCGCGATCT
GATCCTGATAACGCACAATGTCAAAGAATTTGGACGCGTCCCCAAGCTGCGTTTCGAAGACTGGGAGTCCTTGCCGAGCG
GCTAA

Antitoxin


Download         Length: 78 a.a.        Molecular weight: 8611.94 Da        Isoelectric Point: 7.0094

>AT153756 WP_253715084.1 NZ_CP051195:c557165-556932 [Treponema sp. OMZ 803]
MQVVVQKWGNSLGFRIPSLWAKDNNVKNGSKIEVIAEKGKIIILPQKKTLDDMLAMVTSENVHSEISTGYPVGNEEW

Download         Length: 234 bp

>AT153756 NZ_CP067071:c3991735-3991493 [Rhizobium sp. AB2/73]
ATGGACACCGCAAAGATCTTCTGGTCCGGCCGCTCGCAGGCCGTACGCTTGCCGAAGGAATTCCGCCTCGATGGCGAGGA
AGTCCGCATACGCCGGCAGGGAAAGGCAATCATTCTGGAGCCGATCACCGAAGATTGGGACTGGCTGGAAGCGGTAACAG
GCCCGGTCGACGATGACTTTGTAGAAGCAGCGACCGAGCAACCGGCTGAGCAGCAACGCCCCGAGTTGGATATCTTCAAG
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References